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5-氨基咪唑-4-甲酰胺-1-β-D-呋喃核糖苷5-磷酸盐

5-氨基咪唑-4-甲酰胺-1-β-D-呋喃核糖苷5-磷酸盐

CAS号:3031-94-5
英文名:5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranosyl 5′-monophosphate
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化合物简介
5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR) is an intermediate in the generation of inosine monophosphate. AICAR is an analog of adenosine monophosphate (AMP) that is capable of stimulating AMP-dependent protein kinase (AMPK) activity. AICAR has been used clinically to treat and protect against cardiac ischemic injury. The drug was first used in the 1980s as a method to preserve blood flow to the heart during surgery. Currently, the drug has also been shown as a potential treatment for diabetes by increasing the metabolic activity of tissues by changing the physical composition of muscle.
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