化合物简介
5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR) is an intermediate in the generation of inosine monophosphate. AICAR is an analog of adenosine monophosphate (AMP) that is capable of stimulating AMP-dependent protein kinase (AMPK) activity. AICAR has been used clinically to treat and protect against cardiac ischemic injury. The drug was first used in the 1980s as a method to preserve blood flow to the heart during surgery. Currently, the drug has also been shown as a potential treatment for diabetes by increasing the metabolic activity of tissues by changing the physical composition of muscle.
基本信息
中文名称
5-氨基咪唑-4-甲酰胺-1-β-D-呋喃核糖苷5-磷酸盐
英文名称
5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranosyl 5′-monophosphate
中文别名
5-氨基咪唑-4-甲酰胺-1-Β-D-呋喃核糖苷5-一磷酸盐
英文别名
Acadesine 5‘-phosphate、5\'-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-β-D-RIBOFURANOSYL 5\'-MONOPHOSPHATE
CAS号
3031-94-5
分子式
C9H15N4O8P
分子量
338.211
精确质量
338.063
PSA
213.19
LOGP
-1.4258
编号系统
UNII
F0X88YW0YK
物化性质
外观与性状
白色粉末带有粉红色
密度
2.3g/cm3
沸点
845.3ºC at 760 mmHg
熔点
198-202ºC dec.
闪点
465ºC
折射率
1.831
储存条件
-20ºC