化合物简介
Licarbazepine is a voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects that is related to oxcarbazepine. It is an active metabolite of oxcarbazepine. In addition, an isomer of licarbazepine, eslicarbazepine ((S)-(+)-licarbazepine), is an active metabolite of eslicarbazepine acetate. Oxcarbazepine and eslicarbazepine acetate are inactive on their own, and behave instead as prodrugs to licarbazepine and eslicarbazepine, respectively, to produce their therapeutic effects.
基本信息
中文名称
10,11-二氢-10-羟基卡马西平
英文名称
licarbazepine
中文别名
利卡西平
英文别名
10,11-Dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide,Licarbazepine、Licarbazepine,10,11-Dihydro-10-hydroxy-5H-dibenz(Z)[b,f]azepin-5-carboxamide、10,11-Dihydro-10-hydroxy Carbamazepine、10,11-Dihydro-10-hydroxycarbamazepine
CAS号
29331-92-8
分子式
C15H14N2O2
分子量
254.284
精确质量
254.106
PSA
66.56
LOGP
3.2582
编号系统
UNII
XFX1A5KJ3V
物化性质
密度
1.336g/cm3
沸点
431.3ºC at 760mmHg
熔点
186-189ºC
闪点
214.6ºC
折射率
1.677
蒸汽压
3.33E-08mmHg at 25°C
安全信息
海关编码
2933990090
上游原料
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