化合物简介
Estramustine (INN, USAN, BAN) (brand names Emcyt, Estracit), in salt form as estramustine phosphate sodium (USAN) (or estramustine sodium phosphate (BAN)) or estramustine phosphate meglumine, is an alkylating antineoplastic agent (that is, a chemotherapeutic) that is used in the treatment of prostate cancer throughout the world. It is a derivative of estradiol, an estrogen, with a nitrogen mustard-carbamate ester moiety attached. The drug has been withdrawn from a number of markets, including Australia, Brazil, Ireland, and Norway.
基本信息
中文名称
雌莫司汀
英文名称
estramustine
中文别名
雌氮芥
英文别名
Estracyt、Estramustina、17beta-Estradiol 3-(bis(2-chloroethyl)carbamate)、Estradiol 3-(N,N-bis(2-chloroethyl)carbamate)、[(8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] N,N-bis(2-chloroethyl)carbamate、estradiol-3-bis(2-chloroethyl)carbamate、Estramustinum
CAS号
2998-57-4
分子式
C23H31Cl2NO3
分子量
440.403
精确质量
439.168
PSA
49.77
LOGP
5.182
编号系统
UNII
35LT29625A
物化性质
密度
1.253 g/cm3
沸点
565.8ºC at 760 mmHg
熔点
104 - 105ºC
闪点
296ºC
折射率
1.576
储存条件
Store in original container in a cool dark place.
蒸汽压
1.23E-13mmHg at 25°C
