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雌酚酮

雌酚酮

CAS号：53-16-7

英文名：estrone

分子式

C18H22O2

熔点

258-260°C(lit.)

密度

1.164 g/cm3

分子量

270.366

沸点

445.2ºC at 760 mmHg

溶解度

0.03 g/L

信号词

Danger

危险品标志

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化合物简介

Estrone (E1, and also oestrone) is an estrogenic hormone secreted by the ovary as well as adipose tissue with the chemical name of 3-hydroxyestra-1,3,5(10)-triene-17-one and the chemical formula C18H22O2. Estrone is an odorless, solid crystalline powder, white in color with a melting point of 254.5°C and a specific gravity of 1.23. Estrone is one of several natural estrogens, which also include estriol and estradiol. Estrone is the least abundant of the three hormones; estradiol is present almost always in the reproductive female body, and estriol is abundant primarily during pregnancy.

基本信息

中文名称

雌酚酮

英文名称

estrone

中文别名

雌(甾)酮、雌(三烯酚)酮、雌激素酮、3-羟基雌甾-1,3,5(10)-三烯-17-酮、α-卵泡激素、雌甾酮、雌酮

英文别名

Femidyn、Estron、1,3,5(10)-Estratrien-3-ol-17-one、Kolpon、Estrona、E 1、Estra-1,3,5(10)-trien-17-one, 3-hydroxy-、Estrone、3-Hydroxy-1,3,5(10)-estratrien-17-one、Folisan、Folipex、ESTROL、Estrin

CAS号

53-16-7

分子式

C18H22O2

分子量

270.366

精确质量

270.162

PSA

37.3

LOGP

3.8174

编号系统

UNII

2DI9HA706A

物化性质

外观与性状

白色结晶粉末

密度

1.164 g/cm3

沸点

445.2ºC at 760 mmHg

熔点

258-260°C(lit.)

闪点

189.7ºC

折射率

165 ° (C=1, Dioxane)

水溶解性

0.03 g/L

稳定性

Stable under normal temperatures and pressures.

储存条件

Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Flammables-area.

安全信息

RTECS号

KG8575000

安全说明

S53-S45

危险类别码

R45; R60; R61

WGK Germany

3

海关编码

2937290090

包装等级

I; II; III

危险品标志

T

危险性防范说明

P210; P260; P280; P301 + P310 + P330; P302 + P352 + P312; P370 + P378

信号词

Danger

危险性描述

H225; H301 + H311 + H331; H370

危险标志

GHS02, GHS06, GHS08

生产方法及用途

生产方法

1.在17β-羟甾类脱氢酶的作用下由17β-雌二醇制成。 2.

用途

雌酚酮原料药功能是合成医药炔雌醇的原料药。

合成路线

共找到92条合成路线 >

19-hydroxy-4β,5-epoxy-5β-androstane-3,17 dione

19-hydroxy-4β,5-epoxy-5β-androstane-3,17 dione

雌酚酮

2-羟基雌酚酮

2-羟基雌酚酮

2β,19-epoxyandrost-4-ene-3,17-dione

2β,19-epoxyandrost-4-ene-3,17-dione

2α,19-dihydroxyandrost-4-ene-3,17-dione

2α,19-dihydroxyandrost-4-ene-3,17-dione

海关数据

共找到1个国家海关数据 >

国家/地区名称	海关编码	更新时间	操作
中国	2937290090	2019-03	查看

上游原料

共找到129个上游原料 >

2,4-二溴雌酮

2,4-二溴雌酮

(6aS,7aS,8R,11S,11aS,11bR)-2-methoxy-6a-methyl-5,6,6a,7a,8,11,11a,11b,12,13-decahydro-7H-8,11-methanoindeno[1,2-a]phenanthren-7-one

(6aS,7aS,8R,11S,11aS,11bR)-2-methoxy-6a-methyl-5,6,6a,7a,8,11,11a,11b,12,13-decahydro-7H-8,11-methanoindeno[1,2-a]phenanthren-7-one

gambiriin A1

19-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-androst-4-ene-3,17-dione

19-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-androst-4-ene-3,17-dione

3β,10β-Dihydroxy-19-norandrost-5-en-17-one

3β,10β-Dihydroxy-19-norandrost-5-en-17-one

下游产品

共找到70个下游商品 >

3,17-二丙酸-17-BETA-雌二酯

3,17-二丙酸-17-BETA-雌二酯

2-甲氧基雌素酮

2-甲氧基雌素酮

2-甲氧基雌二醇

2-甲氧基雌二醇

2-羟基雌酚酮

2-羟基雌酚酮

16alpha-羟基雌酚酮

16alpha-羟基雌酚酮

16-去氢雌二醇二醋酸酯

16-去氢雌二醇二醋酸酯

上游原料

2,4-二溴雌酮睾酮 (6aS,7aS,8R,11S,11aS,11bR)-2-methoxy-6a-methyl-5,6,6a,7a,8,11,11a,11b,12,13-decahydro-7H-8,11-methanoindeno[1,2-a]phenanthren-7-one gambiriin A1 19-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-androst-4-ene-3,17-dione 3β,10β-Dihydroxy-19-norandrost-5-en-17-one 8(9),14(15)-bisdehydroestrone 19-hydroxy-4β,5-epoxy-5β-androstane-3,17 dione 17-oxo-1,3,5(10)-estratrien-3-yl 2-(trimethylsilyl)ethyl butanedioate 3β-Hydroxy-19-norandrosta-1(10),5-dien-17-one 3-methoxy-13-methyl-7,11,12,16-tetrahydro-6H-cyclopenta[a]phenanthren-17-one 丙醇 3-甲氧基雌酮 (6aS,7aR,8S,11R,11aR,11bS,11cS)-2-methoxy-6a-methyl-6,6a,7a,8,11,11a,11b,11c,12,13-decahydro-7H-8,11-methanoindeno[1,2-a]phenanthren-7-one 3-O-苄基雌酮 19-tert-butyldimethylsilyloxy-androsta-1,4-diene-3,17-dione 雄烯二酮 (1R,2R,4S,5R)-4-(benzyloxy)-2-vinylbicyclo[3.2.1]octan-6-one 3-methoxy-estra-1,3,5(10),15-tetraen-17-one 三氟乙酸酐 (1R,2R,4S,5R,6R)-4-(benzyloxy)-6-(methoxymethoxy)-2-vinylbicyclo[3.2.1]octane (R)-methyl 3-((1S,2S)-2-allyl-2-methyl-3-oxocyclopentyl)pent-4-enoate 苄胺 (1S,2R,4S,5R,7S)-7-allyl-4-hydroxy-7-methyl-2-vinylbicyclo[3.2.1]octan-6-one (1S,4R,5R,7R)-7-(methoxymethoxy)-4-vinylbicyclo[3.2.1]octan-2-one 乙酸雌酮 (2Ξ,3SR)-2-Methyl-3-vinylcyclopentan-1-on 雌三醇 3β-Acetoxy-10β-hydroxy-19-norandrost-5-ene-17-one 10-beta-羟基雄甾-4-烯-3,17-二酮 3β-acetoxy-19-norandrosta-1(10),5-dien-17-one 19-羟基-4-雄甾烯-3,17-二酮马烯雌酮 3beta-乙酰氧基-19-羟基雄甾-5-烯-17-酮 [(8R,9S,10S,13S,14S)-13-methyl-3,17-dioxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-10-yl]methyl acetate 宝丹酮乙二醇 (1R,2R,4S,5S,6R)-4-(benzyloxy)-2-vinylbicyclo[3.2.1]octan-6-ol 19-Aldoandrostenedione 2α-acetoxy-19-oxoandrost-4-ene-3,17-dione 3-O-benzyl-estradiol-16-carboxylic acid (13S,14R)-3-methoxy-13-methyl-6,7,12,13-tetrahydro-11H-cyclopenta[a]phenanthren-17(14H)-one (1R,4R,5S,6S)-6-allyl-6-methyl-4-vinylbicyclo[3.2.1]octane-2,7-dione (1R,2S,4R,5R,7R)-7-(methoxymethoxy)-4-vinylbicyclo[3.2.1]octan-2-ol 雌莫司汀 (1S,2R,4S,5R,7S)-7-allyl-4-(benzyloxy)-7-methyl-2-vinylbicyclo[3.2.1]octan-6-one 4-氧代-4-{[17-氧代雌甾-1,3,5(10)-三烯-3-基]氧基}丁酸

下游产品

3,17-二丙酸-17-BETA-雌二酯 2-甲氧基雌素酮 2-甲氧基雌二醇 2-羟基雌酚酮 16alpha-羟基雌酚酮 16-去氢雌二醇二醋酸酯 (8R,9S,13S,14S,17S)-17-(6-羟基己基氨基)-13-甲基-6,7,8,9,11,12,14,15,16,17-十氢环戊烯并[a]菲-3-醇䓛 17B-雌二醇-D2 3,15α-dihydroxy-1,3,5(10)-estratrien-17-one 4-羟雌甾酮 (7a)-3,7-二羟基-雌甾-1,3,5(10)-三烯-17-酮苯甲酸雌二醇 17beta-雌二醇 17-乙酸酯 (17E)-17-甲氧基亚胺-13-甲基-7,8,9,11,12,14,15,16-八氢-6H-环戊二烯并[a]菲-3-醇 3-甲氧基雌酮雌甾-1,3,5(10),6-四烯-3,17-二醇雌酚酮 2-amino-3-hydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one beta-雌二醇 17-丙酸酯 4-amino-3-hydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one 雌二醇雌酮3-硫酸钠 17-氧代雌甾-1,3,5(10)-三烯-3-基-beta-D-吡喃葡糖苷酸 17-Beta-雌二醇 3-甲醚炔雌醇 Estra-1,3,5(10)-trien-17-one, 3-methoxy-, oxime 卟吩 3-O-苄基15,16-去氢雌酮 17β-二氢马烯雌酮 6Alpha-羟基雌酚酮 16-Oxo-17beta-estradiol 甲雌二醇 4-甲氧基雌酚酮雌二醇雌三醇 16Alpha-(β-D-葡萄糖醛酸苷)钠盐 (8R,9S,13S,14S,16E)-3-hydroxy-16-(methoxymethylidene)-13-methyl-6,7,8,9,11,12,14,15-octahydrocyclopenta[a]phenanthren-17-one 13-methyl-17-sulfanyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-ol 雌酮-2,4,16,16-d4 (17beta)-雌甾-1,3,5(10),9(11)-四烯-3,17-二醇雌酚酮-D2 雌三醇