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鲁比前列素

鲁比前列素

CAS号：333963-40-9

英文名：(2R,4aR,5R,7aR)-2-(1,1-Difluoropentyl)-2-hydroxy-6-oxo-3,4,4a,5,7,7a-hexahydrocyclopenta[b]pyran-5-heptanoic acid

分子式

C20H32F2O5

熔点

密度

1.175g/cm3

分子量

390.462

沸点

532.3ºC at 760 mmHg

溶解度

信号词

危险品标志

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基本信息

中文名称

鲁比前列素

英文名称

(2R,4aR,5R,7aR)-2-(1,1-Difluoropentyl)-2-hydroxy-6-oxo-3,4,4a,5,7,7a-hexahydrocyclopenta[b]pyran-5-heptanoic acid

中文别名

(2R,4AR,5R,7AR)-2-(1,1-二氟戊基)-2-羟基-6-氧代-3,4,4A,5,7,7A-六氢环戊并[B]吡喃-5-庚酸、鲁比前列酮、卢比前列酮

英文别名

Prostan-1-oic acid,11,15-epoxy-16,16-difluoro-15-hydroxy-9-oxo-,(11alpha,15R)、Spi 0211、7-[(2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yI]heptanoic acid、(2R,4aR,5R,7aR)-2-(1,1-Difluoropentyl)-2-hydroxy-6-oxo-3,4,4a,5,7,7a-hexahydrocyclopenta[b]pyran-5-h、Unii-7662kg2R6k、(-)-7-[(2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl]heptanoic acid、[3H]-Lubiprostone

CAS号

333963-40-9

分子式

C20H32F2O5

分子量

390.462

精确质量

390.222

PSA

83.83

LOGP

4.3099

物化性质

密度

1.175g/cm3

沸点

532.3ºC at 760 mmHg

闪点

275.7ºC

合成路线

lubiprostone benzyl ester

lubiprostone benzyl ester

鲁比前列素

鲁比前列素

上游原料

共找到32个上游原料 >

4,4-difluorooct-5-en-1-yn-3-ol

4,4-difluorooct-5-en-1-yn-3-ol

((1E,5E)-3-(4-methoxy-benzyloxy)-4,4-difluoroocta-1,5-dienyl)tributylstannane

((1E,5E)-3-(4-methoxy-benzyloxy)-4,4-difluoroocta-1,5-dienyl)tributylstannane

(3aR,4R,5R,6aS)-4-(4,4-difluoro-3-oxooctyl)-5-(tetrahydro-2H-pyran-2-yloxy)hexahydro-2H-cyclopenta[b]furan-2-one

(3aR,4R,5R,6aS)-4-(4,4-difluoro-3-oxooctyl)-5-(tetrahydro-2H-pyran-2-yloxy)hexahydro-2H-cyclopenta[b]furan-2-one

(E)-((4,4-difluorooct-5-en-1-yn-3-yloxy)methyl)benzene

(E)-((4,4-difluorooct-5-en-1-yn-3-yloxy)methyl)benzene

(Z)-7-[(1R,2R,3R)-3-[(tert-butyldimethylsilyl)oxy]-2-[(1E,5E)-4,4-difluoro-3-[(4-methoxyphenyl)methoxy]octa-1,5-dien-1-yl]-5-oxocyclopentyl]hept-5-enoic acid prop-2-yl ester

(Z)-7-[(1R,2R,3R)-3-[(tert-butyldimethylsilyl)oxy]-2-[(1E,5E)-4,4-difluoro-3-[(4-methoxyphenyl)methoxy]octa-1,5-dien-1-yl]-5-oxocyclopentyl]hept-5-enoic acid prop-2-yl ester

lubiprostone benzyl ester

lubiprostone benzyl ester

上游原料

4,4-difluorooct-5-en-1-yn-3-ol ((1E,5E)-3-(4-methoxy-benzyloxy)-4,4-difluoroocta-1,5-dienyl)tributylstannane (3aR,4R,5R,6aS)-4-(4,4-difluoro-3-oxooctyl)-5-(tetrahydro-2H-pyran-2-yloxy)hexahydro-2H-cyclopenta[b]furan-2-one (E)-((4,4-difluorooct-5-en-1-yn-3-yloxy)methyl)benzene (Z)-7-[(1R,2R,3R)-3-[(tert-butyldimethylsilyl)oxy]-2-[(1E,5E)-4,4-difluoro-3-[(4-methoxyphenyl)methoxy]octa-1,5-dien-1-yl]-5-oxocyclopentyl]hept-5-enoic acid prop-2-yl ester lubiprostone benzyl ester (1Z)-4,4-difluoro-1-(tributylstannyl)octa-1,5-dien-3-ol ((1E,5E)-3-(benzyloxy)-4,4-difluoroocta-1,5-dienyl)tributylstannane [(3aR,4S,5R,6aS)-hexahydro-5-hydroxy-4(triisopropylsilyloxymethyl)-2H-cyclopenta[b]furan-2-one] 鲁比前列素 (3aR,4R,5R,6aS)-4-(4,4-difluoro-3-hydroxyoctyl)-5-(tetrahydro-2H-pyran-2-yloxy)hexahydro-2H-cyclopenta[b]furan-2-ol (Z)-7-((1R,2R,3R,5S)-2-(4,4-difluoro-3-hydroxyoctyl)-5-hydroxy-3-(tetrahydro-2H-pyran-2-yloxy)cyclopentyl)hept-5-enoic acid [3aR-(3aalpha,4alpha,5beta,6aalpha)]-六氢-4-(羟基甲基)-5-苄氧基-2H-环戊二烯并[b]呋喃-2-酮 [(3aR,4R,5R,6aS)-hexahydro-2-oxo-5-(phenylmethoxy)-2H-cyclopenta[b]furan-4-carboxaldehyde] 科里内酯 (3aR,4R,5R,6aS)-4-(4,4-difluoro-3-oxooctyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl benzoate [3aR(3aα,4α,5β,6aα)]-(-)-5-(苯甲酰氧基)六氢-2-氧代-2H-环戊并[b]呋喃-4-甲醛 ethyl 2,2-difluoro-3-(trifluoromethylsulfonyloxy)hexanoate 4,4-difluoro-1-(trimethylsilyl)oct-5-en-1-yn-3-one (Z)-isopropyl 7-((1R,2R,3R)-2-((1E,5E)-3-(benzyloxy)-4,4-difluoroocta-1,5-dienyl)-3-(tert-butyldimethyl-silyloxy)-5-oxocyclopentyl)hept-5-enoate 7-[(2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxo-octahydrocyclopenta[b]pyran-5-yl]heptanoic acid propan-2-yl ester 7-((1R,2R,3R)-3-(tert-butyldimethylsilyloxy)-2-(4,4-difluoro-3-oxooctyl)-5-oxocyclopentyl)heptanoic acid (-)-6beta-羟甲基-7alpha-羟基-顺式-2-氧杂双环[3.3.0]辛-3-酮 2,2-difluoro-3-hydroxyhexanoic acid ethyl ester 7-[(1R,2R,3R)-3-[(tert-butyldimethylsilyl)oxy]-2-(4,4-difluoro-3-oxooctyl)-5-oxocyclopentyl]heptanoic acid propan-2-yl ester (Z)-7-[(1R,2R,3R,5S)-2-((E)-4,4-difluoro-3-hydroxy-1-octenyl)-3-(phenylmethoxy)-5-hydroxycyclopentyl]-5-heptenoic acid (3aR,4R,5R,6aS)-4-((E)-4,4-difluoro-3-hydroxy-1-octenyl)-5-(phenylmethoxy)-hexahydro-2H-cyclopenta[b]furan-2-ol 16,16-difluoro-13,14-dihydro-15-carbonyl-PGE2 benzyl ester [(3aR,4S,5R,6aS)-hexahydro-4-(triisopropylsilyloxymethyl)-5-(phenylmethoxy)-2H-cyclopenta[b]furan-2-one] ethyl 2,2-difluorohex-3-enoate (5Z)-7-[(3R)-3-[[(叔丁基)二甲基硅烷基]氧基]-5-氧代-1-环戊烯-1-基]-5-庚烯酸异丙酯 (3aR,4R,5R,6aS)-4-(4,4-difluoro-3-hydroxyoctyl)-5-(tetrahydro-2H-pyran-2-yloxy)hexahydro-2H-cyclopenta[b]furan-2-one