百科

加兰他敏

加兰他敏

CAS号：357-70-0

英文名：galanthamine

分子式

C17H21NO3

熔点

119-121ºC

密度

1.28 g/cm3

分子量

287.354

沸点

439.3ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

Galantamine (Nivalin, Razadyne, Razadyne ER, Reminyl, Lycoremine) is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments, in particular those of vascular origin. It is an alkaloid that is obtained synthetically or from the bulbs and flowers of Galanthus caucasicus (Caucasian snowdrop, Voronov's snowdrop), Galanthus woronowii (Amaryllidaceae) and related genera like Narcissus (daffodil), Leucojum aestivum (snowflake), and Lycoris including Lycoris radiata (red spider lily).

基本信息

中文名称

加兰他敏

英文名称

galanthamine

中文别名

11-甲基-3-甲氧基-4a,5,9,10,11,12-六氢-6H-苯并呋喃[3a,3,2ef][2]苯并氮杂卓-6-醇、强肌

英文别名

Galantamine Hydrobromide、Galanthamine

CAS号

357-70-0

分子式

C17H21NO3

分子量

287.354

精确质量

287.152

PSA

41.93

LOGP

1.7882

编号系统

UNII

0D3Q044KCA

物化性质

外观与性状

灰白色固体

密度

1.28 g/cm3

沸点

439.3ºC at 760 mmHg

熔点

119-121ºC

闪点

219.5ºC

安全信息

海关编码

2942000000

生产方法及用途

用途

用于神经系统疾病及外伤所致运动障碍、多发神经炎、神经根炎等。

合成路线

共找到7条合成路线 >

加兰他敏

加兰他敏

上游原料

共找到69个上游原料 >

2-bromo-1-(tert-butyldimethylsilyloxymethyl)-3-[2-(tertbutyldimethylsiloxymethyl)cyclohex-2-enyl-1-oxy]-4-methoxy-benzene

2-bromo-1-(tert-butyldimethylsilyloxymethyl)-3-[2-(tertbutyldimethylsiloxymethyl)cyclohex-2-enyl-1-oxy]-4-methoxy-benzene

(-)-3-deoxygalanthamine

(-)-3-deoxygalanthamine

4-methoxy-3,5-bis(phenylmethoxy)benzaldehyde

4-methoxy-3,5-bis(phenylmethoxy)benzaldehyde

(3S,4R)-1-allyl-4-methyl-4'-methylene-1'-propyl-1',4'-dihydro-2'H-spiro[pyrrolidine-3,3'-quinoline]-2,2'-dione

(3S,4R)-1-allyl-4-methyl-4'-methylene-1'-propyl-1',4'-dihydro-2'H-spiro[pyrrolidine-3,3'-quinoline]-2,2'-dione

(4aS,6R,8aS)-4a,5,9,10,11,12-hexahydro-6-hydroxy-3-methoxy-11,11-dimethyl-6H-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium iodide

(4aS,6R,8aS)-4a,5,9,10,11,12-hexahydro-6-hydroxy-3-methoxy-11,11-dimethyl-6H-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium iodide

ethyl 2-((4aS,9bR)-6-methoxy-2,4,4a,9b-tetrahydro-1H-spiro[dibenzo[b,d]furan-3,2'-[1,3]dioxolane]-9b-yl)acetate

ethyl 2-((4aS,9bR)-6-methoxy-2,4,4a,9b-tetrahydro-1H-spiro[dibenzo[b,d]furan-3,2'-[1,3]dioxolane]-9b-yl)acetate

下游产品

共找到7个下游商品 >

加兰他敏

加兰他敏

(4aS,6R,8aS)-11-甲基-5,6,9,10,11,12-六氢-4aH-[1]苯并呋喃并[3a,3,2-ef][2]苯并氮杂卓-3,6-二醇

(4aS,6R,8aS)-11-甲基-5,6,9,10,11,12-六氢-4aH-[1]苯并呋喃并[3a,3,2-ef][2]苯并氮杂卓-3,6-二醇

galanthamine n-butylcarbamate

galanthamine n-butylcarbamate

N-去甲基加兰它敏氢溴酸盐

N-去甲基加兰它敏氢溴酸盐

(4aS,6R,8aS)-3-甲氧基-11-甲基-5,6,9,10,11,12-六氢-4ah-[1]苯并呋喃并[3a,3,2-ef][2]苯并氮杂卓-6-醇 11-氧化物

(4aS,6R,8aS)-3-甲氧基-11-甲基-5,6,9,10,11,12-六氢-4ah-[1]苯并呋喃并[3a,3,2-ef][2]苯并氮杂卓-6-醇 11-氧化物

上游原料

2-bromo-1-(tert-butyldimethylsilyloxymethyl)-3-[2-(tertbutyldimethylsiloxymethyl)cyclohex-2-enyl-1-oxy]-4-methoxy-benzene (-)-3-deoxygalanthamine 4-methoxy-3,5-bis(phenylmethoxy)benzaldehyde (3S,4R)-1-allyl-4-methyl-4'-methylene-1'-propyl-1',4'-dihydro-2'H-spiro[pyrrolidine-3,3'-quinoline]-2,2'-dione (4aS,6R,8aS)-4a,5,9,10,11,12-hexahydro-6-hydroxy-3-methoxy-11,11-dimethyl-6H-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium iodide ethyl 2-((4aS,9bR)-6-methoxy-2,4,4a,9b-tetrahydro-1H-spiro[dibenzo[b,d]furan-3,2'-[1,3]dioxolane]-9b-yl)acetate (4aR,6S,8aR)-4a,5,11,12-tetrahydro-6-hydroxy-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]-benzazepin-10(9H)-one Methyl 3,5-dihydroxy-4-methoxybenzoate O-methyl-L-eucotamine methyl 4-methoxy-3,5-bis(phenylmethoxy)benzoate N-去甲基加兰它敏氢溴酸盐 9,9b-di(hydroxymethyl)-6-methoxy-3,4,4a,9b-tetrahydrodibenzofuran (S)-(-)-methyl 6-(2-bromo-3-formyl-6-methoxyphenoxy)-cyclohex-1-enecarboxylate (4aS,8aS,13R,14aR)-13-benzyl-3-methoxy-6,12-dioxo-14-(2,2,2-trifluoroacetyl)-4a,5,9,10,12,13,14,14a-octahydro-6H-benzo[2,3]benzofuro[4,3-cd]imidazo[1,2-a]azepin-2-yl trifluoromethanesulfonate (Z)-9-N-(tert-butoxycarbonyl)-N-methylaminomethyl-6-methoxy-9b-(2-methoxyvinyl)-3,4,4a,9b-tetrahydrodibenzofuran (2R,11bR)-2-benzyl-8,10-bis(benzyloxy)-9-methoxy-1-(2,2,2-trifluoroacetyl)-1,5,6,11b-tetrahydrospiro[benzo[c]imidazo[1,2-a]azepine-7,1'-cyclohexane]-2',5'-diene-3,4'(2H)-dione 2-溴-3-羟基-4-甲氧基苯甲醛 (4aS,8aS,13R,14aR)-13-benzyl-3-methoxy-14-(2,2,2-trifluoroacetyl)-4a,5,9,10,14,14a-hexahydro-6H-benzo[2,3]benzofuro[4,3-cd]imidazo[1,2-a]azepine-6,12(13H)-dione (1R,4S,6R)-6-benzyloxy-4-[(tert-butyldimethylsilyl)oxy]-1-(2,3-dimethoxyphenyl)-2-cyclohexene-1-acetic acid ethyl ester methyl 6-(2,2,2-trichloroethoxycarbonyloxy)cyclohex-1-enoate 氢溴酸加兰他敏 (4R,6S)-4-benzyloxy-6-[(tert-butyldimethylsilyl)oxy]-3-(2,3-dimethoxyphenyl)-2-cyclohexen-1-one (4aS,6R,8aS)-1-bromo-3-methoxy-4a,5,9,10,11,12-hexahydro-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzaepine-6-ol [6-(2-bromo-3-dimethoxymethyl-6-methoxyphenoxy)cyclohex-1-enyl]methanol 加兰他敏 (1-formyl-4-methoxy-6,7-dihydro-5aH-dibenzofuran-9a-yl)acetonitrile (4aS,6R,8aS)-3-methoxy-5,6,9,10-tetrahydro-4aH-benzo[2,3]benzofuro[4,3-cd]azepin-6-ol ((5aS,9aS)-4-methoxy-1-((methylamino)methyl)-6,7-dihydrodibenzo[b,d]furan-9a(5aH)-yl)methanol (4aS,6R,8aS)-11-butyl-4a,5,9,10,11,12-hexahydro-3-methoxy-6H-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol (2S,5R)-5-benzyl-2-(3,5-dibenzyloxy-4-methoxyphenyl)-3-[2-(4-hydroxyphenyl)ethyl]imidazolidin-4-one 9-N-(tert-butoxycarbonyl)-N-methylaminomethyl-6-methoxy-3,4,4a,9b-tetrahydrodibenzofuran-9b-carbaldehyde (4aS,8aR)-3-methoxy-11-methyl-4a,5,11,12-tetrahydro-6H-benzo[2,3]benzofuro[4,3-cd]azepine-6,10(9H)-dione ethyl 2-(7-(2-iodo-6-methoxyphenoxy)-1,4-dioxaspiro[4.5]decan-8-ylidene)acetate 2-((4aS,9bR)-6-methoxy-2,4,4a,9b-tetrahydro-1H-spiro[dibenzo[b,d]furan-3,2'-[1,3]dioxolane]-9b-yl)-N-methylacetamide L-eucotamine 2-bromo-3-(2-hydroxymethyl-cyclohex-2-enyloxy)-4-methoxybenzylalcohol (-)-isogalanthamine 9b-hydroxymethyl-9-N-(tert-butoxycarbonyl)-N-methylaminomethyl-6-methoxy-3,4,4a,9b-tetrahydrodibenzofuran N-formyl-N-norgalanthamine (4aS,6R,8aS,13R,14aR)-13-benzyl-6-hydroxy-3-methoxy-14-(2,2,2-trifluoroacetyl)-4a,5,9,10,14,14a-hexahydro-6H-benzo[2,3]benzofuro[4,3-cd]imidazo[1,2-a]azepin-12(13H)-one 9a-hydroxymethyl-4-methoxy-5a,6,7,9a-tetrahydrodibenzofuran-1-carbaldehyde (4aS,8aS,13R,14aR)-13-benzyl-2-hydroxy-3-methoxy-14-(2,2,2-trifluoroacetyl)-4a,5,9,10,14,14a-hexahydro-6H-benzo[2,3]benzofuro[4,3-cd]imidazo[1,2-a]azepine-6,12(13H)-dione 1-hydroxy-2-phenylseleno-3-deoxylycoramine 没食子酸甲酯 (1S,4R,6S)-4-benzyloxy-6-[(tert-butyldimethylsilyl)oxy]-3-(2,3-dimethoxyphenyl)-2-cyclohexen-1-ol [6-(2-bromo-3-dimethoxymethyl-6-methoxyphenoxy)cyclohex-1-enyl]acetonitrile (3alpha)-3-脱氧-3-氯加兰它敏 3,5-bis(benzyloxy)-4-methoxybenzyl alcohol (S)-2-(6-(2-bromo-3-(dimethoxymethyl)-6-methoxyphenoxy)cyclohex-1-en-1-yl)acetonitrile

下游产品

加兰他敏加兰他敏 (4aS,6R,8aS)-11-甲基-5,6,9,10,11,12-六氢-4aH-[1]苯并呋喃并[3a,3,2-ef][2]苯并氮杂卓-3,6-二醇 galanthamine n-butylcarbamate N-去甲基加兰它敏氢溴酸盐 (4aS,6R,8aS)-3-甲氧基-11-甲基-5,6,9,10,11,12-六氢-4ah-[1]苯并呋喃并[3a,3,2-ef][2]苯并氮杂卓-6-醇 11-氧化物氢溴酸加兰他敏