化合物简介
Tenofovir alafenamide (INN/USAN, formerly GS-7340) is a nucleotide reverse transcriptase inhibitor and a prodrug of tenofovir. It was developed by Gilead Sciences for use in the treatment of HIV infection and chronic hepatitis B, and is applied in the form of tenofovir alafenamide fumarate (TAF). Closely related to the commonly used reverse-transcriptase inhibitor tenofovir disoproxil, TAF has greater antiviral activity and better distribution into lymphoid tissues than that agent.
基本信息
中文名称
替诺福韦艾拉酚胺
英文名称
Tenofovir alafenamide
中文别名
GS7340游离碱
英文别名
GS-7340、Sp-Tenofovir-phosphonamidate,phenyl,L-alanine isopropyl ester、TENOFOVIR ALAFENAMIDE、propan-2-yl (2S)-2-[[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-phenoxyphosphoryl]amino]propanoate、Tenofovir alafenamide free base
CAS号
379270-37-8
分子式
C21H29N6O5P
分子量
476.466
精确质量
476.194
PSA
153.29
LOGP
3.945
编号系统
UNII
EL9943AG5J
合成路线
