百科

阿西维辛

阿西维辛

CAS号：42228-92-2

英文名：Acivicin

分子式

C5H7ClN2O3

熔点

>200ºC (dec.)

密度

1.85g/cm3

分子量

178.574

沸点

341.6ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

Acivicin is an inhibitor of gamma-glutamyl transferase. It is fermented product of Streptomyces sviceus and has promise as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors.

基本信息

中文名称

阿西维辛

英文名称

Acivicin

中文别名

异恶唑醋酸

英文别名

ACIA、Antibiotic AT 125、Acivicinum、Acivicino、(2S)-2-amino-2-[(5S)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl]acetic acid、Acivicine、AT-125

CAS号

42228-92-2

分子式

C5H7ClN2O3

分子量

178.574

精确质量

178.015

PSA

84.91

LOGP

-0.1246

编号系统

UNII

O0X60K76I6

物化性质

密度

1.85g/cm3

沸点

341.6ºC at 760 mmHg

熔点

>200ºC (dec.)

闪点

160.4ºC

折射率

1.663

储存条件

2-8ºC

安全信息

安全说明

S36

危险类别码

R20/21/22

危险品运输编码

UN 3172

危险类别

6.1(b)

包装等级

III

危险品标志

Xn

合成路线

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2-(3-chloro-4,5-dihydro-1,2-oxazol-5-yl)-2-(1,3-dioxoisoindol-2-yl)acetic acid

2-(3-chloro-4,5-dihydro-1,2-oxazol-5-yl)-2-(1,3-dioxoisoindol-2-yl)acetic acid

仲丁醇

阿西维辛

上游原料

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threo-DL-N-benzyloxycarbonyl-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid o-nitrobenzyl ester

threo-DL-N-benzyloxycarbonyl-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid o-nitrobenzyl ester

N-benzyloxycarbonyl-2-aminotetrahydro-5-oxo-2-furancarboxylic acid

N-benzyloxycarbonyl-2-aminotetrahydro-5-oxo-2-furancarboxylic acid

N-benzyloxycarbonyl-α-(o-nitrobenzyl)-(Z)-α,β-dehydroglutamate

N-benzyloxycarbonyl-α-(o-nitrobenzyl)-(Z)-α,β-dehydroglutamate

erythro-DL-N-chloroacetyl-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid

erythro-DL-N-chloroacetyl-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid

erythro-DL-N-benzyloxycarbonyl-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid

erythro-DL-N-benzyloxycarbonyl-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid

L-Orn

下游产品

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阿西维辛

上游原料

threo-DL-N-benzyloxycarbonyl-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid o-nitrobenzyl ester N-benzyloxycarbonyl-2-aminotetrahydro-5-oxo-2-furancarboxylic acid N-benzyloxycarbonyl-α-(o-nitrobenzyl)-(Z)-α,β-dehydroglutamate erythro-DL-N-chloroacetyl-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid erythro-DL-N-benzyloxycarbonyl-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid L-Orn N-叔-丁氧羰基阿西维辛 diethyl 2-acetamido-2-(3-aminopropyl)malonate diethyl (γ-(N-(p-methoxybenzylidene)amino)propyl)acetamidomalonate N-oxide (S)-((S)-3-chloro-4,5-dihydro-isoxazol-5-yl)-phthalimido-acetic acid dicyclohexylamine (2R,3R)-2-(((benzyloxy)carbonyl)amino)-3-chloro-5-(hydroxyamino)-5-oxopentanoate (αS,5S)-α-[(methoxycarbonyl)amino]-4,5-dihydro-5-isoxazoleacetic acid methylidene ester 谷氨酸 L-threo-β-chloroglutamic acid (αS,5S)-α-[(methoxycarbonyl)amino]-5-isoxazolidineacetic acid methylidene ester alpha-酮戊二酸阿西维辛仲丁醇 benzyl ((3R,4R)-4-chloro-2,6-dioxotetrahydro-2H-pyran-3-yl)carbamate (αS,5S)-α-[(methoxycarbonyl)amino]-3-chloro-4,5-dihydro-5-isoxazoleacetic acid methylidene ester 2-(3-chloro-4,5-dihydro-1,2-oxazol-5-yl)-2-(1,3-dioxoisoindol-2-yl)acetic acid o-nitrobenzyl N-benzyloxycarbonyl-2-aminotetrahydro-5-oxo-2-furancarboxylate (2R,3R)-2-Benzyloxycarbonylamino-3-chloro-pentanedioic acid (S)-((S)-3-oxo-isoxazolidin-5-yl)-phthalimido-acetic acid 5-(carboxy-phthalimido-methyl)-3-oxo-isoxazolidine-2-carboxylic acid benzyl ester

下游产品