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苦鬼臼毒素

苦鬼臼毒素

CAS号：477-47-4

英文名：picropodophyllotoxin

分子式

C22H22O8

熔点

225-227ºC

密度

1.37g/cm3

分子量

414.405

沸点

597.9ºC at 760mmHg

溶解度

信号词

危险品标志

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化合物简介

Picropodophyllotoxin is an insulin-like growth factor 1 receptor (IGF-1R) inhibitor that selectively inhibits the growth of human hepatocellular cancer cells with no observed cytotoxicity on normal cells.

基本信息

中文名称

苦鬼臼毒素

英文名称

picropodophyllotoxin

中文别名

苦鬼臼素、IGF-1R抑制剂

英文别名

Furo[3‘,4‘:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, [5R-(5-,5a-,8a-,9-)]-、Furo[3\',4\':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one,5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, (5R,5aS,8aR,9R)-、Picropodophyllotoxin

CAS号

477-47-4

分子式

C22H22O8

分子量

414.405

精确质量

414.131

PSA

92.68

LOGP

2.4092

编号系统

UNII

0F35AOI227

物化性质

密度

1.37g/cm3

沸点

597.9ºC at 760mmHg

熔点

225-227ºC

闪点

210.2ºC

折射率

1.605

储存条件

2-8ºC

蒸汽压

3.82E-15mmHg at 25°C

安全信息

危险类别码

R36/37/38; R68; R25; R21

危险品运输编码

UN 3462 6.1/PG 2

危险品标志

Xi; T

合成路线

共找到4条合成路线 >

鬼臼毒素

苦鬼臼毒素

苦鬼臼毒素

上游原料

共找到38个上游原料 >

重氮甲烷

picropodophyllic acid hydrazide

picropodophyllic acid hydrazide

(-)-(1R,2S,3S)-1-(3,4,5-trimethoxyphenyl)-2-(methoxycarbonyl)-3-<<(tert-butyldimethylsilyl)oxy>methyl>-6,7-(methylenedioxy)-2,3-dihydro-4(1H)-naphtalenone

(-)-(1R,2S,3S)-1-(3,4,5-trimethoxyphenyl)-2-(methoxycarbonyl)-3-<<(tert-butyldimethylsilyl)oxy>methyl>-6,7-(methylenedioxy)-2,3-dihydro-4(1H)-naphtalenone

α-apopicropodophyllic acid

α-apopicropodophyllic acid

下游产品

共找到5个下游商品 >

1,3-benzodioxol-5-yl-(3,4,5-trimethoxyphenyl)methanone

1,3-benzodioxol-5-yl-(3,4,5-trimethoxyphenyl)methanone

6-(3,4,5-trimethoxybenzoyl)-1,3-benzodioxole-5-carboxylic acid

6-(3,4,5-trimethoxybenzoyl)-1,3-benzodioxole-5-carboxylic acid

7-(3,4,5-trimethoxyphenyl)-[1,3]dioxolo[4,5-f]isobenzofuran-5(7H)-one

7-(3,4,5-trimethoxyphenyl)-[1,3]dioxolo[4,5-f]isobenzofuran-5(7H)-one

依托泊甙

鬼臼毒素

上游原料

重氮甲烷 picropodophyllic acid hydrazide 水 (-)-(1R,2S,3S)-1-(3,4,5-trimethoxyphenyl)-2-(methoxycarbonyl)-3-<<(tert-butyldimethylsilyl)oxy>methyl>-6,7-(methylenedioxy)-2,3-dihydro-4(1H)-naphtalenone α-apopicropodophyllic acid 盐酸 4-(dimethoxy)methyl-5-formyl(1,2-methylenedioxy)benzene 2''-bromophenyl (3R,4R)-6,7-methylenedioxy-3-triisopropylsilyloxymethyl-4-(2'-trimethylsilylethoxy)methoxy-3,4-dihydronaphthalene-2-carboxylate (1S,2S,3R,4R)-2-acetoxymethyl-1,4-epoxy-6,7-methylenedioxy-3-triisopropylsilyloxymethyl-1,2,3,4-tetrahydronaphthalene (3R,4R)-6,7-methylenedioxy-2-(N-oxazolidinoyl)carbonyl-3-triisopropylsilyloxymethyl-4-(2'-trimethylsilylethoxy)methoxy-3,4-dihydronaphthalene (-)-3-(hydroxymethyl)picropodophyllone (1R,2S,3R,4R)-6,7-methylenedioxy-2-(N-oxazolidinoyl)carbonyl-3-triisopropylsilyloxymethyl-1-(3',4',5'-trimethoxy)phenyl-4-(2''-trimethylsilylethoxy)methoxy-1,2,3,4-tetrahydronaphthalene (-)-(1R,2S)-1-(3,4,5-trimethoxyphenyl)-2-(methoxycarbonyl)-3-(((tert-butyldimethylsilyl)oxy)methyl)-6,7-(methylenedioxy)-1,2-dihydronaphtalene (3R,4R)-2-formyl-4-hydroxy-6,7-methylenedioxy-3-triisopropylsilyloxymethyl-3,4-dihydronaphthalene 5,8,8a,9-四氢-9-羟基-5-(3,4,5-三甲氧基苯基)-(5R,5aR,8aR,9S)-呋喃并[3',4':6,7]萘并[2,3-d]-1,3-二氧杂环戊烯-6(5aH)-酮 (1S,2S,3R,4R)-1,4-epoxy-2-hydroxymethyl-6,7-methylenedioxy-3-triisopropylsilyloxymethyl-1,2,3,4-tetrahydronaphthalene dimethyl 1,4-dihydro-1,4-epoxy-6,7-methylenedioxy-2,3-naphthalene-dicarboxylate podophyllotoxin 醋酸 α-apopicropodophyllotoxin 乙醇 (3R,4R)-6,7-methylenedioxy-3-triisopropylsilyloxymethyl-4-(2'-trimethylsilylethoxy)methoxy-3,4-dihydronaphthalene-2-carboxylic acid (5R)-5,8,8ab,9-四氢-5b-(3,4,5-三甲氧基苯基)呋喃并[3',4':6,7]萘并[2,3-d]-1,3-二氧杂环戊烯-6(5abH),9-二酮 meso-(1R*,2R*,3S*,4S*)-2,3-bis(acetoxymethyl)-1,4-epoxy-6,7-methylenedioxy-1,2,3,4-tetrahydronaphthalene 5-bromo-6-(dimethoxymethyl)-1,3-benzodioxole 4’-去甲鬼臼毒素 4'-O-demethyl-PPP 鬼臼毒素 4-(dimethoxy)methyl-5-hydroxymethyl(1,2-methylenedioxy)benzene dimethyl meso-(1R*,2S*,3R*,4S*)-(endo)-1,4-epoxy-6,7-methylenedioxy-1,2,3,4-tetrahydro-2,3-naphthalenedicarboxylate 6-{[(4R)-4-ethenyl-2-oxooxolan-3-yl](3,4,5-trimethoxyphenyl)methyl}-2H-1,3-benzodioxol-5-yl trifluoromethanesulfonate 硫酸二甲酯 meso-(1R*,2R*,3S*,4S*)-2,3-bis(hydroxymethyl)-1,4-epoxy-6,7-methylenedioxy-1,2,3,4-tetrahydronaphthalene (5R)-5-(3,4,5-trimethoxyphenyl)-8,9-dihydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-6-one (1R,2R,3S,4S)-2-acetoxymethyl-1,4-epoxy-3-hydroxy-6,7-methylenedioxy-1,2,3,4-tetrahydronaphthalene

下游产品

1,3-benzodioxol-5-yl-(3,4,5-trimethoxyphenyl)methanone 6-(3,4,5-trimethoxybenzoyl)-1,3-benzodioxole-5-carboxylic acid 7-(3,4,5-trimethoxyphenyl)-[1,3]dioxolo[4,5-f]isobenzofuran-5(7H)-one 依托泊甙鬼臼毒素