鬼臼毒素

鬼臼毒素

CAS号：518-28-5

英文名：podophyllotoxin

分子式

C22H22O8

熔点

183-184°C(lit.)

密度

1.37g/cm3

分子量

414.405

沸点

597.9ºC at 760 mmHg

溶解度

信号词

Danger

危险品标志

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化合物简介

Podophyllotoxin (abbreviated as PPT), otherwise known as podofilox, is a non-alkaloid toxin lignan extracted from the roots and rhizomes of Podophyllum species. Under the trade names Condylox, a gel, and Wartec, a solution or cream, it is used on the skin as a topical treatment of external genital warts, caused by some types of the human papillomavirus (HPV), and other warts. PPT and its synthetic derivatives display a wide selection in medical applications such as purgative, vesicant, antirheumatic, antiviral, and antitumor agents. These derivatives include etoposide and teniposide. Their anticancer activity has been heavily under study and used in various chemotherapies, including lung cancer, lymphomas, and genital tumors.

基本信息

中文名称

鬼臼毒素

英文名称

podophyllotoxin

中文别名

鬼臼脂毒

英文别名

Furo[3‘,4‘:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, [5R-(5-,5aα,8a-,9-)]-、Podophyllotoxin、(5R,5aR,8aR,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one

CAS号

518-28-5

分子式

C22H22O8

分子量

414.405

精确质量

414.131

PSA

92.68

LOGP

2.4092

编号系统

MDL号

MFCD00075290

物化性质

外观与性状

淡黄色-米色粉末

密度

1.37g/cm3

沸点

597.9ºC at 760 mmHg

熔点

183-184°C(lit.)

闪点

210.2ºC

稳定性

Stable under normal temperatures and pressures.

储存条件

2-8ºC

安全信息

RTECS号

LV2500000

安全说明

S36/37/39-S45

危险类别码

R23/25

WGK Germany

3

危险品运输编码

UN 3462 6.1/PG 2

海关编码

2942000000

危险类别

6.1(a)

包装等级

II

危险品标志

T

危险性防范说明

P261; P280; P302 + P350; P305 + P351 + P338; P310

危险性描述

H301; H310; H315; H319; H335

危险标志

GHS06

信号词

Danger

生产方法及用途

生产方法

从小檗科植物中华山荷叶(Diphylleia sinensishi Li)的根茎中提取。

用途

主要用于尖锐湿疣,也可用于其他病毒疣。

合成路线

共找到20条合成路线 >

(5R)-5,8,8ab,9-四氢-5b-(3,4,5-三甲氧基苯基)呋喃并[3',4':6,7]萘并[2,3-d]-1,3-二氧杂环戊烯-6(5abH),9-二酮

(5R)-5,8,8ab,9-四氢-5b-(3,4,5-三甲氧基苯基)呋喃并[3',4':6,7]萘并[2,3-d]-1,3-二氧杂环戊烯-6(5abH),9-二酮

鬼臼毒素

海关数据

共找到8个国家海关数据 >

国家/地区名称	海关编码	更新时间	操作
中国	2932999099	2019-03	查看
美国	2932997000	2019-03	查看
印度	29329900	2019-03	查看
欧盟	29329900	2019-03	查看
英国	2932990090	2019-03	查看
日本	293299000	2019-03	查看
韩国	2932999000	2019-03	查看
加拿大	2932990000	2019-03	查看

上游原料

共找到53个上游原料 >

5,6-dihydrocyclobuta[4,5]benzo[1,2-d][1,3]dioxol-5-ol

5,6-dihydrocyclobuta[4,5]benzo[1,2-d][1,3]dioxol-5-ol

鬼臼毒素-4-O-葡萄糖苷

鬼臼毒素-4-O-葡萄糖苷

4-(dimethoxy)methyl-5-formyl(1,2-methylenedioxy)benzene

4-(dimethoxy)methyl-5-formyl(1,2-methylenedioxy)benzene

3,4-二甲氧基苯乙酮

3,4-二甲氧基苯乙酮

2''-bromophenyl (3R,4R)-6,7-methylenedioxy-3-triisopropylsilyloxymethyl-4-(2'-trimethylsilylethoxy)methoxy-3,4-dihydronaphthalene-2-carboxylate

2''-bromophenyl (3R,4R)-6,7-methylenedioxy-3-triisopropylsilyloxymethyl-4-(2'-trimethylsilylethoxy)methoxy-3,4-dihydronaphthalene-2-carboxylate

(1R,2S,3R,4R)-4-O-(2-trimethylsilylethoxy)methylpicropodophyllin

(1R,2S,3R,4R)-4-O-(2-trimethylsilylethoxy)methylpicropodophyllin

下游产品

共找到23个下游商品 >

鬼臼毒素-4-O-葡萄糖苷

鬼臼毒素-4-O-葡萄糖苷

苦鬼臼毒素

苦鬼臼毒素

4'-demethyl-β-apopicropodophyllotoxin

4'-demethyl-β-apopicropodophyllotoxin

6-(3,4,5-trimethoxybenzoyl)-1,3-benzodioxole-5-carboxylic acid

6-(3,4,5-trimethoxybenzoyl)-1,3-benzodioxole-5-carboxylic acid

4'-demethyl-1-O-ethyl-1-epipodophyllotoxin

4'-demethyl-1-O-ethyl-1-epipodophyllotoxin

picropodophyllotoxin ethyl ether

picropodophyllotoxin ethyl ether

上游原料

5,6-dihydrocyclobuta[4,5]benzo[1,2-d][1,3]dioxol-5-ol 鬼臼毒素-4-O-葡萄糖苷 4-(dimethoxy)methyl-5-formyl(1,2-methylenedioxy)benzene 3,4-二甲氧基苯乙酮 2''-bromophenyl (3R,4R)-6,7-methylenedioxy-3-triisopropylsilyloxymethyl-4-(2'-trimethylsilylethoxy)methoxy-3,4-dihydronaphthalene-2-carboxylate (1R,2S,3R,4R)-4-O-(2-trimethylsilylethoxy)methylpicropodophyllin 丙酮 (1S,2S,3R,4R)-2-acetoxymethyl-1,4-epoxy-6,7-methylenedioxy-3-triisopropylsilyloxymethyl-1,2,3,4-tetrahydronaphthalene (-)-3-(hydroxymethyl)picropodophyllone (3R,4R)-2-formyl-4-hydroxy-6,7-methylenedioxy-3-triisopropylsilyloxymethyl-3,4-dihydronaphthalene 5,8,8a,9-四氢-9-羟基-5-(3,4,5-三甲氧基苯基)-(5R,5aR,8aR,9S)-呋喃并[3',4':6,7]萘并[2,3-d]-1,3-二氧杂环戊烯-6(5aH)-酮环丁酮 (3R,4R)-6,7-methylenedioxy-3-triisopropylsilyloxymethyl-4-(2'-trimethylsilylethoxy)methoxy-3,4-dihydronaphthalene-2-carboxylic acid 苦鬼臼毒素 meso-(1R*,2R*,3S*,4S*)-2,3-bis(acetoxymethyl)-1,4-epoxy-6,7-methylenedioxy-1,2,3,4-tetrahydronaphthalene 5-bromo-6-(dimethoxymethyl)-1,3-benzodioxole 4’-去甲鬼臼毒素 2-[6-(3,4,5-trimethoxybenzoyl)-1,3-benzodioxol-5-yl]acetic acid (5R,5aR,8R,8aR,9R)-8-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)oxy)-5-(3,4,5-trimethoxyphenyl)-5,5a,8a,9-tetrahydro-5,9-(epoxymethano)furo[3',4':6,7]naphtho[2,3-d][1,3]dioxole-6,11(8H)-dione dimethyl meso-(1R*,2S*,3R*,4S*)-(endo)-1,4-epoxy-6,7-methylenedioxy-1,2,3,4-tetrahydro-2,3-naphthalenedicarboxylate (5R,5aS,6R,8aR,9R)-6-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-8-oxo-9-(3,4,5-trimethoxy-phenyl)-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxole-5-carboxylic acid 6-溴-3,4-亚甲基二氧苯甲醛 (-)-Methyl epipodophyllate (5R)-5-(3,4,5-trimethoxyphenyl)-8,9-dihydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-6-one 重氮甲烷 (-)-4-O-(tert-butyldimethylsilyl)podophyllotoxin 3,4,5-三甲氧基苯甲醛 (-)-(1R,2S,3S)-1-(3,4,5-trimethoxyphenyl)-2-(methoxycarbonyl)-3-<<(tert-butyldimethylsilyl)oxy>methyl>-6,7-(methylenedioxy)-2,3-dihydro-4(1H)-naphtalenone α-apopicropodophyllic acid 盐酸 (5R,6R,7R,8R)-methyl 8-hydroxy-7-(hydroxymethyl)-5-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetrahydronaphtho[2,3-d][1,3]dioxole-6-carboxylate (+)-4-O-(tert-butyldimethylsilyl)picropodophyllin (3R,4R)-6,7-methylenedioxy-2-(N-oxazolidinoyl)carbonyl-3-triisopropylsilyloxymethyl-4-(2'-trimethylsilylethoxy)methoxy-3,4-dihydronaphthalene (1R,2S,3R,4R)-6,7-methylenedioxy-2-(N-oxazolidinoyl)carbonyl-3-triisopropylsilyloxymethyl-1-(3',4',5'-trimethoxy)phenyl-4-(2''-trimethylsilylethoxy)methoxy-1,2,3,4-tetrahydronaphthalene (-)-(1R,2S)-1-(3,4,5-trimethoxyphenyl)-2-(methoxycarbonyl)-3-(((tert-butyldimethylsilyl)oxy)methyl)-6,7-(methylenedioxy)-1,2-dihydronaphtalene [(5R,5aR,8aR,9R)-8-oxo-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-5-yl] acetate (1S,2S,3R,4R)-1,4-epoxy-2-hydroxymethyl-6,7-methylenedioxy-3-triisopropylsilyloxymethyl-1,2,3,4-tetrahydronaphthalene dimethyl 1,4-dihydro-1,4-epoxy-6,7-methylenedioxy-2,3-naphthalene-dicarboxylate (5R)-5,8,8ab,9-四氢-5b-(3,4,5-三甲氧基苯基)呋喃并[3',4':6,7]萘并[2,3-d]-1,3-二氧杂环戊烯-6(5abH),9-二酮 (1R,2R,3R,4R)-4-O-(2'-trimethylsilylethoxy)methylpodophyllotoxin 6,7-methylenedioxy-1-(3',4',5'-trimethoxyphenyl)-2-benzopyran-3-one (5S,5aS,6R,8aR,9R)-6-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)oxy)-8-oxo-9-(3,4,5-trimethoxyphenyl)-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl acetate 4-(dimethoxy)methyl-5-hydroxymethyl(1,2-methylenedioxy)benzene (5R,5aR,6R)-6-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)oxy)-8-oxo-9-(3,4,5-trimethoxyphenyl)-5,5a,6,8-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxole-5-carboxylic acid meso-(1R*,2R*,3S*,4S*)-2,3-bis(hydroxymethyl)-1,4-epoxy-6,7-methylenedioxy-1,2,3,4-tetrahydronaphthalene 5-chloro-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one

下游产品

鬼臼毒素-4-O-葡萄糖苷苦鬼臼毒素 4'-demethyl-β-apopicropodophyllotoxin 6-(3,4,5-trimethoxybenzoyl)-1,3-benzodioxole-5-carboxylic acid 4'-demethyl-1-O-ethyl-1-epipodophyllotoxin picropodophyllotoxin ethyl ether (3aR,4R,9R,9aR)-4,6,7-trihydroxy-9-(4-hydroxy-3,5-dimethoxyphenyl)-3a,4,9,9a-tetrahydro-3H-benzo[f][2]benzofuran-1-one 4’-去甲鬼臼毒素 (3aR,4S,9R,9aR)-4,6,7-trihydroxy-9-(4-hydroxy-3,5-dimethoxyphenyl)-3a,4,9,9a-tetrahydro-3H-benzo[f][2]benzofuran-1-one 6,7-O,O-demethylenepodophyllotoxin epipicropodophyllotoxin ethyl ether 4 ’-去甲去氧鬼臼毒素 (5S,5aR,8aR,9R)-5-ethylsulfanyl-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one 5-chloro-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one 5,8,8a,9-四氢-9-羟基-5-(3,4,5-三甲氧基苯基)-(5R,5aR,8aR,9S)-呋喃并[3',4':6,7]萘并[2,3-d]-1,3-二氧杂环戊烯-6(5aH)-酮 3',4'-didemethylepipodophyllotoxin 3',4',5'-tridemethylepipodophyllotoxin (5R)-5-(3,4,5-trimethoxyphenyl)-8,9-dihydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-6-one podophyllotoxin 3,4,5-三甲氧基苯甲酸 (5S,5aS,8aR,9R)-5-[(4-氟苯基)氨基]-9-(4-羟基-3,5-二甲氧基-苯基)-5a,6,8a,9-四氢-5H-异苯并呋喃并[5,6-f][1,3]苯并二氧戊环-8-酮 4'-去甲氧基表鬼臼毒素 (3aS,4S,9R,9aR)-4-(4-fluoroanilino)-6,7-dihydroxy-9-(4-hydroxy-3,5-dimethoxyphenyl)-3a,4,9,9a-tetrahydro-3H-benzo[f][2]benzofuran-1-one