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西他列汀
CAS号:486460-32-6
英文名:sitagliptin
分子式:C16H15F6N5O
分子量:407.314
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上游原料
1219440-28-4
L-tartaric acid (2S)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
1380521-88-9
(R,R)-N-benzyl-N-(α-methylbenzyl)-1-(2',4',5'-trifluorophenyl)-4-oxo-4-{3''-(trifluoromethyl)-5'',6''-dihydro-1'',2'',4''-triazolo[4,3-α]pyrazin-7''(8''H)-yl}butan-2-amine
1380243-39-9
(R)-tert-butyl (4-(benzyloxy)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate
1380521-86-7
tert-butyl (R,R)-3-[N-benzyl-N-(α-methyl-p-methoxybenzyl)amino]-4-(2',4',5'-trifluorophenyl)butanoate
1169707-29-2
(2Z)-1-[5,6-二氢-3-(三氟甲基)-1,2,4-三唑并[4,3-a]吡嗪-7(8H)-基]-3-[[(1R)-1-苯乙基]氨基]-4-(2,4,5-三氟苯基)-2-丁烯-1-酮
1352613-29-6
(S)-ethyl 3-hydroxy-4-(2,4,5-trifluorophenyl)butanoate
1048703-14-5
(R)-tert-butyl (4-hydroxy-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate
881995-69-3
西他列汀-int A8
1380243-37-7
(R)-tert-butyl (4-(methoxymethoxy)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate
1253055-98-9
(R)-3-azido-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
1380243-35-5
1242069-63-1
(R)-benzyl (4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate
1283096-74-1
(S)-3-hydroxy-4-(2,4,5-trifluorophenyl)butanenitrile
1351564-29-8
(R)-3-nitro-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
1352613-30-9
(S)-3-hydroxy-1-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
1352613-36-5
(S)-3-hydroxy-N-methoxy-4-(2,4,5-trifluorophenyl)butanamide
1329036-54-5
(R)-3-azido-4-(2,4,5-trifluorophenyl)butanoyl chloride
1404380-72-8
(S)-benzyl (1-(methoxy(methyl)amino)-1,4-dioxo-4-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)butan-2-yl)carbamate
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上游原料
L-tartaric acid (2S)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
(R,R)-N-benzyl-N-(α-methylbenzyl)-1-(2',4',5'-trifluorophenyl)-4-oxo-4-{3''-(trifluoromethyl)-5'',6''-dihydro-1'',2'',4''-triazolo[4,3-α]pyrazin-7''(8''H)-yl}butan-2-amine
(2Z)-1-[5,6-二氢-3-(三氟甲基)-1,2,4-三唑并[4,3-a]吡嗪-7(8H)-基]-3-[[(1R)-1-苯乙基]氨基]-4-(2,4,5-三氟苯基)-2-丁烯-1-酮
(S)-ethyl 3-hydroxy-4-(2,4,5-trifluorophenyl)butanoate
(R)-3-azido-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
(R)-benzyl (4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate
(S)-3-hydroxy-4-(2,4,5-trifluorophenyl)butanenitrile
(R)-3-nitro-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
(S)-3-hydroxy-1-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
(S)-3-hydroxy-N-methoxy-4-(2,4,5-trifluorophenyl)butanamide
(2S,5R)-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(2',4',5'-trifluorobenzyl)-pyrazine
3-氨基-1-[5,6-二氢-3-(三氟甲基)-1,2,4-噻唑并[4,3-a]吡嗪-7(8H)-基]-4-(2,4,5-三氟苯基)-2-丁烯-1-酮
(R)-2-(4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)isoindoline-1,3-dione
BOC-D-2,4,5-三氟苯丙氨酸
(2S)-1-(2-azido-4-pentenyl)-2,4,5-trifluorobenzene
3(R)-3-[(benzyloxy)amino]-1-[3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
2-(R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]-7(8H)-pyrazinyl]-1-(2,4,5-trifluorophenyl)-2-butanamine dodecylthio carbamate
3-三氟甲基-1,2,4-三唑并[4,3-a]吡嗪
(2Z)-4-氧代-4-[3-(三氟甲基)-5,6-二氢-[1,2,4]三唑并[4,3-a]吡嗪-7(8H)-基]-1-(2,4,5-三氟苯基)丁-2-烯-2-胺
2,4,5-三氟苯乙酸
(2S)-2-(2,4,5-trifluorobenzyl)-oxirane
(R)-t-butyl 4-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-4-oxo-3-(2,4,5-trifluorobenzyl)butanoate
(R)-1-(2,4,5-trifluorophenyl)pent-4-en-2-yl methanesulfonate
3-氨基-4-(2,4,5-三氟苯基)丁酸甲酯
(R)-N-benzyl-1-(2',4',5'-trifluorophenyl)-4-oxo-4-{3''-(trifluoromethyl)-5'',6''-dihydro-1'',2'',4''-triazolo[4,3-α]pyrazin-7''(8''H)-yl}butan-2-amine
(R)-3-(methoxyamino)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
2,4,5-三氟溴苯
(S)-1-chloro-3-(2,4,5-trifluorophenyl)propan-2-ol
(R)-4-(t-butoxy)-4-oxo-2-(2,4,5-trifluorobenzyl)butanoic acid
(R)-4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl methanesulfonate
3-(2,4,5-三氟苯基)丙酸
7-(1-oxo-3((R)-amino)-4-(2,4,5-trifluorophenyl)butyl)-3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine di-p-tolyl-L-tartarate
(S)-benzyl (1,4-dioxo-4-(3-(trifluoromethyl)-5,6,7,8-tetra hydro-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate
西他列汀-A
L-tartaric acid (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
西他列汀(S)-异构体磷酸盐
3-氧代-4-(2,4,5-三氟苯基)丁酸甲酯
(R)-N-叔丁氧羰基-2,4,5-三氟苯胺甲酯
(R)-3-(((benzyloxy)carbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic acid
2,4,5-三氟苄基溴
(2R)-1-(2,4,5-trifluorophenyl)-4-pentene-2-ol
(3R)-3-azido-4-(2,4,5-trifluorophenyl)-butyric acid
N-叔丁氧羰基-西他列汀
(3R)-N-叔丁氧羰基-3-氨基-4-(2,4,5-三氟苯基)丁酸
3-(三氟甲基)-5,6,7,8-四氢-[1,2,4]三唑并[4,3-a]吡嗪
(S)-4-(methoxyamino)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-yl methane-sulfonate
(3R)-3-[[(1R)-1-phenylethyl]amino]-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
(3S)-2’,4’,5’-三氟-3-羟基苯丁酸
下游产品
(2Z)-4-氧代-4-[3-(三氟甲基)-5,6-二氢-[1,2,4]三唑并[4,3-a]吡嗪-7-(8H)-基]-1-(2,4,5-三氟苯基)丁-2-酮
磷酸西他列汀一水合物