(2Z)-4-氧代-4-[3-(三氟甲基)-5,6-二氢-[1,2,4]三唑并[4,3-a]吡嗪-7(8H)-基]-1-(2,4,5-三氟苯基)丁-2-烯-2-胺_CAS号:767340-03-4

化合物简介

Sitagliptin intermediate. A dipeptidyl peptidase-4 inhibitor and an anti-hypertensive agent for the treatment of diabetes and hypertension.

基本信息

中文名称

(2Z)-4-氧代-4-[3-(三氟甲基)-5,6-二氢-[1,2,4]三唑并[4,3-a]吡嗪-7(8H)-基]-1-(2,4,5-三氟苯基)丁-2-烯-2-胺

英文名称

(Z)-3-amino-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)but-2-en-1-one

中文别名

(2Z)-4-氧代-4-[3-(三氟甲基)-5,6-二氢-[1,2,4]三唑并[4,3-A]吡嗪-7(8H)-基]-1-(2,4,5-三氟苯基)-2-丁烯胺、(2Z)-2-氨基-4-氧-4-[3-(三氟甲基)-5,6-二氢[1,2,4]三唑[4,3-Α]吡嗪-7(8H)-基]-1-(2,4,5-三氟苯基)丁基-2-烯(2-4)、西他列汀烯胺杂质、7(8H)-基]-1-(245-三氟苯基)丁-2-烯-2-胺

英文别名

2-Buten-1-ol,4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]、2-Buten-1-ol,4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-,(Z)、(2Z)-4-{[tert-butyl(dimethyl)silyl]oxy}but-2-en-1-ol、(2Z)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-en-2-amine、(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine、(Z)-4-(tert-butyl-dimethyl-silanyloxy)-but-2-en-1-ol、(Z)-3-amino-1-(3-trifluoromethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-4-(2,4,5-trifluorophenyl)but-2-en-1-one、(Z)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]-pyrazyn-7(8H)-yl)-4-(2,4,5-trifluorophenyl)but-2-en-1-one、cis-4-(1,1,2,2-tetramethyl-1-silapropoxy)but-2-en-1-ol、(2Z)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine、(2Z)-4-(tert-butyldimethylsilanyloxy)but-2-en-1-ol、cis-4-(tert-butyldimethylsilanyloxy)-but-2-en-1-ol

CAS号

767340-03-4

分子式

C16H13F6N5O

分子量

405.298

精确质量

405.102

PSA

77.04

LOGP

2.7799