化合物简介
Lynestrenol (INN, USAN, BAN, JAN), also known as 17α-ethinyl-3-desoxy-19-nortestosterone or 17α-ethynyl-4-estren-17β-ol, is a steroidal progestin. It is a synthetic, orally active progestogen associated with numerous effects of the natural progesterone hormone. Lynestrenol has a strong progestational effect on the uterine endometrium (transforming proliferative endometrium into secretory one), inhibits secretion of gonadotropin, suppresses maturation of follicles in the ovaries and ovulation, reduces menstrual bleeding. This synthetic gestagen is associated with minimal estrogenic, androgenic and anabolic effects. Lynestrenol is used in treatment of hormonal disorders and diseases caused by insufficient secretion of the natural progesterone, except in case of risky pregnancies and prevention of miscarriage, since it is not efficient enough in this indication.
基本信息
中文名称
利奈孕醇
英文名称
Lynestrenol
中文别名
类兴盖斯托
英文别名
org485-50、exluten、ethinylestrenol、19-Nor-4-pregnen-20-yn-17β-ol、exluton、lynenol、orgametil、LYNDIOL、Exlutena、exlutona、lynoestrenol、exlution
CAS号
52-76-6
分子式
C20H28O
分子量
284.436
精确质量
284.214
PSA
20.23
LOGP
4.3135
编号系统
UNII
N2Z8ALG4U5
物化性质
密度
1.08 g/cm3
沸点
399.6ºC at 760 mmHg
熔点
158ºC
闪点
176.9ºC
折射率
1.567