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炔诺酮

炔诺酮

CAS号:68-22-4
英文名:norethisterone
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化合物简介
Norethisterone (INN, BAN), also known as norethindrone (USAN), as well as 19-nor-17α-ethynyltestosterone, but more commonly known under its trade name Utovlan®, is a steroidal progestin used in some combined oral contraceptive pills and progestogen-only pills, and also available as a standalone drug. It can be used to treat premenstrual syndrome, painful periods, abnormal heavy bleeding, irregular periods, menopausal syndrome (in combination with estrogen), or to postpone a period. It is also commonly used to help prevent uterine hemorrhage in complicated non-surgical or pre-surgical gynecologic cases and in treating non responsive cyclical mastalgia. Norethisterone was the first orally highly active progestin to be synthesized.
基本信息
编号系统
物化性质
安全信息
生产方法及用途
生产方法
1.可由醋酸妊娠烯醇酮合成
2.制法: 于装有蒸馏装置的反应瓶中,加入氢氧化钾15g,甲苯120mL,异丁醇200mL,通入氮气,加热共沸脱水,直至将水脱尽。加入100mL四氢呋喃,控制30℃左右通入乙炔气体,25℃保温反应6h(乙炔吸收体积200倍)。冷却至0℃,继续通乙炔100倍。加入4-雄甾烯-19-去甲基-3,17-二酮
(2)10g(0.037mol)溶于60mL四氢呋喃的溶液,于5℃以下反应12h,同时不断通入乙炔气体。反应结束后,以30%的硫酸中和至PH1~2,控制反温度不超过40℃。减压蒸出四氢呋喃至固体析出时,进行水蒸汽蒸馏,以除去甲苯。冷却至25℃以下,抽滤,滤饼用水洗涤至中性,干燥,得粗品炔诺酮
(1)。粗品用1.5倍95%的乙醇洗涤一次,1倍70%的乙醇洗涤一次,再用15倍的95%的乙醇重结晶,活性炭脱色。过滤,滤液回收乙醇,冷却、析晶,过滤、干燥,得精品炔诺酮
(1),mp201~208℃,收率93%。
用途
孕激素类药,用于月经不调、子宫功能性出血、子宫内膜异位症等
国家/地区名称
海关编码
更新时间
操作
中国29372900902019-03查看