百科

四氢小檗碱

CAS号：522-97-4

英文名：canadine

分子式

C20H21NO4

熔点

密度

1.33 g/cm3

分子量

339.385

沸点

476.1ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

Canadine is a protoberberine alkaloid which can act as a calcium channel blocker. It is also one of the many alkaloids found in Corydalis yanhusuo from the family of Papaveraceae.

基本信息

中文名称

四氢小檗碱

英文名称

canadine

中文别名

二氢小檗碱、坎那定、5,8,13,13A-四氢-9,10-二甲氧基-6H-苯并[G]苯并-1,3-二恶茂并[5,6-A]喹嗪

英文别名

THB、l-Xanthopuccine、DL-CANADINE、l-Canadine、l-Tetrahydroberberine、TETRAHYDROBERBERINE、Tetrahydroberberine,THB

CAS号

522-97-4

分子式

C20H21NO4

分子量

339.385

精确质量

339.147

PSA

40.16

LOGP

3.0259

编号系统

UNII

V2SSH085X8

物化性质

密度

1.33 g/cm3

沸点

476.1ºC at 760 mmHg

闪点

141.1ºC

储存条件

2-8ºC

安全信息

安全说明

S36

危险类别码

R22

危险品标志

合成路线

(1S)-1-[3,4-dimethoxy-2-(S)-p-tolylsulfinyl]benzyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline

上游原料

7,8-dimethoxy-1,4-dihydroisochromen-3-one

29074-38-2

Canadine

1356336-75-8

(1S)-1-[3,4-dimethoxy-2-(S)-p-tolylsulfinyl]benzyl-6,7-methylenedioxy-2-(S)-p-tolylsulfinyl-1,2,3,4-tetrahydroisoquinoline

1356336-79-2

2-(2-chloroethyl)-4,5-methylenedioxybenzaldehyde

下游产品

9,10-二甲氧基-7-甲基-5,8,13,13A-四氢-6H-[1,3]二氧杂环戊并[4,5-g]异喹啉并[3,2-A]异喹啉-7-鎓

上游原料

(-)-canadine HCl 3,4-亚甲二氧基苯乙醇 7,8-dimethoxy-1,4-dihydroisochromen-3-one Canadine (1S)-1-[3,4-dimethoxy-2-(S)-p-tolylsulfinyl]benzyl-6,7-methylenedioxy-2-(S)-p-tolylsulfinyl-1,2,3,4-tetrahydroisoquinoline 2-(2-chloroethyl)-4,5-methylenedioxybenzaldehyde 3,4-亚甲二氧-beta-硝基苯乙烯 4-羟基苯乙酸甲酯胡椒乙胺 N-[2-(3,4-methylenedioxyphenyl)ethyl](3,4-dimethoxy-2-hydroxymethyl)-phenylacetamide (3-bromo-4-methoxy-phenyl)-acetic acid methyl ester (8S,14S)-(-)-8-cyanocanadine 8-羟基-7-甲氧基异苯并二氢吡喃-3-酮 2-(3-溴-4-羟基苯基)乙酸甲酯 α-dimethylamino-3,4-dimethoxytoluene 胡椒醛 (S)-2,3-dimethoxy-6-((5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)methyl)benzyl acetate 甲醛盐酸小檗碱 3-羟基-4-甲氧基苯乙酸 (S)-(+)-(E)-N-[2-(2-chloroethyl)-4,5-methylenedioxybenzylidene]-4-methylbenzenesulfinamide (1S)-1-[3,4-dimethoxy-2-(S)-p-tolylsulfinyl]benzyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline (S)-1-(chloromethyl)-3,4-dimethoxy-2-(p-tolylsulfinyl)benzene (S)-1-[3,4-dimethoxy-2-(p-tolylsulfinyl)phenyl]-N,N-dimethylmethanamine (S)-(2,3-dimethoxy-6-((5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)methyl)phenyl)methanol (S)-1,2-dimethoxy-4-methyl-3-(p-tolylsulfinyl)benzene 6-(2-(2-(benzo[d][1,3]dioxol-5-yl)ethylamino)-2-oxoethyl)-2,3-dimethoxybenzyl acetate

下游产品

Alpha-别隐品碱 Berberine iodide Berberinol 二氢白屈菜红碱二氢小檗碱 9,10-二甲氧基-7-甲基-5,8,13,13A-四氢-6H-[1,3]二氧杂环戊并[4,5-g]异喹啉并[3,2-A]异喹啉-7-鎓