二氢小檗碱

CAS号：483-15-8

英文名：9,10-Dimethoxy-6,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline

分子式

C20H19NO4

熔点

223-224ºC (dec.)

密度

1.37g/cm3

分子量

337.369

沸点

557.8ºC at 760mmHg

溶解度

信号词

危险品标志

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化合物简介

Dihydroberberine is a derivative Berberine, an isoqinoline alkaloid shown to have a chemopreventive property against colon tumor formation by inhibiting the enzyme cyclooxygenase-2 (cox-2) which is abundantly expressed in colon cancer cells.

基本信息

中文名称

二氢小檗碱

英文名称

9,10-Dimethoxy-6,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline

中文别名

英文别名

Dihydroberbine

CAS号

483-15-8

分子式

C20H19NO4

分子量

337.369

精确质量

337.131

PSA

40.16

LOGP

3.2402

物化性质

密度

1.37g/cm3

沸点

557.8ºC at 760mmHg

熔点

223-224ºC (dec.)

闪点

170.7ºC

折射率

1.678

蒸汽压

1.77E-12mmHg at 25°C

安全信息

海关编码

2934999090

合成路线

上游原料

2-(2-methyl-1H-indol-3-yl)-4-oxo-N,1-bis(3,4,5-trimethoxyphenyl)azetidine-2-carboxamide

113557-35-0

2-bromo-N-(2,3-dimethoxybenzyl)-4,5-methylenedioxyphenethylamine

7,8-dimethoxy-2-(3,4-methylenedioxyphenethyl)-1,2,3,4-tetrahydroisoquinolin-3-one

下游产品

共找到7个下游商品 >

54260-72-9

2,3-methylenedioxy-10,11-dimethoxy-13-methylprotoberberine chloride

O-methylpseudopianic acid

62595-72-6

berberinephenolbetaine

21796-14-5

降氧化北美黄连次碱

上游原料

四氢小檗碱 2-(2-methyl-1H-indol-3-yl)-4-oxo-N,1-bis(3,4,5-trimethoxyphenyl)azetidine-2-carboxamide 2-bromo-N-(2,3-dimethoxybenzyl)-4,5-methylenedioxyphenethylamine 四氢呋喃 berberinium, picrate 7,8-dimethoxy-2-(3,4-methylenedioxyphenethyl)-1,2,3,4-tetrahydroisoquinolin-3-one Berberinol 2-(6-bromo-benzo[1,3]dioxol-5-yl)-ethylamine 乙醚 Berberine iodide 盐酸小檗碱 2-(2-bromo-4,5-methylenedioxyphenethyl)-7,8-dimethoxy-4-methylthio-1,2,3,4-tetrahydroisoquinolin-3-one 2,3-二甲氧基苯甲醛小檗碱

下游产品

2,3-methylenedioxy-10,11-dimethoxy-13-methylprotoberberine chloride 盐酸小檗碱 Berberinol O-methylpseudopianic acid berberinephenolbetaine 降氧化北美黄连次碱 3-[3,4-dihydro-1-oxo-6,7-(methylenedioxy)-2H-isoquinolin-2-yl]-4,5-dimethoxy-1(3H)-isobenzofuranone