百科

雷帕霉素

雷帕霉素

CAS号：53123-88-9

英文名：sirolimus

分子式

C51H79NO13

熔点

183-185°C

密度

1.182 g/cm3

分子量

914.172

沸点

973.017ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

A triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, Rapa’Nui. Used as an immunosuppressant; antirestenotic. Sirolimus (INN/USAN), also known as rapamycin, is an immunosuppressant drug used to prevent rejection in organ transplantation; it is especially useful in kidney transplants.

基本信息

中文名称

雷帕霉素

英文名称

sirolimus

中文别名

西罗莫司

英文别名

RPM、RAPA、RAPAMUNE、Rapamycin (Sirolimus)、Rapamycin/Sirolimus、Rapamycin、RAPAMYCIN 1GM、SIROLIMUS、Rapamycin(Sirolimus)、sila9268a、23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine,AY 22989,Sirolimus、RAPAMYCIN、Rapamycin from Streptomyces hygroscopicus

CAS号

53123-88-9

分子式

C51H79NO13

分子量

914.172

精确质量

913.555

PSA

195.43

LOGP

6.1185

编号系统

UNII

W36ZG6FT64

物化性质

外观与性状

黄色固体

密度

1.182 g/cm3

沸点

973.017ºC at 760 mmHg

熔点

183-185°C

闪点

542.261ºC

折射率

1.55

稳定性

Stable if stored as directed.

储存条件

-20ºC

安全信息

安全说明

S22-S24/25

危险类别码

R36/38

海关编码

2942000000

危险品标志

Xi

生产方法及用途

用途

一种新型高效的免疫抑制剂，临床上用于器官移植的抗排斥反应和自身免疫性疾病的治疗。

合成路线

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31-(trimethylsilylether)rapamycin

31-(trimethylsilylether)rapamycin

二甲基氯氧化磷

二甲基氯氧化磷

42-(二甲基亚膦酰)雷帕霉素

42-(二甲基亚膦酰)雷帕霉素

雷帕霉素

海关数据

共找到1个国家海关数据 >

国家/地区名称	海关编码	更新时间	操作
中国	2942000000	2019-03	查看

上游原料

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(3S,5R,6R)-3-((1S,2R,4S)-1-hydroxy-5-((4-methoxybenzyl)oxy)-2,4-dimethylpentyl)-5,6-dimethoxy-5,6-dimethyl-1,4-dioxan-2-one

(3S,5R,6R)-3-((1S,2R,4S)-1-hydroxy-5-((4-methoxybenzyl)oxy)-2,4-dimethylpentyl)-5,6-dimethoxy-5,6-dimethyl-1,4-dioxan-2-one

31-(trimethylsilylether)rapamycin

31-(trimethylsilylether)rapamycin

二甲基氯氧化磷

二甲基氯氧化磷

(S)-1-Boc-哌啶-2-羧酸

(S)-1-Boc-哌啶-2-羧酸

(2R,5R,6R,7R,8R,10S,E)-2-(1,3-dithian-2-yl)-6-methoxy-7,11-bis((4-methoxybenzyl)oxy)-4,8,10-trimethylundec-3-en-5-ol

(2R,5R,6R,7R,8R,10S,E)-2-(1,3-dithian-2-yl)-6-methoxy-7,11-bis((4-methoxybenzyl)oxy)-4,8,10-trimethylundec-3-en-5-ol

(2S,3R)-4-((1S,3R,4R)-4-((tert-butyldimethylsilyl)oxy)-3-methoxycyclohexyl)-1-(2-((2R,5R,6S,7R,8R,10S,E)-6-methoxy-7,11-bis((4-methoxybenzyl)oxy)-4,8,10-trimethyl-5-((triethylsilyl)oxy)undec-3-en-2-yl)-1,3-dithian-2-yl)-3-methylbutan-2-ol

(2S,3R)-4-((1S,3R,4R)-4-((tert-butyldimethylsilyl)oxy)-3-methoxycyclohexyl)-1-(2-((2R,5R,6S,7R,8R,10S,E)-6-methoxy-7,11-bis((4-methoxybenzyl)oxy)-4,8,10-trimethyl-5-((triethylsilyl)oxy)undec-3-en-2-yl)-1,3-dithian-2-yl)-3-methylbutan-2-ol

下游产品

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2-((Z)-3-((1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-2-methylprop-1-en-1-yl)-4,6-dimethylphenol

2-((Z)-3-((1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-2-methylprop-1-en-1-yl)-4,6-dimethylphenol

甲基磷酸乙酯

甲基磷酸乙酯

42-(二甲基亚膦酰)雷帕霉素

42-(二甲基亚膦酰)雷帕霉素

2-((2R)-3-((1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-1-methoxy-2-methylpropyl)-4,6-dimethylphenol

2-((2R)-3-((1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-1-methoxy-2-methylpropyl)-4,6-dimethylphenol

L-哌啶-2-甲酸

L-哌啶-2-甲酸

二甲基磷酸

二甲基磷酸

上游原料

(3S,5R,6R)-3-((1S,2R,4S)-1-hydroxy-5-((4-methoxybenzyl)oxy)-2,4-dimethylpentyl)-5,6-dimethoxy-5,6-dimethyl-1,4-dioxan-2-one 31-(trimethylsilylether)rapamycin 二甲基氯氧化磷 (S)-1-Boc-哌啶-2-羧酸 (2R,5R,6R,7R,8R,10S,E)-2-(1,3-dithian-2-yl)-6-methoxy-7,11-bis((4-methoxybenzyl)oxy)-4,8,10-trimethylundec-3-en-5-ol (2S,3R)-4-((1S,3R,4R)-4-((tert-butyldimethylsilyl)oxy)-3-methoxycyclohexyl)-1-(2-((2R,5R,6S,7R,8R,10S,E)-6-methoxy-7,11-bis((4-methoxybenzyl)oxy)-4,8,10-trimethyl-5-((triethylsilyl)oxy)undec-3-en-2-yl)-1,3-dithian-2-yl)-3-methylbutan-2-ol (2R,3S,6R,9R,10S,11R,12R,14S,E)-1-((1S,3R,4R)-4-((tert-butyldimethylsilyl)oxy)-3-methoxycyclohexyl)-3-hydroxy-10-methoxy-11,15-bis((4-methoxybenzyl)oxy)-2,6,8,12,14-pentamethyl-9-((triethylsilyl)oxy)pentadec-7-en-5-one (S)-4-((2S,5R,6S)-6-((tert-butyldimethylsilyl)oxy)-5-methyltetrahydro-2H-pyran-2-yl)-3-methoxybutan-2-one (S,E)-5-((2S,5R,6R)-6-hydroxy-5-methyltetrahydro-2H-pyran-2-yl)-4-methoxy-3-methylpent-2-enal (S,E)-4-methoxy-3-methyl-5-((2S,5R)-5-methyl-6-oxotetrahydro-2H-pyran-2-yl)pent-2-enal methyl (R,E)-2-bromo-4-(1,3-dithian-2-yl)pent-2-enoate (R,E)-2-(4-bromopent-3-en-2-yl)-1,3-dithiane (R,E)-2-(4,5-dibromopent-3-en-2-yl)-1,3-dithiane (2R,4S)-2,4-dimethylpentane-1,5-diol (3S,5R,6R)-3-((1S,2R,4S)-1,5-bis((4-methoxybenzyl)oxy)-2,4-dimethylpentyl)-5,6-dimethoxy-5,6-dimethyl-1,4-dioxan-2-one (2R,4S)-5-(4-methoxybenzyloxy)-2,4-dimethylpentanal 1-(tert-butyl) 2-((2R,3S,6R,9R,10R,12R,14S,E)-1-((1S,3R,4R)-4-((tert-butyldimethylsilyl)oxy)-3-methoxycyclohexyl)-10-methoxy-2,6,8,12,14-pentamethyl-5,11,15-trioxo-9-((triethylsilyl)oxy)pentadec-7-en-3-yl) (S)-piperidine-1,2-dicarboxylate (((2R,5R,6S,7R,8R,10S,E)-2-(1,3-dithian-2-yl)-6-methoxy-7,11-bis((4-methoxybenzyl)oxy)-4,8,10-trimethylundec-3-en-5-yl)oxy)triethylsilane (2R,5R,6R,7S,8R,10S,E)-2-(1,3-dithian-2-yl)-6-methoxy-7,11-bis((4-methoxybenzyl)oxy)-4,8,10-trimethylundec-3-en-5-ol (((2R,5R,6S,7S,8R,10S,E)-2-(1,3-dithian-2-yl)-6-methoxy-7,11-bis((4-methoxybenzyl)oxy)-4,8,10-trimethylundec-3-en-5-yl)oxy)triethylsilane (2R,3S,6R,9R,10S,11S,12R,14S,E)-1-((1S,3R,4R)-4-((tert-butyldimethylsilyl)oxy)-3-methoxycyclohexyl)-3-hydroxy-10-methoxy-11,15-bis((4-methoxybenzyl)oxy)-2,6,8,12,14-pentamethyl-9-((triethylsilyl)oxy)pentadec-7-en-5-one (((2S,3R,6S)-6-((S)-3-(benzyloxy)-2-methoxypropyl)-3-methyltetrahydro-2H-pyran-2-yl)oxy)(tert-butyl)dimethylsilane 1-(tert-butyl) 2-((2R,3S,6R,9R,10S,11S,12R,14S,E)-1-((1S,3R,4R)-4-((tert-butyldimethylsilyl)oxy)-3-methoxycyclohexyl)-11,15-dihydroxy-10-methoxy-2,6,8,12,14-pentamethyl-5-oxo-9-((triethylsilyl)oxy)pentadec-7-en-3-yl) (S)-piperidine-1,2-dicarboxylate (S,E)-5-((2S,5R,6S)-6-((tert-butyldimethylsilyl)oxy)-5-methyltetrahydro-2H-pyran-2-yl)-4-methoxy-3-methylpent-2-enal 1-(tert-butyl) 2-((2R,3S,6R,7E,9R,10R,12R,14S,15E)-1-((1S,3R,4R)-4-((tert-butyldimethylsilyl)oxy)-3-methoxycyclohexyl)-16-iodo-10-methoxy-2,6,8,12,14-pentamethyl-5,11-dioxo-9-((triethylsilyl)oxy)hexadeca-7,15-dien-3-yl) (S)-piperidine-1,2-dicarboxylate (2S,3R,4R,6S)-2-methoxy-3,7-bis((4-methoxybenzyl)oxy)-4,6-dimethylheptanal (R,E)-2-bromo-4-(1,3-dithian-2-yl)pent-2-en-1-ol (S)-3-((2S,5R,6S)-6-((tert-butyldimethylsilyl)oxy)-5-methyltetrahydro-2H-pyran-2-yl)-2-methoxypropanal

下游产品

2-((Z)-3-((1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-2-methylprop-1-en-1-yl)-4,6-dimethylphenol 甲基磷酸乙酯 42-(二甲基亚膦酰)雷帕霉素 2-((2R)-3-((1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-1-methoxy-2-methylpropyl)-4,6-dimethylphenol L-哌啶-2-甲酸二甲基磷酸 2-((1R,2R)-1-hydroxy-3-((1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-2-methylpropyl)-4,6-dimethylphenol (1R,2R,4S)-4-{(2R)-2-[(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-二羟基-19,30-二甲氧基-15,17,21,23,29,35-六甲基-2,3,10,14,20-五氧代-11,36-二氧杂-4-氮杂三环[30.3.1.04,9]三十六碳-16,24,26,28-四烯-12-基]丙基}-2-甲氧基环己基2,2,5-三甲基-1,3-二恶烷-5-羧酸酯西罗莫司脂化物 2,4-二甲基苯酚 1-((1R,3S,4S)-3-hydroxy-4-methoxycyclohexyl)propan-2-one