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二环己基碳二亚胺

二环己基碳二亚胺

CAS号:538-75-0
英文名:1,3-dicyclohexylcarbodiimide
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化合物简介
N,N'-Dicyclohexylcarbodiimide is a carbodiimide used to couple amino acids during peptide synthesis. N,N'-Dicyclohexylcarbodiimide is used as a dehydrating agent for the preparation of amides, ketones, nitriles as well as in the inversion and esterification of secondary alcohols.
基本信息
编号系统
物化性质
安全信息
生产方法及用途
生产方法
1、二环己基硫脲法工业上由环己胺与二硫化碳反应生成N,N'-二环己基硫脲,经脱硫化氢而得。
2、二环己胺尿素法也可由N,N'-二环己基脲与五氧化二磷在吡啶中反应而得。
4、制N,N’一二环已基脉 将240克(2.42摩尔)环已胺与60克(1 .00摩尔)尿素在480毫升异戊醇中回流反应20小时。冷后滤出晶体,乙醚洗涤,于燥,得N,N’一二环已基豚200克,产率89%。
5、制二环已基碳二亚胺 将200克(0.891摩尔)二环已基脉,300克(1 .574摩尔)一甲苯磺既氯在600毫升无水吡啶中于70℃搅拌反应l小时。将反应物倒入1.5公斤碎冰中,用乙醚萃取。乙醚液用水洗涤、干燥。蒸去乙醚,残余物经减压蒸锚。得二环已基碳二亚胺152克(82%)。
用途
用作生化试剂和有机合成脱水缩合剂。
国家/地区名称
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中国29213000902019-03查看
美国29213050002019-03查看
印度292130902019-03查看
欧盟292130992019-03查看
英国29213099902019-03查看
日本2921300002019-03查看
韩国29213090002019-03查看
加拿大29213000002019-03查看
下游产品
尿素 苯甲酰胺 boc-β-alanine anhydride p-hydroxyphenylacetic acid N-oxysuccinimide ester (S)-2-(4-(((2-amino-4-hydroxypteridin-6-yl)methyl)amino)benzamido)-5-((2,5-dioxopyrrolidin-1-yl)oxy)-5-oxopentanoic acid 3-(methanesulfonylsulfanyl)-propionic acid 2-butyl-4-chloro-1-[p-(o-1H-tetrazol-5-ylphenyl)-benzyl]imidazole-5-methyl ester (2S)-2-[(Nα-tert-butyloxycarbonyl-leucyl)-amino]-1-trans-cinnamoylamino-3-methylbutane 1,2-HOPO-Thiaz(Bn) 2-(1-(2-hydroxyethyl)-2,6-dioxopiperidin-3-yl)isoindolin-1,3-dione (S)-2-(tert-butoxycarbonylamino)-3-phenylpropanoate 3α,12α-dihydroxy-5β-cholan-24-oic acid 2,5-dioxopyrrolidin-1-yl ester 溴乙酸 N-羟基琥珀酰亚胺酯 folic acid anhydride N-cyclohexyl-3-phenyl-1,2,4-oxadiazol-5-amine 2-tert-butoxycarbonylamino-3-[4-(4-formylphenoxy)-phenyl]-propionic acid benzyl ester N-环己基乙酰胺 外消旋1-油酰基-3-棕榈酰甘油 N-苯基环己烷甲酰胺 1-苯基-2,3-萘二羧酸酐 3-bromo-N-(naphthalen-1-ylmethyl)-benzo[b]thiophene-2-carboxamide 3,5-二苯基-1,2,4-恶二唑 1,3-双棕榈酸甘油酯 3-马来酰亚胺基丙酸羟基琥珀酰亚胺酯 环己酮 环己基异氰酸酯 1,3-di(tert-butyloxycarbonylamino)-2-[(tetradecylthio)acetyloxy]-propane 2-butyl-4-chloro-1-[(2'-(1H-tetrazol-5-yl) (1,1'-biphenyl)-4-yl)methyl]-1H-imidazole-5-carboxylic acid 4-(3H-1,2-dithiole-3-thione-5-yl)-phenyl ester 1-(pyrrolidin-1-ylmethyl)-2-[(3-oxo-indan)-formyl]-1,2,3,4-tetrahydroisoquinoline 2-(1-(2-hydroxyethyl)-2,6-dioxopiperidin-3-yl)isoindolin-1,3-dione (S)-2-(tert-butoxycarbonylamino)-3-methylbutanoate (2S)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl 2-bromo-2-(4-chlorophenyl)acetate 2-butyl-4-chloro-1-[(2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl]-1H-imidazole-5-carboxylic acid 2-(methylsulfonylthio)ethyl ester dodecyl N,N'-dicyclohexylcarbamimidate 3-bromo-N-[4-(trifluoromethyl)benzyl]-benzo[b]thiophene-2-carboxamide (S)-methyl 2-(4-chlorobenzamido)-3-(4-hydroxyphenyl)propanoate 雷米普利苄酯 N,N-二环己脲 (2S)-2-[(Nα-benzyloxycarbonyl-arginyl-leucyl)-amino]-1-trans-cinnamoylamino-3-methylbutane trifluoroacetate 顺式-1,3-环己烷二甲酸酐 N,N'-di-tert-butylcarbonyl-N,N'-bis(2-hydroxyethyl)ethylenediamine dioleate N-(3-吲哚基乙酰基)-DL-天冬氨酸 1-cyclohexyl-5-cyclohexylamino-3-phenyl-1H-1,2,4-triazole N-环己基-2-苯并噁唑胺 (2S)-2-amino-5-[2-(2-hydroxyethylsulfanyl)ethoxy]-5-oxopentanoate benzamide oxime p-toluenesulfonate N-(phenylpropynoyl)-N,N'-dicyclohexylurea Benzyloxycarbonyl-D-Ala-Phe 2-(1-(2-hydroxyethyl)-2,6-dioxopiperidin-3-yl)isoindolin-1,3-dione N-tert-butoxycarbonyl-(S)-2-pyrrolidinecarboxylate [6R(1R,2S)]-2-t-butoxycarbonylamino-4-t-buoxycarbonyloxy-5,8-di-t-butoxycarbonyl-6-(1,2-bis-(+/-)α-lipoyloxypropyl)-5,6,7,8-tetrahydropterdin N,N'-二环己基-4-吗啉脒