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维生素 D3

维生素 D3

CAS号：67-97-0

英文名：Vitamin D3

分子式

C27H44O

熔点

83-86°C(lit.)

密度

0.96 g/cm3

分子量

384.638

沸点

496.4ºC at 760 mmHg

溶解度

信号词

Danger

危险品标志

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化合物简介

胆钙化醇（英语：Cholecalciferol，又称为维生素D3或胆钙化固醇）是维生素D的一种，胆固醇脱氢后生成的7-脱氢胆固醇经紫外线照射即可形成胆钙化醇，因此也就是说胆钙化醇的维生素D原是7-脱氢胆固醇。胆钙化醇在肝脏中经羟化酶系作用形成25-羟胆钙化醇，再在肾脏中被羟化为1,25-二羟胆钙化醇，这种物质的活性较胆钙化醇高50%，被证明是维生素D在体内的真正活性形式。且1,25-二羟胆钙化醇属于肾脏分泌的一种激素，因此实际上胆钙化醇也是一种激素原。

基本信息

中文名称

维生素 D3

英文名称

Vitamin D3

中文别名

9,10-开环胆甾-5,7,10(19)-三烯-3beta-醇、胆钙化醇、活化7-去氢胆固醇、维生素D3

英文别名

Oxarol、Ebivit、calciol、Vi-De3、MC 1275、Devaron、CALCIOL、rampage、vitamin D3 powder、9,10-Secocholesta-5,7,10(19)-trien-3-ol, (3β,5Z,7E)-、(5Z,7E)-(3S)-9,10-secocholesta-5,7,10(19)-trien-3-ol、FeraCol、Prezios、Deparal、colecalciferol、vitamin D3、cholecalciferol、[3H]-Vitamin D3、(1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(1R)-1,5-dimethylhexyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylenecyclohexanol

CAS号

67-97-0

分子式

C27H44O

分子量

384.638

精确质量

384.339

PSA

20.23

LOGP

7.619

编号系统

UNII

1C6V77QF41

物化性质

外观与性状

结晶

密度

0.96 g/cm3

沸点

496.4ºC at 760 mmHg

熔点

83-86°C(lit.)

闪点

214.2ºC

折射率

1.507 (15ºC)

稳定性

Stable under normal temperatures and pressures.

储存条件

2-8ºC

安全信息

RTECS号

VS2900000

安全说明

S28-S36/37-S45-S28A

WGK Germany

2

危险类别码

R24/25; R26; R48/25

危险品运输编码

UN 2811 6.1/PG 2

海关编码

2936240000

危险类别

6.1

包装等级

II

危险品标志

T+

危险标志

GHS06, GHS08

信号词

Danger

危险性防范说明

P260; P280; P284; P301 + P310; P310

危险性描述

H301 + H311; H330; H372

生产方法及用途

生产方法

1.将7-脱氢胆固醇溶于乙醇，用紫外光照射开环，反应液浓缩、冷冻、过滤，滤液通氮减压浓缩至干，得粗维生素D3液。再经精制而得维生素D3。
2.从植物油或酵母中提取人体不能吸收的7-脱氢胆固醇，溶于氯仿或环己烷，用紫外线照射转化成维生素D3
3.将7-脱氢胆固醇溶于乙醇，用紫外光照射开环，反应液浓缩、冷冻、过滤，滤液通氮减压浓缩至干，得粗维生素Ｄ３，再经精制即可。

用途

维生素D3的维生素类药，主要促进肠内钙磷的吸收和沉积，用于治疗佝偻病及骨质软化病。

合成路线

共找到6条合成路线 >

cyclovitamin D3

cyclovitamin D3

维生素 D3

维生素 D3

上游原料

共找到52个上游原料 >

(1R,3aR,7aR)-7a-methyl-4-((E)-2-((1S,5R)-2-methylenebicyclo[3.1.0]hexan-1-yl)vinyl)-1-((R)-6-methylheptan-2-yl)octahydro-1H-inden-4-ol

(1R,3aR,7aR)-7a-methyl-4-((E)-2-((1S,5R)-2-methylenebicyclo[3.1.0]hexan-1-yl)vinyl)-1-((R)-6-methylheptan-2-yl)octahydro-1H-inden-4-ol

(S,Z)-3-(2-chloroethylidene)-4-methylenecyclohexyl benzoate

(S,Z)-3-(2-chloroethylidene)-4-methylenecyclohexyl benzoate

tert-butyldimethyl(((S,Z)-3-(2-((1R,3aS,7aR,E)-7a-methyl-1-((R)-6-methylheptan-2-yl)octahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexyl)oxy)silane

tert-butyldimethyl(((S,Z)-3-(2-((1R,3aS,7aR,E)-7a-methyl-1-((R)-6-methylheptan-2-yl)octahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexyl)oxy)silane

(1R,3aR,7aR)-7a-methyl-4-(((1R,5R)-2-methylenebicyclo[3.1.0]hexan-1-yl)ethynyl)-1-((R)-6-methylheptan-2-yl)octahydro-1H-inden-4-ol

(1R,3aR,7aR)-7a-methyl-4-(((1R,5R)-2-methylenebicyclo[3.1.0]hexan-1-yl)ethynyl)-1-((R)-6-methylheptan-2-yl)octahydro-1H-inden-4-ol

7α-bromocholest-5-en-3β-ol benzoate

7α-bromocholest-5-en-3β-ol benzoate

2-methylidenebicyclo[3.1.0]hexane-1-carbaldehyde

2-methylidenebicyclo[3.1.0]hexane-1-carbaldehyde

下游产品

共找到6个下游商品 >

叔丁基过氧化氢

叔丁基过氧化氢

维他命D3棕榈酸酯

维他命D3棕榈酸酯

维生素 D3

叔丁基[3-[2-(二苯基膦酰)亚乙基]-4-亚甲基环己基氧基]二甲基硅烷

叔丁基[3-[2-(二苯基膦酰)亚乙基]-4-亚甲基环己基氧基]二甲基硅烷

骨化二醇

{[(3Z)-3-(2-Chloroethylidene)-4-methylenecyclohexyl]oxy}(dimethyl )(2-methyl-2-propanyl)silane

{[(3Z)-3-(2-Chloroethylidene)-4-methylenecyclohexyl]oxy}(dimethyl )(2-methyl-2-propanyl)silane

上游原料

(1R,3aR,7aR)-7a-methyl-4-((E)-2-((1S,5R)-2-methylenebicyclo[3.1.0]hexan-1-yl)vinyl)-1-((R)-6-methylheptan-2-yl)octahydro-1H-inden-4-ol (S,Z)-3-(2-chloroethylidene)-4-methylenecyclohexyl benzoate tert-butyldimethyl(((S,Z)-3-(2-((1R,3aS,7aR,E)-7a-methyl-1-((R)-6-methylheptan-2-yl)octahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexyl)oxy)silane (1R,3aR,7aR)-7a-methyl-4-(((1R,5R)-2-methylenebicyclo[3.1.0]hexan-1-yl)ethynyl)-1-((R)-6-methylheptan-2-yl)octahydro-1H-inden-4-ol 7α-bromocholest-5-en-3β-ol benzoate 2-methylidenebicyclo[3.1.0]hexane-1-carbaldehyde [(1Z),(5S)]-2-[5-hydroxy-2-methylcyclohexylidene]-ethanol cyclovitamin D3 (R)-trimethyl(3-(oxiran-2-yl)prop-1-yn-1-yl)silane (((1R,5R)-2-methylenebicyclo[3.1.0]hexan-1-yl)ethynyl)lithium (-)-2(S)-methyl-2-(3-(mesyloxy)propyl)-1(S)-((phenylsulfonyl)methyl)-3(R)-(1(R),5-dimethylhexyl)cyclopentane (1R,3aR,7aR)-4-(dibromomethyl)-7a-methyl-1-((R)-6-methylheptan-2-yl)octahydro-1H-inden-4-ol cyclovitamin D3 (8E)-8-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-methylene]-de-A,B-cholestane (3R,3aR,7R,7aR)-3a-methyl-3-((R)-6-methylheptan-2-yl)-7-(phenylsulfonyl)octahydro-1H-inden-5-yl methanesulfonate (S)-1-(trimethylsilyl)oct-7-en-1-yn-4-ol 7-去氢胆固醇 (-)-(1S,3aR,4R,7aS)-1-<(phenylsulfonyl)methyl>-4-(4-methylpentyl)-3a,4,5,6,7,7a-hexahydro-7a-methylindan-5-one Grundmann’s ketone (Z)-3-(2-(diphenylphosphoryl)ethylidene)-4-methylenecyclohexyl benzoate 维生素 D3 (-)-(1(S)-methyl-2(S)-((phenylsulfonyl)methyl)-5(R)-(1(R),5-dimethylhexyl)cyclopentyl)acetaldehyde ethylene acetal (-)-<1(S)-methyl-2(S)-((phenylsylfonyl)methyl)-5(R)-(1(R),5-dimethylhexyl)cyclopentyl>acetaldehyde (-)-2(S)-methyl-2-(3-hydroxypropyl)-1(S)-((phenylsulfonyl)methyl)-3(R)-(1(R),5-dimethylhexyl)cyclopentane 3Β,6Z-9,10-断胆甾基-5(10),6,8-三烯甘油酯-3 (+)-(1(S)-methyl-2(S)-((phenylsulfonyl)methyl)-5(R)-(1(S)-(hydroxymethyl)-5-methylhexyl)cyclopentyl)acetaldehyde ethylene acetal [(3aS4E)-1t-((R)-1,5-dimethyl-hexyl)-7a-methyl-(3ar,7at)-octahydro-inden-4-yliden]-acetaldehyde 甲基2-亚甲基双环[3.1.0]己烷-1-羧酸酯 (Z)-2-(5-((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)-1-((1R,3aR,7aR)-7a-methyl-1-((R)-6-methylheptan-2-yl)-4-(phenylsulfonyl)octahydro-1H-inden-4-yl)ethyl acetate (+)-<1R,2'R,5R,6R,9R>-1-methyl-9-(6-methylhept-2-yl)-5-(phenylsulfonyl)bicyclo<4.3.0>nonane (2-methylenebicyclo[3.1.0]hexan-1-yl)methyl (2S)-2-methoxy-2-phenylacetate (8E)-8-bromomethylene-de-A,B-cholestane 2(S)-methyl-3(R)-(1(R),-dimethylhexyl)-1(S)-((phenylsulfonyl)methyl)-2-(2,3-epoxypropyl)cyclopentane {(S)-3-[1-Bromo-meth-(Z)-ylidene]-4-methylene-cyclohexyloxy}-tert-butyl-dimethyl-silane 8-bromomethylenedes-AB-cholestane (2Z)-2-[(5S)-5-{[二甲基(2-甲基-2-丙基)硅烷基]氧基}-2-亚甲基环己基亚基]乙醇 (-)-(3aR,4R,7aR)-5,5-(ethylenedioxy)-1(E)-((phenylsulfonyl)methylene)-4-(4-methylpentyl)-3a,4,5,6,7,7a-hexahydro-7a-methylindan (Z)-(2-(5-(1-ethoxyethoxy)-2-methylenecyclohexylidene)ethyl)diphenylphosphine oxide (3S,7Ξ,10Ξ)-7,10-epidioxy-9,10-seco-cholest-5-en-3-ol (R)-6-methyl-2-((1R,2R,3R)-2-methyl-2-(2-oxoethyl)-3-((phenylsulfonyl)methyl)cyclopentyl)heptanoic acid (-)-(1S,3aR,4R,7aS)-5-acetoxy-1-((phenylsulfonyl)methyl)-4-(4-methylpentyl)-3a,4,7,7a-tetrahydro-7a-methylindan 乙醚甲醇 (-)-(1(S)-methyl-2(S)-((phenylsulfonyl)methyl)-5(R)-(1(S)-((tosyloxy)methyl)-5-methylhexyl)cyclopentyl)acetaldehyde ethylene acetal (-)-2(S)-methyl-1(S)-((phenylsulfonyl)methyl)-2-(2-propenyl)-3(R)-(1(R),5-dimethylhexyl)cyclopentane

下游产品

叔丁基过氧化氢维他命D3棕榈酸酯维生素 D3 叔丁基[3-[2-(二苯基膦酰)亚乙基]-4-亚甲基环己基氧基]二甲基硅烷骨化二醇 {[(3Z)-3-(2-Chloroethylidene)-4-methylenecyclohexyl]oxy}(dimethyl )(2-methyl-2-propanyl)silane