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骨化二醇

骨化二醇

CAS号：19356-17-3

英文名：calcidiol

分子式

C27H44O2

熔点

密度

1.01 g/cm3

分子量

400.637

沸点

529.2ºC at 760 mmHg

溶解度

信号词

Danger

危险品标志

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化合物简介

Calcifediol (INN), also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D (abbreviated 25(OH)D), is a prehormone that is produced in the liver by hydroxylation of vitamin D3 (cholecalciferol) by the enzyme cholecalciferol 25-hydroxylase which was isolated by Michael F. Holick. Physicians worldwide measure this metabolite to determine a patient's vitamin D status. At a typical daily intake of vitamin D3, its full conversion to calcifediol takes approximately 7 days.

基本信息

中文名称

骨化二醇

英文名称

calcidiol

中文别名

25-羟基维生素D3、骨化三醇

英文别名

25-Hydroxycholecalciferol、Calcidiol,Didrogyl,Hidroferol、Calcifediol、Vitamin D3 25 Calcifediol、Calcifediol,(εR,1R,3aS,4E,7aR)-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]octahydro-α,α,ε,7a-tetramethyl-1H-indene-1-pentanol、25-Hydroxyvitamin D3

CAS号

19356-17-3

分子式

C27H44O2

分子量

400.637

精确质量

400.334

PSA

40.46

LOGP

6.7339

编号系统

MDL号

MFCD00867077

PubChem号

24895612

EINECS号

242-990-9

物化性质

密度

1.01 g/cm3

沸点

529.2ºC at 760 mmHg

闪点

221.4ºC

储存条件

-20ºC

安全信息

安全说明

28-36/37-45

WGK Germany

3

危险类别码

R28

危险品运输编码

UN 2811 6

危险品标志

T+

危险标志

GHS02, GHS07

危险性描述

H225; H319

危险性防范说明

P210; P280; P305 + P351 + P338; P337 + P313; P403 + P235

信号词

Danger

合成路线

共找到2条合成路线 >

3β,25-dihydroxy-9,10-secocholesta-5(E),7(E),10(19)-triene

3β,25-dihydroxy-9,10-secocholesta-5(E),7(E),10(19)-triene

骨化二醇

上游原料

共找到40个上游原料 >

(6S)-1-(((1R,7aR,E)-1-((S)-1-hydroxypropan-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)methyl)-6-((triethylsilyl)oxy)-1,3,4,5,6,7-hexahydrobenzo[c]thiophene 2,2-dioxide

(6S)-1-(((1R,7aR,E)-1-((S)-1-hydroxypropan-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)methyl)-6-((triethylsilyl)oxy)-1,3,4,5,6,7-hexahydrobenzo[c]thiophene 2,2-dioxide

(6S)-1-(((1R,3aS,7aR,E)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)methyl)-6-((triethylsilyl)oxy)-1,3,4,5,6,7-hexahydrobenzo[c]thiophene 2,2-dioxide

(6S)-1-(((1R,3aS,7aR,E)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)methyl)-6-((triethylsilyl)oxy)-1,3,4,5,6,7-hexahydrobenzo[c]thiophene 2,2-dioxide

(1R-(1α(R*),3aβ,4α((E)-(1R*,5R*)),7aα))-1-(1,5-dimethyl-5-((trimethylsilyl)oxy)hexyl)octahydro-7a-methyl-4-(2-(2-methylenebicyclo(3.1.0)hexan-1-yl)ethenyl)-1H-inden-4-ol

(1R-(1α(R*),3aβ,4α((E)-(1R*,5R*)),7aα))-1-(1,5-dimethyl-5-((trimethylsilyl)oxy)hexyl)octahydro-7a-methyl-4-(2-(2-methylenebicyclo(3.1.0)hexan-1-yl)ethenyl)-1H-inden-4-ol

(3beta,5Z,7E)-3-(叔-丁基二甲基硅烷基氧基)-9,10-开环胆甾-5,7,10(19)-三烯-24-羧酸甲酯

(3beta,5Z,7E)-3-(叔-丁基二甲基硅烷基氧基)-9,10-开环胆甾-5,7,10(19)-三烯-24-羧酸甲酯

Toluene-4-sulfonic acid (S)-2-{(1R,3aS,7aR)-4-[1-(2,2-dioxo-6-triethylsilanyloxy-2,3,4,5,6,7-hexahydro-1H-2λ6-benzo[c]thiophen-1-yl)-meth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propyl ester

Toluene-4-sulfonic acid (S)-2-{(1R,3aS,7aR)-4-[1-(2,2-dioxo-6-triethylsilanyloxy-2,3,4,5,6,7-hexahydro-1H-2λ6-benzo[c]thiophen-1-yl)-meth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propyl ester

6(S),19-(N,N'-phthalhydrazido)-3β-acetoxy-9,10-secoergosta-5(10),7(E),22(E)-triene

6(S),19-(N,N'-phthalhydrazido)-3β-acetoxy-9,10-secoergosta-5(10),7(E),22(E)-triene

下游产品

共找到2个下游商品 >

骨化三醇

(3S,5E,7E,14Xi)-3-{[二甲基(2-甲基-2-丙基)硅烷基]氧基}-9,10-开链胆甾-5,7,10-三烯-25-醇

(3S,5E,7E,14Xi)-3-{[二甲基(2-甲基-2-丙基)硅烷基]氧基}-9,10-开链胆甾-5,7,10-三烯-25-醇

上游原料

(6S)-1-(((1R,7aR,E)-1-((S)-1-hydroxypropan-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)methyl)-6-((triethylsilyl)oxy)-1,3,4,5,6,7-hexahydrobenzo[c]thiophene 2,2-dioxide (6S)-1-(((1R,3aS,7aR,E)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)methyl)-6-((triethylsilyl)oxy)-1,3,4,5,6,7-hexahydrobenzo[c]thiophene 2,2-dioxide (1R-(1α(R*),3aβ,4α((E)-(1R*,5R*)),7aα))-1-(1,5-dimethyl-5-((trimethylsilyl)oxy)hexyl)octahydro-7a-methyl-4-(2-(2-methylenebicyclo(3.1.0)hexan-1-yl)ethenyl)-1H-inden-4-ol (3beta,5Z,7E)-3-(叔-丁基二甲基硅烷基氧基)-9,10-开环胆甾-5,7,10(19)-三烯-24-羧酸甲酯 Toluene-4-sulfonic acid (S)-2-{(1R,3aS,7aR)-4-[1-(2,2-dioxo-6-triethylsilanyloxy-2,3,4,5,6,7-hexahydro-1H-2λ6-benzo[c]thiophen-1-yl)-meth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propyl ester 6(S),19-(N,N'-phthalhydrazido)-3β-acetoxy-9,10-secoergosta-5(10),7(E),22(E)-triene [1R-[1alpha(R*),3abeta,7aalpha]]-八氢-delta,7a-二甲基-4-氧代-1H-茚-1-戊酸甲酯 [1R-[1α(R*),3aβ,4α(1R*,5R*),7aα]]-1-[1,5-dimethyl-5-[(trimethylsilyl)oxy]hexyl]octahydro-7a-methyl-4-[(2-methylenebicyclo[3.1.0]hexan-1-yl)ethynyl]-1H-inden-4-ol (3beta,9Xi,14Xi,17Xi,22E)-3-{[二甲基(2-甲基-2-丙基)硅烷基]氧基}麦角甾-5,7,22-三烯 3β-((triethylsilyl)oxy)-20(S)-(hydroxymethyl)-9,10-secopregna-5(E),7(E),10(19)-triene 4-(3-acetyloxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid (3S,5Z,7E,14Xi,22E)-9,10-开环麦角甾-5,7,10,22-四烯-3-基乙酸酯 6(S),19-(N,N'-phthalhydrazido)-3β-acetoxy-25-hydroxy-9,10-secocholesta-5(10),7(E),22(Z)-triene [S-(1α,2β,5α)]-1-[(trimethylsilyl)ethynyl]bicyclo[3.1.0]hexan-2-ol 6(S),19-(N,N'-phthalhydrazido)-3,25-dihydroxy-9,10-secocholesta-5(10),7(E)-diene 3β-tert-Butyldimethylsilyloxy-25-trimethylsilyloxycholesta-5,7-diene 维生素D2 3β-((tert-butyldimethylsilyl)oxy)-22-tosyloxy-23,24-bisn-orchol-5,7-dien (R)-2-[(trimethylsilyl)ethynyl]-2-cyclopenten-1-ol 3β-tert-Butyldimethylsilyloxy-22-hydroxy-23,24-bisnorchola-5,7-diene (1R-cis)-trimethyl((2-methylenebicyclo(3.1.0)hexyl)ethynyl)silane (deltaR,1R,3aR,4S,7aR)-八氢-4-羟基-delta,7a-二甲基-1H-茚-1-戊酸甲酯 (1S-cis)-1-<(trimethylsilyl)ethynyl>bicyclo<3.1.0>hexan-2-one 3β-((triethylsilyl)oxy)-20(S)-(((p-tolylsulfonyl)oxy)-methyl)-9,10-secopregna-5(E),7(E),10(19)-triene 叔丁基[3-[2-(二苯基膦酰)亚乙基]-4-亚甲基环己基氧基]二甲基硅烷 (3-methyl-3-((triethylsilyl)oxy)butyl)triphenylphosphonium tetraphenylborate 3β-tert-Butyldimethylsilyloxy-5α,8α-(1,4-dioxo-1,2,3,4-tetrahydro-phthalazine-2,3-diyl)ergosta-6,22-diene 麦角固醇 Methyl-3β-acetoxy-homochola-5,7-dien-25-oat (1R,3aR,4S,7aR)-八氢-1-[(1S)-2-碘-1-甲基乙基]-7a-甲基-1H-茚-4-醇 methyl 3-acetoxy-23a-homo-5-cholen-24-oate 维生素 D3 25-Hydroxyprovitamin D3 magnesium,carbanide,iodide 6(S),19-(N,N'-phthalhydrazido)-3β-acetoxy-20(S)-formyl-9,10-secopregna-5(10),7(E)-diene 维他命D2二氧化硫加合物 (2S)-2-((1R,3aS,7aR,E)-4-(((6S)-2,2-dioxido-6-((triethylsilyl)oxy)-1,3,4,5,6,7-hexahydrobenzo[c]thiophen-1-yl)methylene)-7a-methyloctahydro-1H-inden-1-yl)propanal (2S,14S)-14-((E)-((1R,3aS,7aR)-7a-methyl-1-((R,Z)-6-methyl-6-((triethylsilyl)oxy)hept-3-en-2-yl)hexahydro-1H-inden-4(2H)-ylidene)methyl)-7,12-dioxo-1,2,3,4,5,7,12,14-octahydrophthalazino[2,3-b]phthalazin-2-yl acetate 3β,25-dihydroxy-9,10-secocholesta-5(E),7(E),10(19)-triene

下游产品

骨化三醇 (3S,5E,7E,14Xi)-3-{[二甲基(2-甲基-2-丙基)硅烷基]氧基}-9,10-开链胆甾-5,7,10-三烯-25-醇