百科

骨化三醇

骨化三醇

CAS号：32222-06-3

英文名：calcitriol

分子式

C27H44O3

熔点

119-1210C

密度

1.06g/cm3

分子量

416.636

沸点

565ºC at 760 mmHg

溶解度

信号词

Danger

危险品标志

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化合物简介

骨化三醇（英语：Calcitriol，又称为1,25-二羟胆钙化醇或1,25-二羟维生素D3）是维生素D的活性形式，也是体内的一种激素，在调节血钙与血磷浓度方面有着重要作用。

基本信息

中文名称

骨化三醇

英文名称

calcitriol

中文别名

1α,25-二羟基维生素D3、1Α,25-羟胆钙化醇、(5Z,7E)-(1S,3R)-9,10-开环胆甾-5,7,10(19)-三烯-1,3,25-三醇、1α,25-Dihydroxycholecalciferol、钙三醇

英文别名

(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol、1α,25-Dihydroxyvitamin D3、1,25-Dihydroxycholecalciferol

CAS号

32222-06-3

分子式

C27H44O3

分子量

416.636

精确质量

416.329

PSA

60.69

LOGP

5.7047

编号系统

MDL号

MFCD00867079

物化性质

外观与性状

白色结晶粉末

密度

1.06g/cm3

沸点

565ºC at 760 mmHg

熔点

119-1210C

闪点

238.4ºC

折射率

1.547

储存条件

库房通风低温干燥,与食品分开储运

安全信息

RTECS号

FZ4645000

安全说明

S36/37/39-S45

危险类别码

R26/27/28; R63

WGK Germany

3

危险品运输编码

UN 2811 6.1/PG 1

海关编码

2942000000

危险类别

6.1(a)

包装等级

I

危险品标志

T+

危险性描述

H300

危险标志

GHS06

信号词

Danger

生产方法及用途

用途

用于慢性肾功能衰竭患者的肾性骨营养不良。

合成路线

共找到1条合成路线 >

(1S,3R,5E,7E,14Xi)-1,3-二{[二甲基(2-甲基-2-丙基)硅烷基]氧基}-9,10-开链胆甾-5,7,10-三烯-25-醇

(1S,3R,5E,7E,14Xi)-1,3-二{[二甲基(2-甲基-2-丙基)硅烷基]氧基}-9,10-开链胆甾-5,7,10-三烯-25-醇

骨化三醇

上游原料

共找到178个上游原料 >

25-hydroxy-de-A,B-cholest-8-en-8-yl trifluoromethanesulfonate

25-hydroxy-de-A,B-cholest-8-en-8-yl trifluoromethanesulfonate

(1S-cis)-(1,1-dimethylethoxy)-2,3,5,6,7,7a-hexahydro-7a-methyl-5-oxo-1H-indene-4-carboxylic acid

(1S-cis)-(1,1-dimethylethoxy)-2,3,5,6,7,7a-hexahydro-7a-methyl-5-oxo-1H-indene-4-carboxylic acid

(3S,5R)-3,5-bis[((tert-butyldiphenyl)silyl)oxy]-1-ethynyl-2-methylcyclohex-1-ene

(3S,5R)-3,5-bis[((tert-butyldiphenyl)silyl)oxy]-1-ethynyl-2-methylcyclohex-1-ene

[2S-(1E,2α,3β,5α)]-(2,3,5-trihydroxy-2-methylcyclohexylidene)acetic acid ethyl ester

[2S-(1E,2α,3β,5α)]-(2,3,5-trihydroxy-2-methylcyclohexylidene)acetic acid ethyl ester

Carvone-5,6-oxide,trans-(-)-

Carvone-5,6-oxide,trans-(-)-

[S-(1α,2β,5α)]-1-[(trimethylsilyl)ethynyl]bicyclo[3.1.0]hexan-2-ol

[S-(1α,2β,5α)]-1-[(trimethylsilyl)ethynyl]bicyclo[3.1.0]hexan-2-ol

下游产品

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骨化三醇杂质

骨化三醇杂质

上游原料

25-hydroxy-de-A,B-cholest-8-en-8-yl trifluoromethanesulfonate (1S-cis)-(1,1-dimethylethoxy)-2,3,5,6,7,7a-hexahydro-7a-methyl-5-oxo-1H-indene-4-carboxylic acid (3S,5R)-3,5-bis[((tert-butyldiphenyl)silyl)oxy]-1-ethynyl-2-methylcyclohex-1-ene [2S-(1E,2α,3β,5α)]-(2,3,5-trihydroxy-2-methylcyclohexylidene)acetic acid ethyl ester [S-(1α,2β,5α)]-1-[(trimethylsilyl)ethynyl]bicyclo[3.1.0]hexan-2-ol α-Phenyl-β-(methanesulfonyl)ethanesulfonyl chloride 1-((1S,3aR,7aS)-1-(tert-butoxy)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl)ethan-1-one (3S,5R)-1-ethynyl-3,5-dihydroxy-2-methylcyclohex-1-ene [1R-(1α,2E,4α,6α)]-[1-methyl-4-(1-methylethenyl)-7-oxabicyclo[4.1.0]hept-2-ylidene]acetic acid ethyl ester [3S-(1Z,3α,5β)]-2-[3,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methylenecyclohexylidene]-1-chloroethane (1S,2R,4S,6S)-2,4-diacetoxy-2-ethynyl-1-methyl-7-oxabicyclo[4.1.0]heptane (1S-cis)-1-<(trimethylsilyl)ethynyl>bicyclo<3.1.0>hexan-2-one (1S,3aR,4R,7aS)-1-(tert-butoxy)-7a-methyloctahydro-1H-inden-4-yl acetate 1α-<((tert-butyldiphenyl)silyl)oxy>-6,7-dehydro-25-hydroxyprevitamin D3 (tert-butyldiphenyl)silyl ether 骨化三醇杂质 [2S-(1E,2α,3β,5α)]-[2,3-bis(acetyloxy)-2-methyl-5-(1-methylethenyl)cyclohexylidene]acetic acid ethyl ester ethyl (R,E)-4-((3aS,7R,7aR)-7-acetoxy-3a-methyl-3a,4,5,6,7,7a-hexahydro-1H-inden-3-yl)pent-2-enoate (1S,3R,5E,7E,14Xi)-1,3-二{[二甲基(2-甲基-2-丙基)硅烷基]氧基}-9,10-开链胆甾-5,7,10-三烯-25-醇 (3aR,4R,7aS)-7a-methyl-1-oxooctahydro-1H-inden-4-yl acetate [3aR-((E), 3aα,4β,7aβ)]-1-ethylidene-octahydro-7a-methyl-1H-4-indenol [1R-[1α(R*),3aβ,7aα]]-octahydro-1-[5-[(trimethylsilyl)oxy]-1,5-dimethylhexyl]-7a-methyl-4H-inden-4-one [2S-(1E,2α,3β,5α)]-[3,5-bis[[(1,1dimethylethyl)dimethylsilyl]oxy]-2-hydroxy-2-methylcyclohexylidene]acetic acid ethyl ester 1,1-dimethoxy-3-(tert-diphenylsiloxy)-5-hexyne de-A,B-25-cholesta-8,25-dien-8-yl trifluromethanesulfonate 1-((1S,3aS,4S,5S,7aS)-1-(tert-butoxy)-5-hydroxy-7a-methyloctahydro-1H-inden-4-yl)ethan-1-one 3-((tert-butyldiphenylsilyl)oxy)hex-5-ynal 甲基锂 (3S,5R)-3,5-bis<((tert-butyldiphenyl)silyl)oxy>-1-ethenyl-2-methylcyclohex-1-ene (1S,6R)-1-hydroxy-6-(1,3-benzodithiol-2-yloxy)-25-tetrahydropyranyloxy-3,5-cyclovitamin D3 (R)-2-[(trimethylsilyl)ethynyl]-2-cyclopenten-1-ol (1S,3aS,4S,5S,7aS)-1-(tert-butoxy)-5-hydroxy-7a-methyloctahydro-1H-indene-4-carboxylic acid (1R-cis)-trimethyl((2-methylenebicyclo(3.1.0)hexyl)ethynyl)silane (+/-)-1β-tert.-Butoxy-3aα,4β,5,6,7,7a-hexahydro-7aβ-methyl-5-oxo-4-indancarbonsaeure (((1R,3S,Z)-5-(2-((1R,3aS,7aR,E)-1-((R)-6-(methoxymethoxy)-6-methylheptan-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diyl)bis(oxy))bis(triisopropylsilane) (2S-(1E,2α,3β,5α))-(2,3,5-tris(acetyloxy)-2-methylcyclohexylidene)acetic acid ethyl ester 1,1-diethoxy-3-(tert-butyldiphenylsiloxy)-5-hexyne 1-((1S,3aS,4R,7aS)-1-(tert-butoxy)-7a-methyloctahydro-1H-inden-4-yl)ethan-1-one (3S,5R)-3,5-bis[((tert-butyldiphenyl)silyl)oxy]-1-(2,2-dibromoethenyl)-2-2-methylcyclohex-1-ene 1,1-diethoxy-3-hydroxy-5-hexyne 7,8-cis-1α,25-dihydroxyvitamin D3 (3aR,4R,7aS,Z)-1-ethylidene-7a-methyloctahydro-1H-inden-4-yl acetate [2S-(1E,2α,3β,5α)]-[5-acetyl-2,3-bis(acetyloxy)-2-methyl-cyclohexylidene]acetic acid ethyl ester 25-oxo-27-nor-1α(OH)D3 [1S-(1β,3aα,4β,7aβ)]-7a-methyl-octahydro-1H-indene-1,4-diol 4-acetate

下游产品

骨化三醇杂质