化合物简介
Mestranol (INN, USAN, BAN, JAN) (brand names Devocin, Ovastol, Tranel), also known as ethinyl estradiol methyl ether (EEME), is a synthetic, steroidal estrogen that has been widely used medically. It was employed as the estrogen component in many of the first oral contraceptives, such as mestranol/noretynodrel (brand names Enovid, Enavid), and is still in use today. It was also a component of Ortho-Novin, Femigen, and Norbiogest. In addition to its use as an oral contraceptive, mestranol has been used as a component of hormone replacement therapy.
基本信息
中文名称
美雌醇
英文名称
mestranol
中文别名
(17α)-3-Methoxy-19-norpregna-1,3,5(10)-trien-20-yn-17-ol、3-甲氧基-17α-乙炔雌二醇、炔雌醇甲醚
英文别名
SC 4725、Norquen、RS 1044、d-MVE、EE3ME、19-Norpregna-1,3,5(10)-trien-20-yn-17-ol, 3-methoxy-, (17 -)-、17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether、Mestranol、Devocin、Ovastol
CAS号
72-33-3
分子式
C21H26O2
分子量
310.43
精确质量
310.193
PSA
29.46
LOGP
3.9156
编号系统
UNII
B2V233XGE7
物化性质
外观与性状
结晶固体
密度
0.905g/cm3
沸点
464.1ºC at 760 mmHg
熔点
153-155°C(lit.)
闪点
224.1ºC
折射率
1.49
储存条件
-20ºC Freezer
安全信息
RTECS号
RC8960000
安全说明
S22; S26; S36/37/39; S45; S36/37
WGK Germany
3
危险类别码
R36/37/38; R40; R48
危险品标志
Xn
危险性描述
H315; H319; H351
危险标志
GHS07, GHS08
信号词
Warning
危险性防范说明
P281; P305 + P351 + P338
生产方法及用途
用途
主要用于卵巢功能不全、闭经、功能性子宫出血、更年期综合征等。
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