百科

剑麻皂素

CAS号：77-60-1

英文名：(25R)-5.α.-Spirostan-3.β.-ol

分子式

C27H44O3

熔点

202-204ºC

密度

1.11 g/cm3

分子量

416.636

沸点

516.6ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

Tigogenin is a saponin structurally similar to Diosgenin and acts as a natural plant steroid which induces apoptosis in rheumatoid arthritic fibroblast-like synoviocytes.

基本信息

中文名称

剑麻皂素

英文名称

(25R)-5.α.-Spirostan-3.β.-ol

中文别名

剑麻皂苷元、(25R)-5α-螺甾(烷)-3β-醇、(3β,5α,25R)-3-羟基-螺甾(烷)、替柯吉宁

英文别名

TIGOGENIN、Ticogenin、Tsosarsasaprgein、Sisalagenin、Trigonegenin B、Spirostan-3-ol, (3β,5α,25R)-

CAS号

77-60-1

分子式

C27H44O3

分子量

416.636

精确质量

416.329

PSA

38.69

LOGP

5.7938

编号系统

MDL号

MFCD00067287

物化性质

外观与性状

白色,微结晶粉末

密度

1.11 g/cm3

沸点

516.6ºC at 760 mmHg

熔点

202-204ºC

闪点

266.2ºC

折射率

1.3047 (20ºC)

稳定性

Stable at normal temperatures and pressures.

储存条件

Keep tightly closed. Store in a cool dry place.

安全信息

RTECS号

WH1443500

海关编码

2932999099

危险类别

2.3

生产方法及用途

用途

双炔失碳丙酯;去氢甲基睾丸素;康复龙等的原料。

合成路线

上游原料

(E)-1-(tert-butyldimethylsilyl)-2-((2aS,4S,5'R,6aS,6bS,8aS,8bR,9S,10R,11aS,12aS,12bR)-4-((tert-butyldimethylsilyl)oxy)-5',6a,8a,9-tetramethylicosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-8(2H)-ylidene)hydrazine

75657-39-5

O-β-D-Glucopyranosyl-tigogenin

下游产品

3beta-羟基孕甾-16-烯-20-酮-3-醋酸酯

17916-30-2

3beta-羟基孕甾-5-烯-20-酮肟 3-乙酸酯

571-20-0

5alpha-雄烷二醇

上游原料

desmettianoside A (25R)-5a-螺甾烷-3-酮 (E)-1-(tert-butyldimethylsilyl)-2-((2aS,4S,5'R,6aS,6bS,8aS,8bR,9S,10R,11aS,12aS,12bR)-4-((tert-butyldimethylsilyl)oxy)-5',6a,8a,9-tetramethylicosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-8(2H)-ylidene)hydrazine O-β-D-Glucopyranosyl-tigogenin Neotigogenin acetate 异丙醇铝刺蒺藜素龙舌兰皂苷乙酯隐配质 neotigogenin 3-O-[O-β-D-glucopyranosyl-(1->4)-β-D-galactopyranoside] 异丙醇薯蓣皂素皂素正戊醇 (25R)-5α-furost-22ξ-ene-3β,26-diol (25R)-5α-spirostan-3β-ol 3-O-β-D-galactopyranoside 3-O-β-D-glucopyranosyl-(1->3)[β-D-fucopyranosyl-(1->2)]-β-D-glucopyranosyl-(1->4)-β-D-galactopyranosyl-(25R),5α-furostan-3β,22α,26-triol-26-O-β-D-glucopyranoside 醋酸乙醇 (25R)-3β.26-dihydroxy-5α-cholestanedione-(16.22) (25R)-5α-spirostan-3β-ol 3-O-[O-β-D-glucopyranosyl(1 -> 4)-β-D-galactopyranoside] (23S,25S)-23-bromo-spirost-4-en-3-one 乙二醇 (25S)-3β-hydroxy-5β-spirostan-23-one Diosgenin-acetat 水合肼 (25R)-22-ethoxy-5α,22αH-furostan-3β,26-diol 2,3,4-Tri-O-acetyl-1,5-anhydro-6-deoxy-L-arabino-hex-1-enitol (25R)-5alpha-螺甾烷-3beta-基乙酸酯乙醚 desmettianoside B (25R)-3β,26-diacetoxy-5α-cholestane-16,22-dione (3alpha,5alpha,25R)-螺甾烷-3-醇

下游产品

醋酸去氢表雄酮 3beta-羟基孕甾-16-烯-20-酮-3-醋酸酯 3beta-羟基孕甾-5-烯-20-酮肟 3-乙酸酯 5alpha-雄烷二醇