化合物简介
5α-Androstane-3β,17β-diol, also called 3β-androstanediol, and often shortened to 3β-diol, is an endogenous steroid hormone. It is a 5α-reduced and 17β-hydroxylated metabolite of dehydroepiandrosterone (DHEA) as well as a 3β-hydroxylated metabolite of dihydrotestosterone (DHT). 3β-Diol is a selective, potent, high-affinity full agonist of the ERβ, and hence, an estrogen. It has higher affinity for this receptor than estradiol. In contrast to ERβ, 3β-diol does not bind to the androgen receptor (AR). 3β-Diol has been reported to also bind to ERα with low nanomolar affinity, with several-fold lower affinity relative to ERβ. Unlike its 3α-isomer, 3α-androstanediol (3α-diol), 3β-diol does not bind to the GABAA receptor.
基本信息
中文名称
5alpha-雄烷二醇
英文名称
5α-androstane-3β,17β-diol
中文别名
二氫雄甾酮、5α-雄甾烷-3β,17β-二醇、5a-雄烷二醇、5A-雄烷-3B,17B-二醇、5α-雄烷二醇
英文别名
5alpha-androstane-3beta,17beta-diol、5α-Androstane-3β,17β-diol、(3S,5S,8R,9S,10S,13S,14S,17S)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,17-diol
CAS号
571-20-0
分子式
C19H32O2
分子量
292.456
精确质量
292.24
PSA
40.46
LOGP
3.7509
编号系统
UNII
6J0K4253QD
物化性质
密度
1.09g/cm3
沸点
415ºC at 760mmHg
熔点
121-128°C(lit.)
闪点
186ºC
折射率
1.546
储存条件
库房通风低温干燥
安全信息
RTECS号
BV8044320
安全说明
S24; S45
危险类别码
R36/38
危险品标志
Xi
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