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表雄酮

表雄酮

CAS号：481-29-8

英文名：epiandrosterone

分子式

C19H30O2

熔点

172-174°C

密度

1.085 g/cm3

分子量

290.44

沸点

413.1ºC at 760 mmHg

溶解度

practically insoluble

信号词

危险品标志

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化合物简介

Epiandrosterone, or 3β-androsterone, also known as 3β-hydroxy-5α-androstan-17-one or 5α-androstan-3β-ol-17-one, is a steroid hormone with weak androgenic activity. It is a natural metabolite of dehydroepiandrosterone (DHEA) via the 5α-reductase enzyme. It was first isolated in 1931, by Adolf Friedrich Johann Butenandt and Kurt Tscherning. They distilled over 17,000 litres of male urine, from which they got 50 milligrams of crystalline androsterone (most likely mixed isomers), which was sufficient to find that the chemical formula was very similar to estrone.

基本信息

中文名称

表雄酮

英文名称

epiandrosterone

中文别名

表雄甾酮、5α-雄甾-3β-醇-17-酮、异雄甾酮、异雄酮,异雄酮、METHYL MASTERDROL

英文别名

3BETA-HYDROXY-5ALPHA-ANDROSTAN-17-ONE、ISOANDROSTERONE、D-epiandrosterone、3b-Androsterone、TRANS-ANDROSTERONE、Androstan-17-one, 3-hydroxy-, (3β,5α)-、trans-Androsterone、3beta-Androsterone、epiandrosteron、EPLANDROSTERONE、Epiandrosterone

CAS号

481-29-8

分子式

C19H30O2

分子量

290.44

精确质量

290.225

PSA

37.3

LOGP

3.9591

编号系统

UNII

8TR252Z538

物化性质

外观与性状

白色至灰白色结晶粉末

密度

1.085 g/cm3

沸点

413.1ºC at 760 mmHg

熔点

172-174°C

闪点

176.4ºC

折射率

1.536

水溶解性

practically insoluble

稳定性

Stable under normal temperatures and pressures.

储存条件

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Hormones and antibiotics room.

蒸汽压

0mmHg at 25°C

安全信息

安全说明

S22-S24/25

WGK Germany

3

海关编码

2937290090

生产方法及用途

生产方法

用5-雄甾烯-3β-醇-17-酮3-醋酸酯以钯炭催化氢化,得雄甾烷-3β-醇-17酮3-醋酸酯,然后以氢氧化钠溶液水解,制得该品。

用途

生产甾体激素类药物。

合成路线

共找到40条合成路线 >

[(3S,5S,8R,9S,10S,13R,14S,17R)-17-[(2R,5R)-5-ethyl-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate

[(3S,5S,8R,9S,10S,13R,14S,17R)-17-[(2R,5R)-5-ethyl-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate

表雄酮

24-去甲石胆酸

24-去甲石胆酸

上游原料

共找到55个上游原料 >

醋酸去氢表雄酮

醋酸去氢表雄酮

4-雄烯二醇

3beta-羟基孕甾-16-烯-20-酮-3-醋酸酯

3beta-羟基孕甾-16-烯-20-酮-3-醋酸酯

表雄酮

下游产品

共找到28个下游商品 >

17α-甲基雄甾-17β-醇-3-酮

17α-甲基雄甾-17β-醇-3-酮

醋酸去氢表雄酮

醋酸去氢表雄酮

(5α,17α,20E)-21-iodopregn-20-ene-3β,17β-diol

(5α,17α,20E)-21-iodopregn-20-ene-3β,17β-diol

9-fluoro-11,17-dihydroxy-10,13,17-trimethyl-1,2,4,5,6,7,8,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one

9-fluoro-11,17-dihydroxy-10,13,17-trimethyl-1,2,4,5,6,7,8,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one

5-雄甾-3-烯-17-酮

5-雄甾-3-烯-17-酮

(5alpha)-17,21-二羟基孕甾烷e-3,20-二酮

(5alpha)-17,21-二羟基孕甾烷e-3,20-二酮

上游原料

醋酸去氢表雄酮 4-雄烯二醇睾酮水 3beta-羟基孕甾-16-烯-20-酮-3-醋酸酯表雄酮乙醇钠 epiandrosterone benzoate 3beta-乙酰氧基-17-羟基-5alpha-孕甾烷-20-酮 [(3S,6R)-6-[(8R,9S,10S,13R,14S,17R)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2,3-dimethylheptyl] acetate 乙醇 2-((ethoxycarbonyl)amino)quinoline 1-oxide 雄烯二酮 3β-acetoxy-23,24-dinor-5α-cholane-17,20-diol (3β,5α)-3-hydroxyandrostan-17-one oxime 17-Methyl 3β-hydroxy-16,17-seco-5α-androstane-16,17-dioic acid 3β-acetoxy-16β-bromo-17-hydroxy-5α-pregnan-20-one Dimethyl 3β-hydroxy-16,17-seco-5α-androstane-16,17-dioate 雄甾-1,4-二烯-3,17-二酮 (3beta,5alpha)-胆甾烷-3-基乙酸酯 (3S,5S,8R,9S,10S,13S,14S,E)-10,13-dimethyl-17-(methylimino)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl benzoate racem. trans-5,6-Dimethoxy-1,3-cyclohexadien 3β-hydroxy-10.13-dimethyl-17-isopropylidene-5α-gonane 醋酸去氢素雄酮乙酸乙酯 17α-cyano-17β-hydroxyandrost-4-en-3-one trans-4,5-dibromocyclohexane-cis-1,2-diol 3β-Hydroxy-16,17-seco-5α-androstane-16,17-dioic acid 5α-二氢睾酮 5β-pregnene-(17(20)c)-diyl-(3β.20)-diacetate 5alpha-胆甾烷-3beta-醇苯甲酸酯 5alpha-雄烷二醇醋酸 5a-雄甾烷二酮 (3S,5S,8R,9S,10S,13S,14S)-10,13-dimethyl-3-((tetrahydrofuran-2-yl)oxy)tetradecahydro-1H-cyclopenta[a]phenanthren-17(2H)-one 6-[[[5-(2,4-二氧代嘧啶-1-基)-3,4-二羟基四氢呋喃-2-基]甲氧基-羟基磷酰]氧基-羟基磷酰]氧基-3,4,5-三羟基四氢吡喃-2-羧酸 17-Methylene-3β-hydroxy-5α-androstane 16α,17α-epoxypregnan-20-one-3β-ol 3-acetate 3β-acetoxy-17ξ-nitro-5α,13α-androstane [(3S,5S,8R,9S,10S,13R,14S,17R)-17-[(2R,5R)-5-ethyl-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate 甲醇别孕烯醇酮去氢表雄酮雄酮 2α-Methoxycarbonyl-tetradecahydro-7β-acetoxy-2β.4b-dimethyl-1β-phenanthrenessigsaeure 1,2-Dibrom-trans-4,5-dimethoxycyclohexan 3β-hydroxy-16,17-secoandrost-5-ene-16,17-dioic acid 氢溴酸

下游产品

17α-甲基雄甾-17β-醇-3-酮醋酸去氢表雄酮 (5α,17α,20E)-21-iodopregn-20-ene-3β,17β-diol 9-fluoro-11,17-dihydroxy-10,13,17-trimethyl-1,2,4,5,6,7,8,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one 5-雄甾-3-烯-17-酮 (5alpha)-17,21-二羟基孕甾烷e-3,20-二酮 (3S,5S,8R,9S,10S,13S,14S,17R)-17-Ethynyl-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthrene-3,17-diol 乙基3-[(4S)-2,2-二甲基-1,3-二氧戊环-4-基]丙酸酯 5α-Androst-2-en-17-one 3β-hydroxy-13,17-seco-5α-androst-13-en-17-aldehyde 3β,19-oxido-5α-androstan-17-one (5S,8R,9S,10S,13S,14S)-17-羟基-17-[(E)-2-碘乙烯基]-10,13-二甲基-2,4,5,6,7,8,9,11,12,14,15,16-十二氢-1H-环戊二烯并[a]菲-3-酮 5α.17βH-pregnanediol-(3β.17) 5alpha-雄烷二醇 5a-雄甾烷二酮 (3beta,5beta,17alpha)-雄甾烷-3,17-二醇 3β,14α-dihydroxy-5α-androstan-17-one androsterone 孕甾-4-烯-17Alpha,21-二醇-3,20-二酮-21-醋酸酯 17-hydroxy-10,13,17-trimethyl-2,4,5,6,7,8,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one [(8R,9S,10S,13S,14S)-17-acetyloxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate 雄酮 3β,5α-dihydroxy-5α-androstan-17-one 3β-tert-Butyldimethylsilyloxy Epiandrosterone 雄烯酮 (5S,8S,9R,10S,13S,14S,17S)-9-氟-17-羟基-10,13,17-三甲基-2,4,5,6,7,8,12,14,15,16-十氢-1H-环戊并[a]菲-3,11-二酮