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冈田(软海绵)酸

冈田(软海绵)酸

CAS号：78111-17-8

英文名：okadaic acid

分子式

C44H68O13

熔点

164-166ºC

密度

1.28 g/cm3

分子量

805.003

沸点

921.6ºC at 760 mmHg

溶解度

信号词

Danger

危险品标志

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化合物简介

Okadaic acid, C44H68O13, is a toxin produced by several species of dinoflagellates, and is known to accumulate in both marine sponges and shellfish. One of the primary causes of diarrhetic shellfish poisoning, okadaic acid is a potent inhibitor of specific protein phosphatases and is known to have a variety of negative effects on cells. A polyketide, polyether derivative of a C38 fatty acid, okadaic acid and other members of its family have shined light upon many biological processes both with respect to dinoflagellete polyketide synthesis as well as the role of protein phosphatases in cell growth.

基本信息

中文名称

冈田(软海绵)酸

英文名称

okadaic acid

中文别名

冈田酸、黑海棉酸

英文别名

OKADAIC ACID、OKADAICACID,HIGHPURITY、Ocadaic Acid、9,10-deepithio-9,10-didehydroacanthifolicin、okadaic acd、Okadic acid

CAS号

78111-17-8

分子式

C44H68O13

分子量

805.003

精确质量

804.466

PSA

182.83

LOGP

5.2136

编号系统

EINECS号

616-589-8

物化性质

外观与性状

白色晶体或粉末

密度

1.28 g/cm3

沸点

921.6ºC at 760 mmHg

熔点

164-166ºC

闪点

269.4ºC

折射率

1.584

稳定性

Stable. Light and heat-sensitive. Combustible. Incompatible with strong oxidizing agents.

储存条件

库房低温,通风,干燥,与食品原料分开存放

安全信息

RTECS号

AA8227800

危险类别码

R23/24/25

WGK Germany

3

危险品运输编码

UN 3462 6

危险类别

6.1(a)

包装等级

II

危险品标志

T

危险性描述

H301; H311; H315; H331

危险标志

GHS06

危险性防范说明

P261; P280; P301 + P310; P311

信号词

Danger

合成路线

tribenzyl okadaic acid

tribenzyl okadaic acid

冈田(软海绵)酸

冈田(软海绵)酸

上游原料

共找到61个上游原料 >

((2S,5R,6S,8S)-5-(benzyloxy)-8-((R)-1-((4-methoxybenzyl)oxy)propan-2-yl)-10-methyl-1,7-dioxaspiro[5.5]undec-10-en-2-yl)methanol

((2S,5R,6S,8S)-5-(benzyloxy)-8-((R)-1-((4-methoxybenzyl)oxy)propan-2-yl)-10-methyl-1,7-dioxaspiro[5.5]undec-10-en-2-yl)methanol

(1R,3S)-1-{(2S,4R,4aR,6R,8aR)-4-Benzyloxy-6-methoxy-6-[3-(4-methoxy-benzyloxy)-propyl]-3-methylene-octahydro-pyrano[3,2-b]pyran-2-yl}-3-((2S,3R,6S)-3-methyl-1,7-dioxa-spiro[5.5]undec-2-yl)-butan-1-ol

(1R,3S)-1-{(2S,4R,4aR,6R,8aR)-4-Benzyloxy-6-methoxy-6-[3-(4-methoxy-benzyloxy)-propyl]-3-methylene-octahydro-pyrano[3,2-b]pyran-2-yl}-3-((2S,3R,6S)-3-methyl-1,7-dioxa-spiro[5.5]undec-2-yl)-butan-1-ol

(3R,6S)-3-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-2-one

(3R,6S)-3-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-2-one

(Z)-(2S,5R,10S,11R)-5-Benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-12-(4-methoxy-benzyloxy)-8,11-dimethyl-2,10-bis-trimethylsilanyloxy-dodec-7-en-6-one

(Z)-(2S,5R,10S,11R)-5-Benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-12-(4-methoxy-benzyloxy)-8,11-dimethyl-2,10-bis-trimethylsilanyloxy-dodec-7-en-6-one

(2S,5R)-5-({(2S,5R,6S,8S)-5-Benzyloxy-8-[(R)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-10-methyl-1,7-dioxa-spiro[5.5]undec-10-en-2-yl}-hydroxy-methyl)-2-tert-butyl-5-methyl-[1,3]dioxolan-4-one

(2S,5R)-5-({(2S,5R,6S,8S)-5-Benzyloxy-8-[(R)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-10-methyl-1,7-dioxa-spiro[5.5]undec-10-en-2-yl}-hydroxy-methyl)-2-tert-butyl-5-methyl-[1,3]dioxolan-4-one

(4S,9R,12S)-9-(benzyloxy)-12-hydroxy-4-((R)-1-((4-methoxybenzyl)oxy)propan-2-yl)-2,2,16,16-tetramethyl-15,15-diphenyl-3,14-dioxa-2,15-disilaheptadec-6-yn-8-one

(4S,9R,12S)-9-(benzyloxy)-12-hydroxy-4-((R)-1-((4-methoxybenzyl)oxy)propan-2-yl)-2,2,16,16-tetramethyl-15,15-diphenyl-3,14-dioxa-2,15-disilaheptadec-6-yn-8-one

上游原料

((2S,5R,6S,8S)-5-(benzyloxy)-8-((R)-1-((4-methoxybenzyl)oxy)propan-2-yl)-10-methyl-1,7-dioxaspiro[5.5]undec-10-en-2-yl)methanol (1R,3S)-1-{(2S,4R,4aR,6R,8aR)-4-Benzyloxy-6-methoxy-6-[3-(4-methoxy-benzyloxy)-propyl]-3-methylene-octahydro-pyrano[3,2-b]pyran-2-yl}-3-((2S,3R,6S)-3-methyl-1,7-dioxa-spiro[5.5]undec-2-yl)-butan-1-ol (3R,6S)-3-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-2-one (Z)-(2S,5R,10S,11R)-5-Benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-12-(4-methoxy-benzyloxy)-8,11-dimethyl-2,10-bis-trimethylsilanyloxy-dodec-7-en-6-one (2S,5R)-5-({(2S,5R,6S,8S)-5-Benzyloxy-8-[(R)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-10-methyl-1,7-dioxa-spiro[5.5]undec-10-en-2-yl}-hydroxy-methyl)-2-tert-butyl-5-methyl-[1,3]dioxolan-4-one (4S,9R,12S)-9-(benzyloxy)-12-hydroxy-4-((R)-1-((4-methoxybenzyl)oxy)propan-2-yl)-2,2,16,16-tetramethyl-15,15-diphenyl-3,14-dioxa-2,15-disilaheptadec-6-yn-8-one {(2S,4R,4aR,6R,8aR)-4-Benzyloxy-6-methoxy-6-[3-(4-methoxy-benzyloxy)-propyl]-3-methylene-octahydro-pyrano[3,2-b]pyran-2-ylmethoxy}-tert-butyl-dimethyl-silane (2R,3R)-3,4-diethylmethylenedioxy-2-methyl-butan-1-ol (2S,5R)-5-(((2S,5R,6R,8S)-5-(benzyloxy)-8-((R)-1-((4-methoxybenzyl)oxy)propan-2-yl)-10-methyl-1,7-dioxaspiro[5.5]undec-10-en-2-yl)methyl)-2-(tert-butyl)-5-methyl-1,3-dioxolan-4-one (S)-2-((2S,6R,8S,11R)-11-(benzyloxy)-8-(((2S,4R)-2-(tert-butyl)-4-methyl-5-oxo-1,3-dioxolan-4-yl)methyl)-4-methyl-1,7-dioxaspiro[5.5]undec-4-en-2-yl)propanal (R)-2,2-Diethyl-4-[(R)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-[1,3]dioxolane (2R,4a'R,5R,6'S,7'S,8'R,8a'R)-7'-(benzyloxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-8'-(methoxymethoxy)octahydro-3H,3'H-spiro[furan-2,2'-pyrano[3,2-b]pyran]-6'-carbaldehyde (((2R,4a'R,5R,6'S,8'R,8a'R)-8'-(benzyloxy)-6'-((1S,3S)-1-(benzyloxy)-3-((2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl)butyl)-7'-methyleneoctahydro-3H,3'H-spiro[furan-2,2'-pyrano[3,2-b]pyran]-5-yl)methoxy)(tert-butyl)diphenylsilane dimethyl (4-((2S,4aR,6S,8R,8aR)-8-(benzyloxy)-6-((1S,3S)-1-(benzyloxy)-3-((2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl)butyl)-2-methoxy-7-methyleneoctahydropyrano[3,2-b]pyran-2-yl)-2-oxobutyl)phosphonate (2R,4aR,6S,8R,8aR)-8-Benzyloxy-6-[(1S,3S)-1-benzyloxy-3-((2S,3R,6S)-3-methyl-1,7-dioxa-spiro[5.5]undec-2-yl)-butyl]-2-methoxy-2-[3-(4-methoxy-benzyloxy)-propyl]-7-methylene-octahydro-pyrano[3,2-b]pyran (1S,3S)-1-((2R,4a'R,5R,6'R,7'R,8'R,8a'R)-7'-(benzyloxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-8'-(methoxymethoxy)octahydro-3H,3'H-spiro[furan-2,2'-pyrano[3,2-b]pyran]-6'-yl)-3-((2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl)butan-1-ol (6R)-1-((4aR,6R,7R,8S,8aR)-7-(benzyloxy)-8-(methoxymethoxy)-2-phenylhexahydropyrano[3,2-d][1,3]dioxin-6-yl)-7-((tert-butyldiphenylsilyl)oxy)-6-(1-ethoxyethoxy)heptan-3-one 3-((2S,4aR,6S,8R,8aR)-8-(benzyloxy)-6-((1S,3S)-1-(benzyloxy)-3-((2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl)butyl)-2-methoxy-7-methyleneoctahydropyrano[3,2-b]pyran-2-yl)propanal (2S,5R)-5-((S)-((2S,5R,6S,8S)-5-(benzyloxy)-8-((R)-1-((4-methoxybenzyl)oxy)propan-2-yl)-10-methyl-1,7-dioxaspiro[5.5]undec-10-en-2-yl)(hydroxy)methyl)-2-(tert-butyl)-5-methyl-1,3-dioxolan-4-one (1S,3S)-1-((2S,4R,4aR,6R,8aR)-4-(benzyloxy)-6-methoxy-6-(3-((4-methoxybenzyl)oxy)propyl)-3-methyleneoctahydropyrano[3,2-b]pyran-2-yl)-3-((2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl)butan-1-ol (2R,4a'R,5R,6'S,8'R,8a'R)-8'-(benzyloxy)-6'-((1S,3S)-1-(benzyloxy)-3-((2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl)butyl)-7'-methyleneoctahydro-3H,3'H-spiro[furan-2,2'-pyrano[3,2-b]pyran]-5-carbaldehyde (2S,5R,6S,8S)-5-Benzyloxy-8-[(R)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-10-methyl-1,7-dioxa-spiro[5.5]undec-10-ene-2-carbaldehyde (2R,3R,4R,4aR,6R,8aR)-4-(benzyloxy)-2-(((tert-butyldimethylsilyl)oxy)methyl)-6-methoxy-6-(3-((4-methoxybenzyl)oxy)propyl)octahydropyrano[3,2-b]pyran-3-ol (S)-1-{(2S,4R,4aR,6R,8aR)-4-Benzyloxy-6-methoxy-6-[3-(4-methoxy-benzyloxy)-propyl]-3-methylene-octahydro-pyrano[3,2-b]pyran-2-yl}-3-((2S,3R,6S)-3-methyl-1,7-dioxa-spiro[5.5]undec-2-yl)-butan-1-one (((2R,3S)-1-((4-methoxybenzyl)oxy)-2-methylhex-5-yn-3-yl)oxy)trimethylsilane (2S,5R)-5-[(2S,5R,6R,8S)-5-Benzyloxy-8-((R)-2-hydroxy-1-methyl-ethyl)-10-methyl-1,7-dioxa-spiro[5.5]undec-10-en-2-ylmethyl]-2-tert-butyl-5-methyl-[1,3]dioxolan-4-one (4S,9R,12S)-9-(benzyloxy)-4-((R)-1-((4-methoxybenzyl)oxy)propan-2-yl)-2,2,16,16-tetramethyl-15,15-diphenyl-12-((trimethylsilyl)oxy)-3,14-dioxa-2,15-disilaheptadec-6-yn-8-one (2R,3S)-1-[(4-methoxyphenyl)methoxy]-2-methylhex-5-yn-3-ol {(2S,5R,6S,8S)-5-Benzyloxy-8-[(R)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-10-methyl-1,7-dioxa-spiro[5.5]undec-10-en-2-ylmethoxy}-tert-butyl-diphenyl-silane tribenzyl okadaic acid (R)-1-((2R,3R,4R,5R,6R)-3-(benzyloxy)-5-hydroxy-6-(hydroxymethyl)-4-(methoxymethoxy)tetrahydro-2H-pyran-2-yl)-7-((tert-butyldiphenylsilyl)oxy)-6-hydroxyheptan-3-one ((2S,4R,4aR,6R,8aR)-4-(benzyloxy)-6-methoxy-6-(3-((4-methoxybenzyl)oxy)propyl)-3-methyleneoctahydropyrano[3,2-b]pyran-2-yl)methanol 1,2-O-(S)-pivalidene-7,24,27-tri-O-benzylokadaic acid (2R,3R,4R,4aR,6R,8aR)-4-(benzyloxy)-2-(hydroxymethyl)-6-methoxy-6-(3-((4-methoxybenzyl)oxy)propyl)octahydropyrano[3,2-b]pyran-3-ol (((2S,5R,6R)-5-(benzyloxy)-6-(phenylthio)tetrahydro-2H-pyran-2-yl)methoxy)(tert-butyl)diphenylsilane (2R,4a'R,5R,6'S,8'R,8a'S)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-6'-((1S,3S)-1-hydroxy-3-((2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl)butyl)-7'-methyleneoctahydro-3H,3'H-spiro[furan-2,2'-pyrano[3,2-b]pyran]-8'-ol 3-((4aR,6R,7R,8S,8aR)-7-Benzyloxy-8-methoxymethoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl)-propionaldehyde (2R,3R)-4-((4-methoxybenzyl)oxy)-3-methylbutane-1,2-diol (2R,3S)-1-(4-Methoxy-benzyloxy)-2-methyl-6-trimethylsilanyl-hex-5-yn-3-ol (S)-1-((2R,4a'R,5R,6'S,7'S,8'R,8a'R)-7'-(benzyloxy)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-8'-(methoxymethoxy)octahydro-3H,3'H-spiro[furan-2,2'-pyrano[3,2-b]pyran]-6'-yl)-3-((2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl)butan-1-one 3-((2R,4aR,6S,8R,8aR)-8-(benzyloxy)-6-((1S,3S)-1-(benzyloxy)-3-((2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl)butyl)-2-methoxy-7-methyleneoctahydropyrano[3,2-b]pyran-2-yl)propan-1-ol