化合物简介
Retosiban (GSK-221,149-A) is an oral drug which acts as a selective, sub-nanomolar (Ki = 0.65 nM) oxytocin receptor antagonist with >1400-fold selectivity over the related vasopressin receptors and is being developed by GlaxoSmithKline for the treatment of preterm labour.
基本信息
中文名称
(3R,6R)-6-[(2S)-butan-2-yl]-3-(2,3-dihydro-1H-inden-2-yl)-1-[(1R)-1-(2-methyl-1,3-oxazol-4-yl)-2-morpholin-4-yl-2-oxoethyl]piperazine-2,5-dione
英文名称
(3R,6R)-6-[(2S)-butan-2-yl]-3-(2,3-dihydro-1H-inden-2-yl)-1-[(1R)-1-(2-methyl-1,3-oxazol-4-yl)-2-morpholin-4-yl-2-oxoethyl]piperazine-2,5-dione
中文别名
英文别名
UNII-GIE06H28OX、Retosiban
CAS号
820957-38-8
分子式
C27H34N4O5
分子量
494.583
精确质量
494.253
PSA
108.47
LOGP
2.1913
编号系统
UNII
GIE06H28OX
合成路线
上游原料
共找到6个上游原料 >