N-(4-(6,7-二甲氧基喹啉-4-基氧基)苯基)-N-(4-氟苯基)环丙烷-1,1-二羧酰胺_CAS号:849217-68-1

化合物简介

Cabozantinib, marketed under the trade name Cabometyx among others, is a small molecule inhibitor of the tyrosine kinases c-Met and VEGFR2, and has been shown to reduce tumor growth, metastasis, and angiogenesis. It was discovered and developed by Exelixis Inc.

基本信息

中文名称

N-(4-(6,7-二甲氧基喹啉-4-基氧基)苯基)-N-(4-氟苯基)环丙烷-1,1-二羧酰胺

英文名称

cabozantinib

中文别名

博卡替尼、卡博替尼、N-[4-[(6,7-二甲氧基-4-喹啉基)氧基]苯基]-N\'-(4-氟苯基)-1,1-环丙烷二甲酰胺、卡赞替尼

英文别名

N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide、cyclopropane-1,1-dicarboxylic acid [4-(6,7-dimethoxy-quinoline-4-yloxy)-phenyl]-amide (4-fluoro-phenyl)-amide、[14C]-Cabozantinib、UNII-1C39JW444G、1-N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N\'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide、Cometriq、XL 184、Cabozantinib

CAS号

849217-68-1

分子式

C28H24FN3O5

分子量

501.506

精确质量

501.17

PSA

98.78

LOGP

5.6868