化合物简介
Cabozantinib is a small molecule C-Met modulator. Cabozantinib acts as a potent multitargeted VEGFR2, Met, FLT3, Tie2, Kit and Ret inhibitor with IC50 of 0.035, 1.8, 14.4, 14.3 and 4.6 nM for VEGFR2, Met, FLT3, Tie2 and Kit, respectively. Cabozantinib shows dose-dependent inhibition of tumor growth and tumor regression, associated with disruption of the tumor vasculature and extensive tumor cell apoptosis.
基本信息
中文名称
卡博替尼苹果酸盐
英文名称
Cabozantinib S-Malate
中文别名
苹果酸卡博替尼
英文别名
cyclopropane-1,1-dicarboxylic acid [4-(6,7-dimethoxyquinoline-4-yloxy)phenyl]amide (4-fluoro-phenyl)amide (L)-malate salt、Cabozantinib malate (XL184)、Cabozantinib malate、Cabozantinib malate salt、UNII-DR7ST46X58、cyclopropane-1,1-dicarboxylic acid [4-(6,7-dimethoxy-quinoline-4-yloxy)-phenyl]-amide (4-fluoro-phenyl)-amide L-malate、N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N\'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (L) malate、Cometriq、Cabozantinib s-malate [USAN]、XL 184、Cabozantinib L-Malate Salt、N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N\'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (L)-malate salt、Cabozantinib (XL184)、1-N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N\'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide,(2S)-2-hydroxybutanedioic acid
CAS号
1140909-48-3
分子式
C32H30FN3O10
分子量
635.593
精确质量
635.192
PSA
193.61
LOGP
4.5934
编号系统
UNII
DR7ST46X58
合成路线
