化合物简介
MDV 3100 is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. MDV 3100 has also been shown to induce tumor cell apoptosis, and has no agonist activity. MDV 3100 is a candidate for the treatment of castration-resistant prostate cancer.
基本信息
中文名称
4-[3-[4-氰基-3-(三氟甲基)苯基]-5,5-二甲基-4-氧代-2-硫酮-1-咪唑烷基]-2-氟-N-甲基苯甲酰胺
英文名称
enzalutamide
中文别名
恩扎鲁胺、4-(3-(4-氰基-3-(三氟甲基)苯基)-5,5-二甲基-4-氧代-2-硫氧代咪唑啉-1-基)-2-氟-N-甲基苯甲酰胺、恩杂鲁胺
英文别名
[14C]-Enzalutamide、N-methyl-4-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]-2-fluorobenzamide、4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide、Enzalutamide、MDV 3100、XTANDI、UNII-93T0T9GKNU、4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-sulfanylideneimidazolidin-1-yl]-2-fluoro-N-methylbenzamide
CAS号
915087-33-1
分子式
C21H16F4N4O2S
分子量
464.436
精确质量
464.093
PSA
108.53
LOGP
4.51338
编号系统
MDL号
MFCD14155804
物化性质
密度
1.49
折射率
1.629
安全信息
海关编码
2933990090
合成路线
