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匹罗卡品

匹罗卡品

CAS号：92-13-7

英文名：(+)-pilocarpine

分子式

C11H16N2O2

熔点

密度

1.22 g/cm3

分子量

208.257

沸点

260ºC at 5 MM HG (PARTIALºCONVERSION TO ISOPILºCARPINE)

溶解度

信号词

危险品标志

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化合物简介

Pilocarpine is a drug used to treat dry mouth and glaucoma. It is a parasympathomimetic alkaloid obtained from the leaves of tropical South American shrubs from the genus Pilocarpus. It is a non-selective muscarinic receptor agonist in the parasympathetic nervous system, which acts therapeutically at the muscarinic acetylcholine receptor M3 due to its topical application, e.g., in glaucoma and xerostomia.

基本信息

中文名称

匹罗卡品

英文名称

(+)-pilocarpine

中文别名

毛果云香碱、毛果芸香碱

英文别名

ocusertp20、PILOCARPINE、2(3H)-Furanone, 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, (3S-cis)-、pilokarpol、Pilocarpol、Ocucarpine、Ocusert、actone、Syncarpine、Pilokarpin、Pilocarpin

CAS号

92-13-7

分子式

C11H16N2O2

分子量

208.257

精确质量

208.121

PSA

44.12

LOGP

1.1618

编号系统

UNII

01MI4Q9DI3

物化性质

密度

1.22 g/cm3

沸点

260ºC at 5 MM HG (PARTIALºCONVERSION TO ISOPILºCARPINE)

闪点

215ºC

安全信息

安全说明

S25; S45

危险类别码

R26/28

危险品运输编码

UN 1544

危险类别

6.1(b)

包装等级

III

危险品标志

T+

合成路线

共找到3条合成路线 >

3-ethyl-dihydro-4-[(1-methyl-1H-2-mercaptoimidazol-5-yl)methyl]-2(3H)-furanone

3-ethyl-dihydro-4-[(1-methyl-1H-2-mercaptoimidazol-5-yl)methyl]-2(3H)-furanone

匹罗卡品

上游原料

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(2S,3R)-2-Ethyl-3-hydroxymethyl-4-(3-methyl-3H-imidazol-4-yl)-butyric acid 4-tert-butyl-benzyl ester

(2S,3R)-2-Ethyl-3-hydroxymethyl-4-(3-methyl-3H-imidazol-4-yl)-butyric acid 4-tert-butyl-benzyl ester

α-乙酰基-γ-丁内酯

α-乙酰基-γ-丁内酯

3-acetyl-3-phenylselenyl-3H-dihydrofuran-2-one

3-acetyl-3-phenylselenyl-3H-dihydrofuran-2-one

(3S)-3r-acetyl-4t-(3-methyl-3H-imidazol-4-ylmethyl)-dihydro-furan-2-one

(3S)-3r-acetyl-4t-(3-methyl-3H-imidazol-4-ylmethyl)-dihydro-furan-2-one

(S)-4-Ethyl-2-(3-methyl-3H-imidazol-4-yl)-5-oxo-tetrahydro-furan-3-carbonyl chloride

(S)-4-Ethyl-2-(3-methyl-3H-imidazol-4-yl)-5-oxo-tetrahydro-furan-3-carbonyl chloride

pilocarpic acid 4-methylbenzyl ester

pilocarpic acid 4-methylbenzyl ester

下游产品

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1,5-二甲基-1H-咪唑

1,5-二甲基-1H-咪唑

匹罗卡品

上游原料

(2S,3R)-2-Ethyl-3-hydroxymethyl-4-(3-methyl-3H-imidazol-4-yl)-butyric acid 4-tert-butyl-benzyl ester α-乙酰基-γ-丁内酯 3-acetyl-3-phenylselenyl-3H-dihydrofuran-2-one (3S)-3r-acetyl-4t-(3-methyl-3H-imidazol-4-ylmethyl)-dihydro-furan-2-one (S)-4-Ethyl-2-(3-methyl-3H-imidazol-4-yl)-5-oxo-tetrahydro-furan-3-carbonyl chloride pilocarpic acid 4-methylbenzyl ester 甲基碘 (3aS,4R,7S,7aR)-7a-acetyl-3a,4,7,7a-tetrahydro-4,7-methanoisobenzofuran-1(3H)-one dimethyl (S)-N-(9-phenyl-9H-fluoren-9-yl)aspartate 2-methylbenzyl (2S,3R)-2-ethyl-4-hydroxy-3-((1-methyl-1H-imidazol-5-yl)methyl)butanoate 4-acetyl-2H-furan-5-one (2S,3S)-dimethyl 2-N-(9-phenylfluorenyl)-3-ethyl-L-aspartate (3S)-3r-benzoyl-4t-(3-methyl-3H-imidazol-4-ylmethyl)-dihydro-furan-2-one (R)-3-ethylidene-4-[(1-methylimidazol-5-yl)methyl]tetrahydrofuran-2-one (+)-pilosinine 1-甲基-1氢-5-醛基-咪唑甲胺 (3S,4R)-3-乙基-4-(3H-咪唑-4-基甲基)四氢呋喃-2-酮匹罗卡品 4-chlorobenzyl (2S,3R)-2-ethyl-4-hydroxy-3-((1-methyl-1H-imidazol-5-yl)methyl)butanoate phenethyl (2S,3R)-2-ethyl-4-hydroxy-3-((1-methyl-1H-imidazol-5-yl)methyl)butanoate (2S,3R)-2-Ethyl-3-hydroxymethyl-4-(3-methyl-3H-imidazol-4-yl)-butyric acid 1-phenyl-ethyl ester (2S,3R)-2-Ethyl-3-hydroxymethyl-4-(3-methyl-3H-imidazol-4-yl)-butyric acid benzyl ester 3-ethyl-dihydro-4-[(1-methyl-1H-2-mercaptoimidazol-5-yl)methyl]-2(3H)-furanone 4-toluene-sulfonylmethyl isocyanide (3aS,4R,7S,7aR)-7a-acetyl-3a,4,7,7a-tetrahydro-4,7-methanoisobenzofuran-1(3H)-one (3S)-cis-3-ethyl-4-(3-methyl-2-thioxo-2,3-dihydro-1H-imidazol-4-ylmethyl)-dihydro-furan-2-one (2S,3S)-2-bromo-3-ethylbutane-1,4-dioic acid 1-tert-butyl 4-methyl diester 异毛果芸香素 (2S,3R)-2-溴-3-(甲氧羰基)戊酸 ethyl (2S,3R)-2-ethyl-4-hydroxy-3-((1-methyl-1H-imidazol-5-yl)methyl)butanoate 3-((1S)-1-hydroxyethyl)-2(5H)-furanone (4R)-(Z)-dehydrohomopilopic aldehyde (4-乙基-5-氧代四氢呋喃-3-基)-乙醛 (2S,3R)-2-Ethyl-3-hydroxymethyl-4-(3-methyl-3H-imidazol-4-yl)-butyric acid hexyl ester

下游产品

丁酸 1,5-二甲基-1H-咪唑匹罗卡品甲胺