2-氨基噻唑

2-氨基噻唑

CAS号:96-50-4
英文名:1,3-thiazol-2-amine
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化合物简介
2-Aminothiazole is a heterocyclic amine featuring an thiazole core. It can also be considered a cyclic isothiourea. It possesses an odor similar to pyridine and is soluble in water, alcohols and diethyl ether. It is commonly used as a starting point for the synthesis of many compounds including sulfur drugs, biocides, fungicides, dyes and chemical reaction accelerators. 2-Aminothiazole can be used as a thyroid inhibitor in the treatment of hyperthyroidism and has antibacterial activity. Alternatively, its acid tartrate salt can be used. Recent studies using prion-infected neuroblastoma cell lines have suggested that aminothiazole may be used as a therapeutic drug for prion diseases.
基本信息
编号系统
物化性质
安全信息
生产方法及用途
生产方法
由硫脲与氯乙醛(或乙醇和氯气,或α,β二氯乙基乙醚)经环合而得。在反应器中加入热水、硫脲和α,β-二氯乙基乙醚。在搅拌下回流2h。冷却,经滴液漏斗加入氢氧化钠溶液,使溶液呈碱性,析出2-氨基噻唑晶体。然后加入乙醚使之溶解。分出醚层,用水洗涤后,以无水硫酸钠干燥,蒸出乙醚得粗品。用乙醇重结晶,得黄色晶体。产率为80%,熔点90℃。
用途
2-氨基噻唑主要用于合成硝基磺胺噻唑(Nitrosulfathiazole)、磺胺噻唑(Sulfathiazole)、琥磺噻唑(Sulfasuxidinum)、马来酰磺胺噻唑(Carbothiazol)、酞磺胺噻唑(Phthalylsulfathiazole)、克泻磺(Oxyquinoline),还用作染料中间体。
国家/地区名称
海关编码
更新时间
操作
中国29341000902019-03查看
美国29341090002019-03查看
印度293410002019-03查看
欧盟293410002019-03查看
英国29341000902019-03查看
日本2934100002019-03查看
韩国29341010002019-03查看
加拿大29341000002019-03查看
下游产品
2-氰基-N-噻唑-2-乙酰胺 4,5,6,7-tetraiodo-2-(1,3-thiazol-2-yl)isoindole-1,3-dione 1,1-diethyl-3-(1,3-thiazol-2-yl)thiourea 1-methyl-3-(1,3-thiazol-2-yl)thiourea 4,5,6,7-tetrabromo-2-(1,3-thiazol-2-yl)isoindole-1,3-dione 6-chloro-7-(chloromethyl)-[1,3]thiazolo[3,2-a]pyrimidin-5-one 5-甲基-4-(2-噻唑偶氮)雷琐辛 乙二肟 3-环戊基-2-[4-(甲烷磺酰基)苯基]-N-(噻唑-2-基)丙胺 3,3-dimethyl-5-oxo-5-(1,3-thiazol-2-ylamino)pentanoic acid Phenol, o-(N-2-thiazolylformimidoyl)- 噻吩-2,3-二羧酸 苯基-3-(2-噻唑基)-2-硫脲 N-[4,6-bis(trichloromethyl)-1,3,5-triazin-2-yl]-1,3-thiazol-2-amine 1-phenyl-3-(1,3-thiazol-2-yl)urea 2-(2-氯乙酰胺基)噻唑 5-叔丁基噻唑-2-胺 咪唑[2,1-b]噻唑-6-甲酸 2-溴-5-硝基噻唑 噻唑 2-氨基-5-溴噻唑 3a,7a-dimethyl-2-(1,3-thiazol-2-yl)-4,5,6,7-tetrahydro-octahydro-1H-4,7-epoxyisoindole-1,3-dione 2-溴-n-1,3-噻唑-2-基乙酰胺 噻唑-2-硫脲 舒多昔康 2,3,4,5-tetrabromo-6-(1,3-thiazol-2-ylcarbamoyl)benzoic acid 6-(4-溴苯基)咪唑[2,1-b-1,3]噻唑 4,7-dimethyl-2-(1,3-thiazol-2-yl)-3a,5,6,7a-tetrahydro-octahydro-1H-4,7-epoxyisoindole-1,3-dione 4-氯-N-(1,3-噻唑)丁酰胺 3-oxo-4-(1,3-thiazol-2-ylhydrazinylidene)naphthalene-2,7-disulfonic acid 2-乙酰胺基噻唑 7-(氯甲基)-5H-[1,3]噻唑并[3,2-a]嘧啶-5-酮 1-methyl-3-(1,3-thiazol-2-yl)urea 5-hydroxy-4-oxo-3-(1,3-thiazol-2-ylhydrazinylidene)naphthalene-2,7-disulfonic acid 1-(6-甲基咪唑并[2,1-b][1,3]噻唑-5-基)乙酮 2-碘噻唑 4-Chloro-α-(1-methylethyl)-N-2-thiazolyl-benzeneacetamide 2-溴噻唑 2-氯噻唑 5-氯-2-氨基噻唑 6-甲基咪唑[2,1-B]噻唑-5-羧酸乙酯 (2-亚氨基-3-噻唑)-乙酸 3-hydroxy-4-nitroso-2,7-Naphthalenedisulfonic acid 乙基咪唑[2,1-b]噻唑-6-羧酸 N-噻唑-2-基琥珀酰胺酸 氨基甲酸叔丁酯 3-(1,3-thiazol-2-ylamino)indol-2-one 2-(1,3-thiazol-2-ylcarbamoyl)cyclohexane-1-carboxylic acid