百科

罗非昔布

罗非昔布

CAS号：162011-90-7

英文名：rofecoxib

分子式：C17H14O4S

分子量：314.356

合成路线

3-(4-methylsulfanylphenyl)-4-phenyl-2H-furan-5-one

3-(4-methylsulfanylphenyl)-4-phenyl-2H-furan-5-one

罗非昔布

[2-(4-methylsulfonylphenyl)-2-oxoethyl] 2-phenylacetate

[2-(4-methylsulfonylphenyl)-2-oxoethyl] 2-phenylacetate

罗非昔布

苯乙酸

溴乙酸乙酯

溴乙酸乙酯

罗非昔布

3-chloro-4-(4'-methylsulfonylphenyl)-5H-furan-2-one

3-chloro-4-(4'-methylsulfonylphenyl)-5H-furan-2-one

苯硼酸

罗非昔布

苯乙酸

三乙胺

2-溴-1-(4-甲磺酰基)苯乙酮

2-溴-1-(4-甲磺酰基)苯乙酮

罗非昔布

2-溴-1-(4-甲磺酰基)苯乙酮

2-溴-1-(4-甲磺酰基)苯乙酮

2-(diethoxyphosphino)-2-phenylacetic acid

2-(diethoxyphosphino)-2-phenylacetic acid

罗非昔布

4-bromo-3-(4-methylsulfanylphenyl)-2H-furan-5-one

4-bromo-3-(4-methylsulfanylphenyl)-2H-furan-5-one

罗非昔布

苯乙酸

三乙胺

2-溴-1-(4-甲磺酰基)苯乙酮

2-溴-1-(4-甲磺酰基)苯乙酮

罗非昔布

4-甲硫基苯硼酸

4-甲硫基苯硼酸

罗非昔布

2(5H)-Furanone, 3-chloro-4-[4-(methylthio)phenyl]-

2(5H)-Furanone, 3-chloro-4-[4-(methylthio)phenyl]-

罗非昔布

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上游原料

三丁基苯基锡 4'-甲硫基苯乙酮 4-bromo-3-(4-methylsulfanylphenyl)-2H-furan-5-one 茴香硫醚水苯硼酸三乙胺 2-(diethoxyphosphino)-2-phenylacetic acid 2-溴-1-(4-甲磺酰基)苯乙酮 [2-(4-methylsulfonylphenyl)-2-oxoethyl] 2-phenylacetate 3-chloro-4-(4'-methylsulfonylphenyl)-5H-furan-2-one 4-甲砜基苯乙酮苯乙酸溴乙酸乙酯 4-甲硫基苯硼酸 3-苯基-2-丙炔-1-醇 3-(4-methylsulfanylphenyl)-4-phenyl-2H-furan-5-one

下游产品

2-(4-methylsulfonylphenyl)-3-phenylbut-2-ene-1,4-diol 5-羟基万络