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(3S,4a,8aS)-2-[(2R,3S)-3-氨基-2-羟基-4-苯基丁基]-N-叔丁基十氢异喹啉-3-甲酰胺

(3S,4a,8aS)-2-[(2R,3S)-3-氨基-2-羟基-4-苯基丁基]-N-叔丁基十氢异喹啉-3-甲酰胺

CAS号：136522-17-3

英文名：(3S,4aS,8aS)-2-[(3S)-3-amino-2-hydroxy-4-phenylbutyl]-N-tert-butyl-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxamide

分子式

C24H39N3O2

熔点

密度

1.078

分子量

401.585

沸点

溶解度

信号词

危险品标志

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化合物简介

(3S,4aS,8aS)- 2-[(2R,3S)-3-Amino-2-hydroxy-4-phenylbutyl]-N-(1,1-dimethylethyl)decahydro-3-isoquinolinecarboxamide is an intermediate in the synthesis of Saquinavir.

基本信息

中文名称

(3S,4a,8aS)-2-[(2R,3S)-3-氨基-2-羟基-4-苯基丁基]-N-叔丁基十氢异喹啉-3-甲酰胺

英文名称

(3S,4aS,8aS)-2-[(3S)-3-amino-2-hydroxy-4-phenylbutyl]-N-tert-butyl-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxamide

中文别名

[3S-[2(2S*,3R),3A,4AB,8AB]]-2-(3-氨基-2-羟基-4-苯丁基)-N-(1,1-二甲基乙基)十氢喹啉-3-甲酰胺

英文别名

2-(3-amino-2-hydroxy-4-phenylbutyl)decahydroisoquinoline-3-carboxylic acid tert-butylamide、2-(3(S)-Amino-2(R)-hydroxy-4-phenylbutyl)-N-tert-butyldecahydro-(4aS,8aS)-isoquinoline-3(S)-carboxamide、N-tert-butyl-2-(2(R)-hydroxy-4-phenyl-3(S)-aminobutyl)decahydro(4aS,8aS)-isoquinoline-3(S)-carboxamide、(3S,4aS,8aS)-2-[(2R,3S)-3-Amino-2-hydroxy-4-phenylbutyl]-N-(1,1-dimethylethyl)decahydro-3-isoquinolinecarboxamide、[3S-[2(2S*,3R*),3|A,4a|A,8a|A]]-2-(3-Amino-2-hydroxy-4-phenylbutyl)-N-(1,1-dimethylethyl)decahydro-3-isoquinolinecarboxamide、cis-N-butyldecahydro-2-<2(R)-hydroxy-4-phenyl-3(S)-aminobutyl>-(4aS,8aS)-isoquinoline-3(S)-carboxamide、[3S,4aS,8aS]-2-(3S-amino-2R-hydroxy-4-phenylbutyl)-N-(1,1-dimethylethyl)-decahydro-3-isoquinoline carboxamide

CAS号

136522-17-3

分子式

C24H39N3O2

分子量

401.585

精确质量

401.304

PSA

78.59

LOGP

3.7418

物化性质

密度

1.078

安全信息

危险品标志

Xn

合成路线

共找到6条合成路线 >

N-tert-butyl-2-[2(R)-hydroxy-4-phenyl-3(S)-azidobutyl]decahydro(4aS,8aS)-isoquinoline-3(S)-carboxamide

N-tert-butyl-2-[2(R)-hydroxy-4-phenyl-3(S)-azidobutyl]decahydro(4aS,8aS)-isoquinoline-3(S)-carboxamide

(3S,4a,8aS)-2-[(2R,3S)-3-氨基-2-羟基-4-苯基丁基]-N-叔丁基十氢异喹啉-3-甲酰胺

(3S,4a,8aS)-2-[(2R,3S)-3-氨基-2-羟基-4-苯基丁基]-N-叔丁基十氢异喹啉-3-甲酰胺

上游原料

共找到58个上游原料 >

(2S,3S)-1-bromo-3-((tert-butoxycarbonyl)amino)-4-phenyl-2-butanol

(2S,3S)-1-bromo-3-((tert-butoxycarbonyl)amino)-4-phenyl-2-butanol

(S)-2-(1,3-dioxoisoindolin-2-yl)-3-phenylpropanoyl chloride

(S)-2-(1,3-dioxoisoindolin-2-yl)-3-phenylpropanoyl chloride

BOC-L-苯丙氨酸

BOC-L-苯丙氨酸

[3S-(3α,4αβ,8αβ)]-N-(tert-butyl)decahydro-3-isoquinolinecarboxamide

[3S-(3α,4αβ,8αβ)]-N-(tert-butyl)decahydro-3-isoquinolinecarboxamide

[(1S,2R)-1-Benzyl-3-((3S,4aS,8aS)-3-tert-butylcarbamoyl-octahydro-isoquinolin-2-yl)-2-hydroxy-propyl]-carbamic acid methyl ester

[(1S,2R)-1-Benzyl-3-((3S,4aS,8aS)-3-tert-butylcarbamoyl-octahydro-isoquinolin-2-yl)-2-hydroxy-propyl]-carbamic acid methyl ester

(4S,5S)-4-benzyl-5-(bromomethyl)-3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidine

(4S,5S)-4-benzyl-5-(bromomethyl)-3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidine

下游产品

共找到3个下游商品 >

(3S,4aS,8aS)-N-tert-butyl-2-[(2R,3S)-2-hydroxy-3-[[(2S)-2-(methanesulfonamido)-3-naphthalen-2-ylsulfanylpropanoyl]amino]-4-phenylbutyl]-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxamide

(3S,4aS,8aS)-N-tert-butyl-2-[(2R,3S)-2-hydroxy-3-[[(2S)-2-(methanesulfonamido)-3-naphthalen-2-ylsulfanylpropanoyl]amino]-4-phenylbutyl]-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxamide

benzyl N-[(2S)-1-[[(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1-phenylbutan-2-yl]amino]-4-amino-1,4-dioxobutan-2-yl]carbamate

benzyl N-[(2S)-1-[[(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1-phenylbutan-2-yl]amino]-4-amino-1,4-dioxobutan-2-yl]carbamate

沙喹那韦

上游原料

(2S,3S)-1-bromo-3-((tert-butoxycarbonyl)amino)-4-phenyl-2-butanol (S)-2-(1,3-dioxoisoindolin-2-yl)-3-phenylpropanoyl chloride BOC-L-苯丙氨酸 [3S-(3α,4αβ,8αβ)]-N-(tert-butyl)decahydro-3-isoquinolinecarboxamide [(1S,2R)-1-Benzyl-3-((3S,4aS,8aS)-3-tert-butylcarbamoyl-octahydro-isoquinolin-2-yl)-2-hydroxy-propyl]-carbamic acid methyl ester (4S,5S)-4-benzyl-5-(bromomethyl)-3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidine N-苄氧羰基-L-苯丙氨酸 N-tert-Butyldecahydro-2-(2(R)-hydroxy-4-phenyl-3(S)phthalimidobutyl)-(4aS,8aS)-isoquinoline-3(S)-carboxamide (2S,3S)-1,2-环氧-3-苄氧羰基氨基-4-苯基丁烷 4(S)-(1(S)-Azido-2-phenylethyl)-1,3,2-dioxathiolane 2,2-dioxide ethyl (S)-4-benzyloxycarbonylamino-3-oxo-5-phenylpentanoate N-Boc-L-苯丙氨醛 (S)-N-叔丁基-1,2,3,4-四氢异喹啉-3-甲酰胺 (2R,2S)-(3S)-1,2-epoxy-3-phenylmethoxycarbonylamino-4-phenylbutane 2(S)-[2-phenyl-1(S)-phthalimidoethyl]oxirane 3(S)-(tert-Butoxyformamido)-2(S)-hydroxy-4-phenyl-1-butanal 1-Hydroxy-4-phenyl-3(S)-phthalimido-2-butanone (1S,2S)-2-((tert-butoxycarbonyl)amino)-3-phenyl-1-(thiazol-2-yl)propyl acetate 4(S)-Benzyl-3-(tert-butoxycarbonyl)-2,2-dimethyl-5(R)-oxazolidineacetic acid Ethyl 4(S)-benzyl-3-(tert-butoxycarbonyl)-2,2-dimethyl-5(R)-oxazolidineacetate (S)-2-甲氧酰胺基-3-苯丙酸甲酯 (2S,3S)-2-azido-1-phenyl-butane-3,4-diol 4(S)-Benzyl-3-(tert-butoxycarbonyl)-2,2-dimethyl-5(R)-oxazolidineacetic acid chloride 2-[(S)-1-Benzyl-2-oxo-3-(tetrahydro-pyran-2-yloxy)-propyl]-isoindole-1,3-dione N-Boc-β-keto-γ-phenylalanine 2-(2(S)-(tert-Butoxyformamido)-1-hydroxy-3-phenylpropyl)thiazole N-tert-butyl-2-[2(R)-hydroxy-4-phenyl-3(S)-azidobutyl]decahydro(4aS,8aS)-isoquinoline-3(S)-carboxamide L-苯丙氨酸甲酯 Methanesulfonic acid (1R,2S)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-phenyl-1-(tetrahydro-pyran-2-yloxymethyl)-propyl ester (S,S)-2-(2-(N-(tert-Butoxycarbonyl)amino)-1-hydroxy-3-phenylpropyl)-1,3-thiazole (1S)-1-(2R)-环氧乙基-2-苯乙基氨基甲酸叔丁酯 4(S)-Benzyl-3-(benzyloxycarbonyl)-2,2-dimethyl-5(R)-oxazolidineacetic acid chloride benzyl 3(S)-(t-butylcarbamoyl)-1,2,3,4-tetrahydro-2-isoquinolinecarboxylate Ethyl 4(S)-benzyl-3-(benzyloxycarbonyl)-2,2-dimethyl-5(R)-oxazolidineacetate Ethyl 4(S)-(benzyloxyformamido)-3(R)-hydroxy-5-phenylpentanoate L-苯丙氨酸 3(S)-(Benzyloxyformamido)-1-bromo-4-phenyl-2(S)-butanol 2(R)-(Methanesulfonyloxy)-4-phenyl-3(S)-phthalimido-1-butanol 4(S)-Benzyl-3-(benzyloxycarbonyl)-2,2-dimethyl-5(R)-oxazolidineacetic acid N-邻苯二甲酰基-L-苯丙氨酸 3,4-二氢一异喹啉-2,3-二甲酸-2-苄酯 N-(tert-butoxycarbonyl)-4(S)-amino-3(R)-hydroxy-5-phenylpentanoic acid ethyl ester (2S)-2-[1'(S)-1-azido-2-phenylethyl]oxirane 甲基[(2S,3S)-4-氯-3-羟基-1-苯基-2-丁烷基]氨基甲酸酯 (S)-(-)-1,2,3,4-四氢异喹啉-3-羧酸 (3S,4aS,8aS)- (S)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl chloride 2-[2(R)-hydroxy-4-phenyl-3(S)-[[N-(phenylmethoxy)carbonyl]amino]butyl]-N-tert-butyldecahydro-(4aS,8aS)-isoquinoline-3(S)-carboxamide

下游产品

(3S,4aS,8aS)-N-tert-butyl-2-[(2R,3S)-2-hydroxy-3-[[(2S)-2-(methanesulfonamido)-3-naphthalen-2-ylsulfanylpropanoyl]amino]-4-phenylbutyl]-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxamide benzyl N-[(2S)-1-[[(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1-phenylbutan-2-yl]amino]-4-amino-1,4-dioxobutan-2-yl]carbamate 沙喹那韦