决奈达隆

决奈达隆

CAS号:141626-36-0
英文名:dronedarone
若想填写更详细的询价信息,请点击进入询价页面
点我
化合物简介
Dronedarone (development codename SR33589 and marketed as Multaq) is a drug by Sanofi-Aventis, mainly for the indication of cardiac arrhythmias. It was approved by the FDA on July 2, 2009. It was recommended as an alternative to amiodarone for the treatment of atrial fibrillation and atrial flutter in people whose hearts have either returned to normal rhythm or who undergo drug therapy or electric shock treatment i.e. direct current cardioversion (DCCV) to maintain normal rhythm. It is a class III antiarrhythmic drug. In the United States, the FDA approved label includes a claim for reducing hospitalization, but not for reducing mortality, as a reduction in mortality was not demonstrated in the clinical development program. A trial of the drug in heart failure was stopped as an interim analysis showed a possible increase in heart failure deaths, in patients with moderate to severe CHF.
基本信息
编号系统
物化性质
安全信息
上游原料
N-[2-butyl-3-{4-[(3-amino)propoxy]benzoyl}-1-benzofuran-5-yl]-methansulfonamide 2-butyl-5-(methanesulfonamido)benzofuran-3-carbonyl chloride 正溴丁烷 丁酸 2-n-butyl-3-{4-[3-(di-n-butylamino)-propoxyl]-benzoyl}-5-bromo-benzofuran N-(2-butyl-3-{4-[3-(dibutylamino)-2-hydroxypropoxy]benzoyl}-1-benzofuran-5-yl)methanesulfonamide 3-(二丁基氨基)-1-丙醇 4-({2-butyl-5-[(methylsulfonyl)amino]-1-benzofuran-3-yl}carbonyl)phenyl-4-chlorobenzenesulfonate N-[2-butyl-3-(4-bromobenzoyl)-1-benzofuran-5-yl]methanesulfonamide 4-(3-(dibutylamino)propoxy)phenylboronic acid 4-({2-butyl-5-[(methylsulfonyl)amino]-1-benzofuran-3-yl}carbonyl)phenyl-4-methylbenzenesulfonate (E)-1-(4-(3-(dibutylamino)propoxy)phenyl)-3-(dimethylamino)hept-2-en-1-one dronedarone mesylate 甲烷磺酰氯 2-butyl-3-({4-[3-(dibutylamino)propoxy]phenyl}carbonyl)-1-benzofuran-5-yl trifluoromethanesulfonate N-(2-butyl-3-(4-(3-hydroxypropoxy)benzoyl)benzofuran-5-yl)methanesulfonamide N-(3-(4-(3-bromopropoxy)benzoyl)-2-butylbenzofuran-5-yl)methanesulfonamide 5-amino 3-[4-(3-di-n-butylamino-propoxy)benzoyl] 2-n-butyl benzofuran N-[2-n-butyl-3-[4-[3 (-di-n-butylamino)propoxy]benzoyl]-1-benzofuran-5 -yl]-N'-ethoxycarbonyl-methanesulfonamide 正丁醛 3-dibutylamino-1-propanol sodium salt N-(3-phenoxypropyl)-N-butylbutan-1-amine N-[2-butyl-3-(4-iodobenzoyl)-1-benzofuran-5-yl]methanesulfonamide (5-氨基-2-丁基-3-苯并呋喃基)[4-[3-(二丁基氨基)丙氧基]苯基]甲酮 甲基磺酰胺 N-(3-(4-bromophenoxy)propyl)-N-butylbutan-1-amine 对甲苯磺酸正丁酯 2-butyl-5-(methanesulfonamido)benzofuran-3-carboxylic acid 4-({2-butyl-5-[(methylsulfonyl)amino]-1-benzofuran-3-yl}carbonyl)phenyl-4-[(methylsulfonyl)amino]benzenesulfonate 3-dibutylamino-1-propanol potassium salt 4-({2-butyl-5-[(methylsulfonyl)amino]-1-benzofuran-3-yl}carbonyl)phenyltrifluoromethanesulfonate (E/Z)-1-(4-(3-(dibutylamino)propoxy)phenyl)-3-(trimethylsilyloxy)hept-2-en-1-one 3-(4-(2-butyl-5-(methylsulfonamido)benzofuran-3-carbonyl)phenoxy)propyl 4-methylbenzenesulfonate (2-butyl-5-methylsulfanylamino-benzofuran-3-yl)-[4-(3-dibutylamino-propoxy)-phenyl]-methanone 3-{4-[(2-butyl-5-methanesulfonamide-1-benzofuran-3-yl)carbonyl]phenoxy}propyl methanesulfonate 1-{4-[3-(di-n-butylamino)propoxy]phenyl}-1,3-heptanedione 二正丁胺 甲烷磺酸 N-(4-oxocyclohexa-2,5-dien-1-ylidene)methanesulfonamide N-[2-n-butyl-3-[4-[3-(di-n-butylamino)propoxy]benzoyl]-1-benzofuran-5-yl]-N'-benzoyl-methanesulfonamide N-[2-butyl-3-(4-fluorobenzoyl)-1-benzofuran-5-yl]methanesulfonamide N-[2-n-butyl-3-[4-[3 (-di-n-butylamino)propoxy]benzoyl]-1-benzofuran-5-yl]-N'-acetyl-methanesulfonamide N-[2-butyl-3-(4-chlorobenzoyl)-1-benzofuran-5-yl]methanesulfonamide 甲基磺酸酐