首页
1,2-二甲基-3-羟基-4-吡啶酮

1,2-二甲基-3-羟基-4-吡啶酮

CAS号:30652-11-0
英文名:deferiprone
若想填写更详细的询价信息,请点击进入询价页面
点我
化合物简介
Deferiprone (tradenames include Ferriprox) is a drug that chelates iron and is used to treat iron overload in thalassaemia major. It was first approved for use in treating thalassaemia major in 1994 and had been licensed for use in Europe and Asia for many years while awaiting approval in Canada and the United States. On October 14, 2011, it was approved for use in the US under the FDA’s accelerated approval program.
基本信息
编号系统
物化性质
安全信息
生产方法及用途
生产方法
以 3-羟基-2-甲基-
4 -吡啶酮为原料 ,经羟基保护、N-甲基化和脱保护基反应得到去铁剂去铁酮 ,总收率 4 9%。
用途
是一个与铁以3:1摩尔比键合的二齿配位体。去铁酮片用于治疗耐受或不愿意接受现有螯合剂治疗的铁负荷过多的地中海贫血患者。