2′,3′-二脱氧胸苷

2′,3′-二脱氧胸苷

CAS号:3416-05-5
英文名:1-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
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基本信息
编号系统
物化性质
安全信息
生产方法及用途
用途
滴滴涕曾在全世界范围内广泛使用,在发展农业林业和保障人体健康等方面,都发挥过重大作用。70年代以前主要用于防治棉花后期害虫、森林害虫以及卫生害虫等。对蚜、螨、蚧等毒杀作用不大。由于长期大量使用,导致大部分害虫对其产生抗药性。同时由于其稳定性太强,可在环境中长期残留,污染环境和食品引起积累性毒性。不少国家在60年代后期就限制或禁止使用,中国1983年宣布停止生产和使用。
上游原料
2,4-二氯-5-甲基嘧啶 2-chloro-5-methyl-4-(2 -trimethylsilanylethoxy)pyrimidine 2-Furancarboxylic acid, 2,5-dihydro-2,5-dimethoxy-, ethyl ester 1-[5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-β-D-glycero-pentofuranosyl]thymine 5-(羟基甲基)二氢-2(3H)-呋喃酮 (S)-5-羟甲基二氢呋喃-2-酮 3',5'-二-O-甲磺酰基胸苷 1-[5-O-(tert-butyldimethylsilyl)-2,3-dideoxy-β-D-erythro-pentofuranosyl]thymine 甲基2,5-二氢-2,5-二甲氧基-2-呋喃羧酸 1-[5-O-(tert-butyldimethylsilyl)-2-deoxy-3-O-[(1-imidazolyl)thiocarbonyl]-β-D-erythro-pentofuranosyl]thymine 2-Chloro-4-methoxy-5-methylpyrimidine 1-((2R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(phenylselanyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione 1'-[5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxy-D-glycero-pentofuranosyl]thymine (S)-(-)-Tetrahydro-5-oxo-2-furancarboxaldehyde (2S,5R)-5-(5-Methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-carboxylic acid methyl ester 1-[2',3'-dideoxy-3'(R)-phenylseleno-β-D-glycero-pentofuranosyl]thymine 5'-O-[(1,1-Dimethylethyl)-dimethylsilyl]-3'-O-(phenoxythioxomethyl)thymidine 5-O-(tert-butyldiphenylsilyl)-3-deoxy-2-Se-phenyl-2-seleno-D-erythro-pentonic acid γ-lactone 5’-O-(叔丁基二甲基甲硅烷基)胸苷 5-O-(4,4-二甲氧基三苯甲游基)-2,3-脱水胸腺嘧啶脱氧核苷 1-(2,5-dihydro-5-methoxy-5-methoxycarbonyl-furan-2-yl)thymine 1-(5-O-(tert-butyldiphenylsilyl)-3-deoxy-2-Se-phenyl-2-seleno-β-D-erythro-pentofuranosyl)thymine 5’-O-三苯甲基胸苷 2,3-dideoxy-L-arabino-heptono-1,4-lactone (S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-trimethylsilanyloxy-2,3-dihydro-furan 3',5'-bis-O-(phenoxythiocarbonyl)thymidine methyl 5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)furan-2-carboxylate 司他夫定 ((S)-5-Phenylselanyl-tetrahydro-furan-2-yl)-methanol (5S)-(5-tert-butyldimethylsilyloxymethyl)furan-2(5H)-one tert-butyl(((2S)-5-methoxytetrahydrofuran-2-yl)methoxy)dimethylsilane 三甲基硅烷化重氮甲烷 1-((2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-methoxy-5-methylpyrimidin-2(1H)-one [(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl acetate 1-O-acetyl-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2-(phenylselenenyl)-D-erythro-pentafuranose [(2R,3S,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl] methanesulfonate 5-甲基脲嘧啶 2-糠酸乙酯 1-(5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-α,β-D-glycero-pentofuranosyl)thymine 1-(2,3-dideoxy-3-C-selenophenyl-β-D-erythro-pentofuranosyl)thymine 3'-deoxy-5'-O-(phenoxythiocarbonyl)thymidine 5-O-(tert-butyldiphenylsilyl)-3-deoxy-2-Se-phenyl-2-seleno-D-threo-pentonic acid γ-lactone 5'-O-(4,4'-dimethoxytrityl)-3'-mesyl-2',3'-dideoxythymidine 3'-deoxy-5'-O-triphenylmethylthymidine 5-氟-2-硝基苯甲酸 O,O′-二(三甲基甲硅烷基)胸苷 胸苷