胸苷

CAS号：50-89-5

英文名：thymidine

分子式

C10H14N2O5

熔点

187-189ºC

密度

1.452 g/cm3

分子量

242.229

沸点

溶解度

信号词

危险品标志

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化合物简介

胸苷（Thymidine），是一种化合物，更精确的名称是去氧胸苷，属于嘧啶去氧核苷。是DNA的原料之一。一般DNA碱基序列缩写的 ATGC 中的 T 就是胸苷（Thymidine）

基本信息

中文名称

胸苷

英文名称

thymidine

中文别名

β-胸腺嘧啶核苷、胸腺嘧啶核苷、1-(2-Deoxy-β-D-ribofuranosyl)-5-methyluraci、1-(2-Deoxy-β-D-ribofuranosyl)-5-methyluracil、1-(2-脱氧-β-D-呋喃核糖)-5-甲基尿嘧啶、2p-脱氧胸苷

英文别名

THYMIDINE、Zidovudine Related Compound D、Thymidine、DTHD、Thymine-2-deoxyriboside、2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-.β.-D-erythro-pentofuranosyl)-5-methyl-、2,4(1H,3H)-Pyrimidinedione,1-(2-deoxy-.Beta.-D-erythro-pentofuranosyl)-5-methyl、5-Methyldeoxyuridine、SS-THYMIDINE、Dthyd、1-(2-Deoxy-β-D-ribofuranosyl)thymine、Thyminedeoxyriboside、2\'-dT、Thymidin、b-Thymidine

CAS号

50-89-5

分子式

C10H14N2O5

分子量

242.229

精确质量

242.09

PSA

104.55

LOGP

-1.5143

编号系统

UNII

VC2W18DGKR

物化性质

外观与性状

白色结晶粉末

密度

1.452 g/cm3

熔点

187-189ºC

折射率

1.584

稳定性

Stable. Incompatible with strong oxidizing agents.

储存条件

0-6ºC

安全信息

RTECS号

XP2071000

安全说明

S22-S24/25

危险类别码

R20/21/22

WGK Germany

3

危险品标志

Xi

生产方法及用途

用途

治疗艾滋病药物齐多夫啶的中间体。

合成路线

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5’-O-三苯甲基胸苷

5’-O-三苯甲基胸苷

三苯基甲醇

三苯基甲醇

上游原料

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3',5'-O-bis(tetrahydropyran-2-yl)thymidine

3',5'-O-bis(tetrahydropyran-2-yl)thymidine

2'-脱氧尿苷

2'-脱氧尿苷

(2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl ethyl (((2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl) phosphate

(2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl ethyl (((2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl) phosphate

5S-(α-thymidyl)-5,6-dihydrothymidine

5S-(α-thymidyl)-5,6-dihydrothymidine

3,5-双-o-(t-丁基二甲基甲硅烷基)胸腺嘧啶脱氧核苷

3,5-双-o-(t-丁基二甲基甲硅烷基)胸腺嘧啶脱氧核苷

胸腺嘧啶脱氧核苷3-单磷酸铵盐水合物

胸腺嘧啶脱氧核苷3-单磷酸铵盐水合物

下游产品

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2'-脱氧尿苷

2'-脱氧尿苷

[(2R,3S,5R)-3-羟基-5-(5-甲基-2,4-二氧代-3,4-二氢-1(2H)-嘧啶基)四氢-2-呋喃基]甲基(3R,4S,5S,6R)-3,4,5-三羟基-6-(羟基甲基)四氢-2H-吡喃-2-基二氢二磷酸酯

[(2R,3S,5R)-3-羟基-5-(5-甲基-2,4-二氧代-3,4-二氢-1(2H)-嘧啶基)四氢-2-呋喃基]甲基(3R,4S,5S,6R)-3,4,5-三羟基-6-(羟基甲基)四氢-2H-吡喃-2-基二氢二磷酸酯

1-(2-脱氧-beta-D-赤式-呋喃戊糖基)-5-甲基-4-(1H-1,2,4-三唑-1-基)-2(1H)-嘧啶酮

1-(2-脱氧-beta-D-赤式-呋喃戊糖基)-5-甲基-4-(1H-1,2,4-三唑-1-基)-2(1H)-嘧啶酮

1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(((2-((1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl)phenyl)thio)methyl)pyrimidine-2,4(1H,3H)-dione

1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(((2-((1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl)phenyl)thio)methyl)pyrimidine-2,4(1H,3H)-dione

5,5'-二甲基-4,4'-联嘧啶-2,2',6(1H,3H,3'H)-三酮

5,5'-二甲基-4,4'-联嘧啶-2,2',6(1H,3H,3'H)-三酮

3,5-双-o-(t-丁基二甲基甲硅烷基)胸腺嘧啶脱氧核苷

3,5-双-o-(t-丁基二甲基甲硅烷基)胸腺嘧啶脱氧核苷

上游原料

3',5'-O-bis(tetrahydropyran-2-yl)thymidine 2'-脱氧尿苷 (2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl ethyl (((2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl) phosphate 5S-(α-thymidyl)-5,6-dihydrothymidine 3,5-双-o-(t-丁基二甲基甲硅烷基)胸腺嘧啶脱氧核苷胸腺嘧啶脱氧核苷3-单磷酸铵盐水合物 1-((2R,4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-4-((tert-butyldiphenylsilyl)oxy)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione Thymidine, 3-benzoyl- (5R,6R)-5-bromo-6-hydroxy-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,3-diazinane-2,4-dione 5,6-二羟基-1-[(2R,4S,5R)-4-羟基-5-(羟基甲基)四氢呋喃-2-基]-5-甲基-1,3-二嗪农-2,4-二酮 5-(phenylthiomethyl)-2'-deoxyuridine 3',5'-di-O-benzhydrylthymidine SP-thymidylyl-3',5'-thymidine phosphoromonothiolate 1-((2R,4S,5R)-4-((tert-butyldiphenylsilyl)oxy)-5-((trityloxy)methyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione 3',5'-二-O-苯甲酰基胸苷 1-[(2R,4S,5R)-4-hydroxy-5-[[(4-methoxyphenyl)-diphenylmethoxy]methyl]oxolan-2-yl]-5-methylpyrimidine-2,4-dione 3',5'-bis-O-(tert-butyldiphenylsilyl)-thymidine 3',5'-di-O-(p-chlorobenzoyl)-β-D-thymidine [(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl benzoate 5’-O-(叔丁基二甲基甲硅烷基)胸苷 5’-O-三苯甲基胸苷 3',5'-bis-O-(tert-butyldimethylsilyl)-5-(bromomethyl)-2'-deoxyuridine 1-[(2R,4S,5R)-4-iodo-5-(trityloxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione [(2R,3S,5R)-2-[[tert-butyl(dimethyl)silyl]oxymethyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl] acetate (2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (((2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl) methyl phosphate 1-((2R,4S,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-5-((phenylthio)methyl)pyrimidine-2,4(1H,3H)-dione 3',5'-di-O-levulinylthymidine 胸苷酸 3,5-双-O-乙酰胸苷保护胸苷 5'-O-(9-phenylthioxanthyl)-2'-deoxythimidine thymidine 5'-(3'',5''-dimethoxybenzoin)carbonate ((2R,3R,4R,5R)-3-(benzoyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-(3-(trifluoromethyl)phenoxy)tetrahydrofuran-2-yl)methyl benzoate 胸苷溴代醇 5-甲基脲嘧啶 2-溴-2-脱氧-5-甲基脲啶-3,5-二乙酸酯 (1s,3as,4r,7r,7ar)-octahydro-1h-4,7-methanoinden-1-ol (2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (((2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl) neopentyl phosphate 3',5'-di-O-methoxyacetylthymidine 5'-O-trityl-3'-O-tert-butyldimethylsilyl thymidine 1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-[(4-methylphenyl)sulfanylmethyl]pyrimidine-2,4-dione 苯甲醇 ((2R,3S,5R)-3-(hexanoyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl hexanoate RP-thymidylyl-3',5'-thymidine phosphoromonothiolate 3′,5′-di-O-trityl-thymidine phenacyl 5'-thymidine carbonate 1-((2R,4S,5R)-5-(((3-(dimethylamino)phenyl)diphenylmethoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione 溴脲苷

下游产品

2'-脱氧尿苷 [(2R,3S,5R)-3-羟基-5-(5-甲基-2,4-二氧代-3,4-二氢-1(2H)-嘧啶基)四氢-2-呋喃基]甲基(3R,4S,5S,6R)-3,4,5-三羟基-6-(羟基甲基)四氢-2H-吡喃-2-基二氢二磷酸酯 1-(2-脱氧-beta-D-赤式-呋喃戊糖基)-5-甲基-4-(1H-1,2,4-三唑-1-基)-2(1H)-嘧啶酮 1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(((2-((1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl)phenyl)thio)methyl)pyrimidine-2,4(1H,3H)-dione 5,5'-二甲基-4,4'-联嘧啶-2,2',6(1H,3H,3'H)-三酮 3,5-双-o-(t-丁基二甲基甲硅烷基)胸腺嘧啶脱氧核苷 S4-(2-CYANOETHYL)-5'-O-(DIMETHOXYTRITYL)-4-THIOTHYMIDINE 2-deoxy-D-ribofuranose N4-苯甲酰基-2'-脱氧-5-甲基胞苷 2,6-二氨基嘌呤-2’-脱氧核苷 5-氟-2'-脱氧脲核苷 5-氨基-2'-脱氧尿苷 2’,3’邻异亚丙基尿苷 5,6-二羟基-1-[(2R,4S,5R)-4-羟基-5-(羟基甲基)四氢呋喃-2-基]-5-甲基-1,3-二嗪农-2,4-二酮克拉屈滨乙去氧尿啶 3',5'-二-O-苯甲酰基胸苷 5’-O-(叔丁基二甲基甲硅烷基)胸苷 2-脱氧-D-核糖 (5R,5'S)-bi-5,6-dihydrothymidine (5S)-1-[(2S,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,3-diazinane-2,4-dione N(3)-乙基胸苷 5-(氢过氧基甲基)-1-[(2R,4S,5R)-4-羟基-5-(羟基甲基)四氢呋喃-2-基]嘧啶-2,4-二酮 2-Bromo-2’-deoxyinosine 1-(2-deoxy-β-D-erythro-pentofuranosyl)-2-thiouracil 胸苷5'-O-(1-硫代三磷酸酯) 保护胸苷 2-硫代-2’-脱氧胸苷 1-[(2R,4S,5S)-5-(chloromethyl)-4-hydroxyoxolan-2-yl]-5-methyl-4-(1,2,4-triazol-1-yl)pyrimidin-2-one cis-thymineglycol 5-氯-2-脱氧尿嘧啶核苷 benzoic acid 5-(4-benzoylamino-5-methyl-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 3`,5`-O-bis(4,4`-dimethoxy trityl)thymidine 1,2-二脱氧-D-核糖 5-甲基脲嘧啶 [7-15N]-2'-deoxyadenosine (R)-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methyldihydropyrimidine-2,4(1H,3H)-dione 2-deoxy-α-D-ribofuranose 1-phosphate 3’,5’-脱水胸苷碘苷 (+)-cis-(5S,6R)-5,6-dihydroxy-5,6-dihydrothymidine alpha,alpha-二氟胸苷溴脲苷 1-((2R,4S,5R)-4-羟基-5-(羟基甲基)四氢呋喃-2-基)-2,4-二氧代-1,2,3,4-四氢嘧啶-5-甲醛三氟胸苷 1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(((4-((1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl)phenyl)thio)methyl)pyrimidine-2,4(1H,3H)-dione (+)-trans-(5S,6S)-5,6-dihydroxy-5,6-dihydrothymidine 5-羟甲基脱氧尿苷