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保护胸苷

保护胸苷

CAS号：40615-39-2

英文名：5'-O-(4,4'-Dimethoxytrityl)thymidine

分子式

C31H32N2O7

熔点

114-116°C (subl.)(lit.)

密度

1.272 g/cm3

分子量

544.595

沸点

溶解度

信号词

Warning

危险品标志

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基本信息

中文名称

保护胸苷

英文名称

5'-O-(4,4'-Dimethoxytrityl)thymidine

中文别名

保护胸甙、5\'-O-(4,4\'-二甲氧基三苯甲基)胸苷、5\'-O-[双(4-甲氧基苯基)苄基]-2\'-胸腺嘧啶核苷、5\'-O-(4,4\'-二甲氧基三苯基甲基)胸苷、对苯二甲酸二甲酯胸腺嘧啶核甘

英文别名

5\'-O-Dimethoxytrityl-deoxythymidine、5‘-O-Dimethoxytrityl-deoxythymidine、1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione、5′-O-(4,4′-Dimethoxytrityl)thymidine

CAS号

40615-39-2

分子式

C31H32N2O7

分子量

544.595

精确质量

544.221

PSA

112.01

LOGP

3.5193

编号系统

EINECS号

255-003-1

物化性质

外观与性状

白色粉末

密度

1.272 g/cm3

熔点

114-116°C (subl.)(lit.)

折射率

7 ° (C=1, MeOH)

稳定性

Stable under normal temperatures and pressures.

储存条件

-20ºC

安全信息

安全说明

S26-S36

WGK Germany

3

危险类别码

R36/37/38

海关编码

29349990

危险品标志

Xi

危险性描述

H315; H319; H335

信号词

Warning

危险标志

GHS07

危险性防范说明

P261; P305 + P351 + P338

合成路线

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4,4'-双甲氧基三苯甲基氯

4,4'-双甲氧基三苯甲基氯

保护胸苷

3`,5`-O-bis(4,4`-dimethoxy trityl)thymidine

3`,5`-O-bis(4,4`-dimethoxy trityl)thymidine

上游原料

共找到25个上游原料 >

[5'-O-(4,4'-dimethoxytrityl)thymidine 3'-(H-phosphonate)](1-)*(CH3CH2)3NH(1+)

[5'-O-(4,4'-dimethoxytrityl)thymidine 3'-(H-phosphonate)](1-)*(CH3CH2)3NH(1+)

(2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl 2-(azidomethyl)benzoate

(2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl 2-(azidomethyl)benzoate

(2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (((2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl) methyl phosphate

(2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (((2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl) methyl phosphate

(2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl ethyl (((2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl) phosphate

(2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl ethyl (((2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl) phosphate

4,4'-双甲氧基三苯甲基氯

4,4'-双甲氧基三苯甲基氯

(MeO)2Tr-OAc

下游产品

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3’-O-乙酰胸苷

3’-O-乙酰胸苷

dithymidylyl-3',5'-phosphoroselenoate

dithymidylyl-3',5'-phosphoroselenoate

3'-O-(叔丁基二甲基硅烷基)胸苷

3'-O-(叔丁基二甲基硅烷基)胸苷

3’-脱氧-3-氟胸苷

3’-脱氧-3-氟胸苷

1,4-脱水-2-脱氧-3-O-[(叔丁基)二苯基硅]-D-赤式-戊-1-烯糖醇

1,4-脱水-2-脱氧-3-O-[(叔丁基)二苯基硅]-D-赤式-戊-1-烯糖醇

4-amino-1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-5-methylpyrimidin-2-one

4-amino-1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-5-methylpyrimidin-2-one

上游原料

[5'-O-(4,4'-dimethoxytrityl)thymidine 3'-(H-phosphonate)](1-)*(CH3CH2)3NH(1+) (2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl 2-(azidomethyl)benzoate (2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (((2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl) methyl phosphate (2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl ethyl (((2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl) phosphate 4,4'-双甲氧基三苯甲基氯 (MeO)2Tr-OAc 二(4-甲氧基苯基)(苯基)甲醇 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl ethyl phosphonate 1-(5-O-(4,4'-dimethoxytrityl)-3-C-(1,1-dimethylpropanoyl)-2-deoxy-β-D-threo-pentofuranosyl)thymine 5'-O-(4,4'-dimethoxytrityl)-3'-C-(2,2-dimethylpropanoyl)thymidine 5’-(4,4’-二甲氧基三苯基)-3’-脱氧胸苷 2’-(2-氰乙基-N,N-二异丙基)亚磷酰胺吡啶 (2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-((2,4-difluorobenzyl)(pyridin-2-yl)amino)ethyl) carbonate 5'-O-(4,4'-dimethoxytrityl)thymidine-3'-O-(2-cyanoethyl) H-phosphonate 5'-O-(4,4'-dimethoxytrityl)-3'-C-(benzoyl)thymidine (2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (((2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl) neopentyl phosphate 2’-氟-5-甲基阿拉伯糖基尿嘧啶 5'-DMTr-2,2'-anhydrothymidine 1-(5-O-(4,4'-dimethoxytrityl)-3-C-benzoyl-2-deoxy-β-D-threo-pentofuranosyl)thymine 1-(5-O-(4,4'-dimethoxytrityl)-3-C-acetyl-2-deoxy-β-D-threo-pentofuranosyl)thymine 5'-O-(4,4'-dimethoxytrityl)-3'-C-(acetyl)thymidine 3'-O-(4,4'-dimethoxytrityl)thymidin-5'-yl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl ethyl phosphonate p-chlorophenyl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl phosphonate 1-[5-O-[二(4-甲氧基苯基)苯甲基]-2-脱氧-2-氟-beta-D-阿拉伯呋喃糖基]-5-甲基-2,4(1H,3H)-嘧啶二酮胸苷

下游产品

3’-O-乙酰胸苷 dithymidylyl-3',5'-phosphoroselenoate 3'-O-(叔丁基二甲基硅烷基)胸苷 3’-脱氧-3-氟胸苷 1,4-脱水-2-脱氧-3-O-[(叔丁基)二苯基硅]-D-赤式-戊-1-烯糖醇 4-amino-1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-5-methylpyrimidin-2-one 5'-O-(4,4'-二甲氧基三苯甲基)-2'-脱氧胸苷-3'-(甲基-N,N-二异丙基)亚磷酰胺 S4-(2-CYANOETHYL)-5'-O-(DIMETHOXYTRITYL)-4-THIOTHYMIDINE N-苯甲酰基-5'-O-[二(4-甲氧基苯基)苯基甲基]-2'-脱氧-5-甲基胞苷 5-O-(4,4-二甲氧基三苯基甲基)-胸苷-3-O-丁二酸二(4-甲氧基苯基)(苯基)甲醇 2'-Deoxy-3'-O-[(2-methyl-2-propanyl)(diphenyl)silyl]-3,4-dihydrot hymidine [(2R,3S,5R)-3-羟基-5-(5-甲基-2,4-二氧代嘧啶-1-基)四氢呋喃-2-基]甲基[(2R,3S,5R)-2-(羟基甲基)-5-(5-甲基-2,4-二氧代嘧啶-1-基)四氢呋喃-3-基]甲基磷酸酯 3’-O-(4,4’-二甲氧基三苯甲基)胸苷 5’-(4,4’-二甲氧基三苯基)-3’-脱氧胸苷 2’-(2-氰乙基-N,N-二异丙基)亚磷酰胺 5-O-(4,4-二甲氧基三苯甲游基)-2,3-脱水胸腺嘧啶脱氧核苷 N,N-diisopropylamino-3'-O-[5'-O-(dimethoxytrityl) thymidine]thiomethoxyphosphine 胸苷