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(7S)-7-氨基-1,2,3,10-四甲氧基-6,7-二氢-5H-苯并[g]庚搭烯-9-酮

(7S)-7-氨基-1,2,3,10-四甲氧基-6,7-二氢-5H-苯并[g]庚搭烯-9-酮

CAS号：3476-50-4

英文名：Benzo[a]heptalen-9(5H)-one,7-amino-6,7-dihydro-1,2,3,10-tetramethoxy-, (7S)-

分子式

C20H23NO5

熔点

密度

1.25g/cm3

分子量

357.4

沸点

626.6ºC at 760mmHg

溶解度

信号词

危险品标志

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化合物简介

An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

基本信息

中文名称

(7S)-7-氨基-1,2,3,10-四甲氧基-6,7-二氢-5H-苯并[g]庚搭烯-9-酮

英文名称

Benzo[a]heptalen-9(5H)-one,7-amino-6,7-dihydro-1,2,3,10-tetramethoxy-, (7S)-

中文别名

英文别名

N-deacethylcolchicine、N-deacetylcolchicine、trimethylcolchicinic acid methyl ether、deacetylcolchicine、Desacetylcolchicine

CAS号

3476-50-4

分子式

C20H23NO5

分子量

357.4

精确质量

357.158

PSA

80.01

LOGP

3.3945

编号系统

UNII

2IAP3WIO1P

物化性质

密度

1.25g/cm3

沸点

626.6ºC at 760mmHg

闪点

287ºC

折射率

1.597

安全信息

WGK Germany

3

海关编码

2922509090

合成路线

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N-(tert-Butoxycarbonyl)deacetylcolchicine

N-(tert-Butoxycarbonyl)deacetylcolchicine

(7S)-7-氨基-1,2,3,10-四甲氧基-6,7-二氢-5H-苯并[g]庚搭烯-9-酮

(7S)-7-氨基-1,2,3,10-四甲氧基-6,7-二氢-5H-苯并[g]庚搭烯-9-酮

上游原料

共找到28个上游原料 >

重氮甲烷

(1R)-3-(2-ethynyl-3,4,5-trimethoxyphenyl)-1-(1,3-oxazol-2-yl)propan-1-ol

(1R)-3-(2-ethynyl-3,4,5-trimethoxyphenyl)-1-(1,3-oxazol-2-yl)propan-1-ol

7-amino-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one

7-amino-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one

(R/S)-N-Deacetyl Colchiceine N-Trifluroracetate

(R/S)-N-Deacetyl Colchiceine N-Trifluroracetate

4-((S)-6-(((allyloxy)carbonyl)amino)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)hexanamido)benzyl ((S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)carbamate

4-((S)-6-(((allyloxy)carbonyl)amino)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)hexanamido)benzyl ((S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)carbamate

5-(3-triisopropylsiloxypropyl)-4-iodo-1,2,3-trimethoxybenzene

5-(3-triisopropylsiloxypropyl)-4-iodo-1,2,3-trimethoxybenzene

下游产品

共找到12个下游商品 >

2,2-二甲基-N-[(7S)-1,2,3,10-四甲氧基-9-氧代-5,6,7,9-四氢苯并[a]庚搭烯-7-基]丙酰胺

2,2-二甲基-N-[(7S)-1,2,3,10-四甲氧基-9-氧代-5,6,7,9-四氢苯并[a]庚搭烯-7-基]丙酰胺

1,2,3,10-tetramethoxy-5,6-dihydrobenzo[a]heptalene-7,9-dione

1,2,3,10-tetramethoxy-5,6-dihydrobenzo[a]heptalene-7,9-dione

4-硝基-N-[(7S)-1,2,3,10-四甲氧基-9-氧代-6,7-二氢-5H-苯并[d]庚搭烯-7-基]苯甲酰胺

4-硝基-N-[(7S)-1,2,3,10-四甲氧基-9-氧代-6,7-二氢-5H-苯并[d]庚搭烯-7-基]苯甲酰胺

2-羟基-N-(1,2,3,10-四甲氧基-9-氧代-6,7-二氢-5H-苯并[d]庚搭烯-7-基)乙酰胺

2-羟基-N-(1,2,3,10-四甲氧基-9-氧代-6,7-二氢-5H-苯并[d]庚搭烯-7-基)乙酰胺

N-甲酰脱乙酰秋水仙碱

N-甲酰脱乙酰秋水仙碱

秋水仙碱

上游原料

重氮甲烷 (1R)-3-(2-ethynyl-3,4,5-trimethoxyphenyl)-1-(1,3-oxazol-2-yl)propan-1-ol 7-amino-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one (R/S)-N-Deacetyl Colchiceine N-Trifluroracetate 4-((S)-6-(((allyloxy)carbonyl)amino)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)hexanamido)benzyl ((S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)carbamate 5-(3-triisopropylsiloxypropyl)-4-iodo-1,2,3-trimethoxybenzene (+/-)-N-(trifluoroacetyl)deacetylcolchicine triisopropyl(3-(3,4,5-trimethoxyphenyl)propoxy)silane triisopropyl(3-(3,4,5-trimethoxy-2-((trimethylsilyl)ethynyl)phenyl)propoxy)silane 3-(3,4,5-三甲氧基苯基)-1-丙醇 3-(2-ethynyl-3,4,5-trimethoxyphenyl)propan-1-ol 3-(2-ethynyl-3,4,5-trimethoxyphenyl)-1-(1,3-oxazol-2-yl)propan-1-ol (S)-N-acetyl-3-(2-ethynyl-3,4,5-trimethoxyphenyl)-1-(2-oxazolyl)-propylamine 3-(2-ethynyl-3,4,5-trimethoxyphenyl)propanal 原秋水仙碱三甲基秋水仙素酸 (S)-N-7-acetylamino-12,13,14-trimethoxy-5-oxatricyclo[8.4.0.02,6]tetradeca-1(10),2(6),3,11,13-pentaene (S)-3-(2-ethynyl-3,4,5-trimethoxyphenyl)-1-(oxazol-2-yl)propan-1-amine N-甲酰脱乙酰秋水仙碱 (+/-)-N-deacetylcolchiceine (1R,2S,13R,14S)-2-tert-butoxycarbonylamino-7,8,9,14-tetramethoxy-17-oxatetracyclo[11.3.1.01,11.05,10]heptadeca-5(10),6,8,11(12)-tetraen-15-one 秋水仙碱 N-Boc-colchicine N-(tert-Butoxycarbonyl)deacetylcolchicine Benzyloxycarbonyl-L-phenylalanyl-L-lysyl-PABC-deacetylcolchicine (S)-7-tert-butoxycarbonylamino-12,13,14-trimethoxy-5-oxatricyclo[8.4.0.02,6]tetradeca-1(10),2(6),3,11,13-pentaene (R/S)-秋水仙碱 5-[(3S)-3-azido-3-(1,3-oxazol-2-yl)propyl]-4-ethynyl-1,2,3-trimethoxybenzene

下游产品

2,2-二甲基-N-[(7S)-1,2,3,10-四甲氧基-9-氧代-5,6,7,9-四氢苯并[a]庚搭烯-7-基]丙酰胺 1,2,3,10-tetramethoxy-5,6-dihydrobenzo[a]heptalene-7,9-dione 4-硝基-N-[(7S)-1,2,3,10-四甲氧基-9-氧代-6,7-二氢-5H-苯并[d]庚搭烯-7-基]苯甲酰胺 2-羟基-N-(1,2,3,10-四甲氧基-9-氧代-6,7-二氢-5H-苯并[d]庚搭烯-7-基)乙酰胺 N-甲酰脱乙酰秋水仙碱秋水仙碱 Demecolceine N-(1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl)butanamide (S)-6,7-二氢-1,2,3,10-四甲氧基-7-(苯甲酰基氨基)苯并[a]庚搭烯-9(5H)-酮脱羰秋水仙碱 2-苯氧基-N-(1,2,3,10-四甲氧基-9-氧代-5,6,7,9-四氢苯并[a]庚搭烯-7-基)乙酰胺 (S)-7-(二甲基氨基)-6,7-二氢-1,2,3,10-四甲氧基苯并[a]庚搭烯-9(5H)-酮