化合物简介
An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
基本信息
中文名称
Demecolceine
英文名称
(7S)-10-hydroxy-1,2,3-trimethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one
中文别名
英文别名
Demecolcein、(S)-10-hydroxy-1,2,3-trimethoxy-7-methylamino-6,7-dihydro-5H-benzo[a]heptalen-9-one、demecolceine、(S)-10-Hydroxy-1,2,3-trimethoxy-7-methylamino-6,7-dihydro-5H-benzo[a]heptalen-9-on、N-Desacetyl-N-methylcolchiceine、(7s)-9-hydroxy-1,2,3-trimethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-10(5h)-one
CAS号
518-11-6
分子式
C20H23NO5
分子量
357.4
精确质量
357.158
PSA
77.02
LOGP
3.0428
物化性质
密度
1.27g/cm3
沸点
626.4ºC at 760 mmHg
闪点
332.6ºC
折射率
1.608
上游原料
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