化合物简介
2-Carbomethoxytropinone (2-CMT) is a commonly used organic intermediate in the synthesis of cocaine and its analogues. As of at least 1999 no reaction pathway has been discovered that synthesizes cocaine-like compounds without utilizing the reduction of 2-CMT. The structure of cocaine was discovered by Richard Willstätter in 1898 after he synthesized it from 2-carbomethoxytropinone. Although it was originally believed that 2-CMT in nature was ultimately derived from ornithine and acetic acid, subsequent research has indicated other pathways exist for the biosynthesis of 2-CMT. A β-keto ester, 2-CMT exists in equilibrium with its keto–enol tautomer.
基本信息
中文名称
2甲酯-3-托品酮
英文名称
2-CARBOMETHOXY-3-TROPINONE
中文别名
2-甲氧羰基-3-托品酮、甲基 8-甲基-3-氧代双环[3.2.1]辛烷-2-甲酸酯
英文别名
CARBMETHOXY-TROPINONE、CARBOMETHOXY-TROPINONE、3-Oxo-tropan-2-carbonsaeure-methylester、3-oxo-tropane-2-carboxylic acid methyl ester
CAS号
36127-17-0
分子式
C10H15NO3
分子量
197.231
精确质量
197.105
PSA
46.61
LOGP
0.1491
物化性质
密度
1.173g/cm3
沸点
294.1ºC at 760mmHg
闪点
131.7ºC
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