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间硝基苯酚

间硝基苯酚

CAS号:554-84-7
英文名:3-nitrophenol
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化合物简介
3-Nitrophenol is a chemical reagent used in various organic syntheses. Used in the synthesis of RAGE inhibitors via the etherification of phenols. Also used in the synthesis of kinase inhibitors against epidermal growth factor receptor T790M mutation.
基本信息
编号系统
物化性质
安全信息
生产方法及用途
生产方法
由间硝基苯胺经重氮化;水解而得。将间硝基苯在搅拌下慢慢加入稀硫酸中,降温至0℃以下。在搅拌下慢慢加入亚硝酸钠水溶液,并保持温度在15℃以下,重氮化完成后反应液应为深棕色透明液体。再将重氮盐在搅拌下慢慢加入125℃的热稀硫酸中,加完后保温1-2h。放冷,将结晶滤出,用水洗至pH=3-4,滤干,减压蒸馏即得成品。
用途
用作指示剂,杀真菌剂和用于有机合成。
上游原料
1-but-3-enyloxy-3-nitrobenzene methyl (3-nitrophenyl) hydrogen phosphate cyclohepta(6-N-ethylformamido)amylose 3-溴硝基苯 Hexadecanoic acid 3-nitro-phenyl ester 对甲苯磺酸-3-硝基苯酯 3-nitrophenyl trifluoromethanesulfonate 1-nitro-3-prop-2-enoxybenzene Carbamic acid, N,N-diethyl-, 3-nitrophenyl ester ethyl (3-nitrophenyl) carbonate 2-甲氧基-6-硝基苯甲腈 溴代苯 N-((2S,3R,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-(3-nitrophenoxy)tetrahydro-2H-pyran-3-yl)-2,2,2-trifluoroacetamide 苯氧基自由基 N-((2S,3R,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-(3-nitrophenoxy)tetrahydro-2H-pyran-3-yl)-2-fluoroacetamide Phosphorsaeure-[O,O-dimethylester]-[O-3-nitro-phenyl-ester] 甘氨酸 3-nitrophenyl (2-(trimethylsilyl)ethyl) carbonate 1,3-二硝基苯 cyclohepta(6-N-methylformamido)amylose 乙二醇二甲醚 3,3-diethyl-1-(3-nitrophenyl)triaz-1-ene m-Nitrophenyl p-nitrobenzenesulphonate 氯苯 3-硝基氯苯 1-碘-3-硝基苯 3-nitrophenyl trifluoroacetates 3-nitrobenzenediazonium N-((2S,3R,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-(3-nitrophenoxy)tetrahydro-2H-pyran-3-yl)-2,2-difluoroacetamide Octanoic acid 3-nitro-phenyl ester 甲基亚硝基脲 (3-nitrophenyl) acetate 3-硝基苯硼酸 硝基苯 m-nitrophenyl pentanoate 3-硝基苯硼酸频哪醇酯 3-硝基苯磺酸钠 甲醇钠 间硝基苯胺 (3-nitrophenyl) 3-phenylprop-2-enoate 3-硝基苯甲醚 (3-nitrophenyl) 9H-fluorene-9-carboxylate 甲醇 1-nitro-3-phenylmethoxybenzene 2-(3-nitrophenoxy)oxane N-((2S,3R,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-(3-nitrophenoxy)tetrahydro-2H-pyran-3-yl)pentanamide β-环糊精 (3-nitrophenyl) benzoate 3-硝基苯乙醚