百科

奎尼丁

奎尼丁

CAS号：56-54-2

英文名：Quinidine

分子式

C20H24N2O2

熔点

168-172°C(lit.)

密度

0.05 g/100 mL (20ºC)

分子量

324.417

沸点

495.9ºC at 760 mmHg

溶解度

0.05 g/100 mL (20 ºC)

信号词

危险品标志

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化合物简介

A dextrorotatory stereoisomer of Quinine. Antiarrhythmic (class IA). Antimalarial.

基本信息

中文名称

奎尼丁

英文名称

Quinidine

中文别名

(+)-喹纳定、异奎宁、奎尼定、异性金鸡钠碱、奎宁丁

英文别名

Conchinin、Raclopride、QUINDINE、Chinidin、Cinchonan-9-ol, 6\'-methoxy-, (9S)-、Kinidin、Cin-quin、Quinidex、QUNIDINE、Quinidine,(S)-(6-Methoxyquinolin-4-yl)((2R,4S,8R)-8-vinylquinuclidin-2-yl)methanolhydrochloride、PITAYINE、Quinidine、Pitayin、Coccinine

CAS号

56-54-2

分子式

C20H24N2O2

分子量

324.417

精确质量

324.184

PSA

45.59

LOGP

3.1111

编号系统

MDL号

MFCD00135581

物化性质

外观与性状

白色至淡黄色晶体粉末

密度

0.05 g/100 mL (20ºC)

沸点

495.9ºC at 760 mmHg

熔点

168-172°C(lit.)

闪点

253.7ºC

水溶解性

0.05 g/100 mL (20 ºC)

稳定性

Stable. Incompatible with strong oxidizing agents.

储存条件

Keep containers tightly closed. Store protected from light. Store in a cool, dry area away from incompatible substances.

安全信息

RTECS号

VA4725000

安全说明

S36-S22

WGK Germany

3

危险类别码

R22

海关编码

2933990090

危险品运输编码

UN 2811 6.1/PG 3

危险类别

6.1(b)

包装等级

III

危险品标志

Xn

生产方法及用途

生产方法

为金鸡纳皮所含生物碱，是奎宁的异构体。可由金鸡纳树皮中提取奎宁、辛可宁、辛可尼丁后，从母液中提取奎宁丁，再用硫酸处理而制得。

用途

手性催化剂。医药。

合成路线

共找到16条合成路线 >

奎尼丁

奎宁酮

6'-甲氧基脱氧辛可宁-9-酮

6'-甲氧基脱氧辛可宁-9-酮

维喹地尔

奎尼丁

上游原料

共找到46个上游原料 >

2-(trimethylsilyl)ethyl (3R,4S)-4-(2-oxoethyl)-3-vinylpiperidine-1-carboxylate

2-(trimethylsilyl)ethyl (3R,4S)-4-(2-oxoethyl)-3-vinylpiperidine-1-carboxylate

((3R,4S)-4-(2-hydroxyethyl)-3-vinylpiperidin-1-yl)(phenyl)methanone

((3R,4S)-4-(2-hydroxyethyl)-3-vinylpiperidin-1-yl)(phenyl)methanone

6-甲氧基-4-甲基喹啉水合物

6-甲氧基-4-甲基喹啉水合物

2-(trimethylsilyl)ethyl (3R,4S)-4-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-3-(2-hydroxyethyl)piperidine-1-carboxylate

2-(trimethylsilyl)ethyl (3R,4S)-4-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-3-(2-hydroxyethyl)piperidine-1-carboxylate

(1S)-((2R,4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)quinuclidin-2-yl)(6-methoxyquinolin-4-yl)methanol

(1S)-((2R,4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)quinuclidin-2-yl)(6-methoxyquinolin-4-yl)methanol

N-benzyl-N-(but-3-enyl)-but-3-en-1-amine

N-benzyl-N-(but-3-enyl)-but-3-en-1-amine

下游产品

共找到22个下游商品 >

6-甲氧基-4-羧酸喹啉

6-甲氧基-4-羧酸喹啉

N-苄基氯化喹啶嗡

N-苄基氯化喹啶嗡

氢化奎宁定

氢化奎宁定

(3Z)-6'-甲氧基-3,5'-二去氢-5',11-二氢脱氧辛可宁-9-基乙酸酯

(3Z)-6'-甲氧基-3,5'-二去氢-5',11-二氢脱氧辛可宁-9-基乙酸酯

上游原料

2-(trimethylsilyl)ethyl (3R,4S)-4-(2-oxoethyl)-3-vinylpiperidine-1-carboxylate ((3R,4S)-4-(2-hydroxyethyl)-3-vinylpiperidin-1-yl)(phenyl)methanone 6-甲氧基-4-甲基喹啉水合物 2-(trimethylsilyl)ethyl (3R,4S)-4-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-3-(2-hydroxyethyl)piperidine-1-carboxylate (1S)-((2R,4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)quinuclidin-2-yl)(6-methoxyquinolin-4-yl)methanol N-benzyl-N-(but-3-enyl)-but-3-en-1-amine (1S)-((2R,4S,5R)-5-formylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methyl acetate benzyl dibut-3-enylcarbamate 2-(trimethylsilyl)ethyl (3R,4S)-4-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-3-vinylpiperidine-1-carboxylate ((3R,4R)-3-(((tert-butyldimethylsilyl)oxy)methyl)-4-((E)-3-(6-methoxyquinolin-4-yl)allyl)piperidin-1-yl)(phenyl)methanone ((3R,4S)-3-(((tert-butyldimethylsilyl)oxy)methyl)-4-((2S,3S)-2,3-dihydroxy-3-(6-methoxyquinolin-4-yl)propyl)piperidin-1-yl)(phenyl)methanone (1S)-((2R,4S,5R)-5-(hydroxymethyl)quinuclidin-2-yl)(6-methoxyquinolin-4-yl)methyl acetate diethyl ((6-methoxyquinolin-4-yl)methyl)phosphonate 2-(trimethylsilyl)ethyl (3R,4S)-4-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-3-(2-(pivaloyloxy)ethyl)piperidine-1-carboxylate ((3R,4S)-4-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-3-vinylpiperidin-1-yl)(phenyl)methanone benzyl bis(3,4-dihydroxybutyl)carbamate 2-((3R,4S)-1-benzyl-4-(2-((tert-butyldiphenylsilyl)oxy)ethyl)piperidin-3-yl)ethyl pivalate 奎尼丁 4-羟基甲基-6-甲氧基喹啉 ethyl (3R,4S)-4-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-3-(2-(pivaloyloxy)ethyl)piperidine-1-carboxylate (3R,4S)-6-((tert-butyldiphenylsilyl)oxy)-4-(2-hydroxyethyl)-3-(hydroxymethyl)hexyl pivalate (3R,4R)-6-((tert-butyldiphenylsilyl)oxy)-4-(2-iodoethyl)-3-(iodomethyl)hexyl pivalate 4-chloromethyl-6-methoxyquinoline 醋酸 benzyl bis(2-formylethyl)carbamate 6-甲氧基-4-喹啉甲醛 ethyl (3R,4S)-4-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-3-vinylpiperidine-1-carboxylate 乙酰基乙酰对甲氧基苯胺 (4S)-[3-(6-methoxyquinolin-4-yl)-(S,S)-oxiranylmethyl]-(3R)-vinylpiperidine-1-carboxylic acid benzyl ester 2-(trimethylsilyl)ethyl (3R,4S)-4-((2S,3S)-2,3-dihydroxy-3-(6-methoxyquinolin-4-yl)propyl)-3-vinylpiperidine-1-carboxylate benzyl (R)-3-(tert-butyldimethylsilyloxymethyl)-4-oxopiperidine-1-carboxylate 2-(trimethylsilyl)ethyl (3R,4S)-4-(((2S,3S)-3-(6-methoxyquinolin-4-yl)oxiran-2-yl)methyl)-3-vinylpiperidine-1-carboxylate benzyl (R,Z)-3-((tert-butyldimethylsilyloxy)methyl)-4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate blue acetylquinine ((3R,4R)-4-((E)-3-(6-methoxyquinolin-4-yl)allyl)-3-vinylpiperidin-1-yl)(phenyl)methanone 2-(trimethylsilyl)ethyl (3R,4R)-4-((E)-3-(6-methoxyquinolin-4-yl)allyl)-3-vinylpiperidine-1-carboxylate ((3R,4S)-4-(((2S,3S)-3-(6-methoxyquinolin-4-yl)oxiran-2-yl)methyl)-3-vinylpiperidin-1-yl)(phenyl)methanone (+)-N-benzoylmeroquinene aldehyde ((3R,4S)-4-((2S,3S)-2,3-dihydroxy-3-(6-methoxyquinolin-4-yl)propyl)-3-vinylpiperidin-1-yl)(phenyl)methanone 1-((3R,4S)-1-benzoyl-3-(((tert-butyldimethylsilyl)oxy)methyl)piperidin-4-yl)-3-(6-methoxyquinolin-4-yl)propan-2-one (1S)-((2R,4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)quinuclidin-2-yl)(6-methoxyquinolin-4-yl)methyl acetate ethyl 2-((3R,4S)-1-benzoyl-3-((tert-butyldimethylsilyloxy)methyl)piperidin-4-yl)acetate 4-((2S,3S)-3-(((3R,4S)-3-(((tert-butyldimethylsilyl)oxy)methyl)piperidin-4-yl)methyl)oxiran-2-yl)-6-methoxyquinoline

下游产品

6-甲氧基-4-羧酸喹啉甲酸氨气 N-苄基氯化喹啶嗡氢化奎宁定 (3Z)-6'-甲氧基-3,5'-二去氢-5',11-二氢脱氧辛可宁-9-基乙酸酯草酸 6'-甲氧基辛可宁-9-酮 (6-甲氧基-4-喹啉基)(5-氧代-1-氮杂双环[2.2.2]辛-2-基)甲基乙酸酯奎尼丁铜色树碱 N-[3,5-双(三氟甲基)苯基]-N′-[(9R)-6′-甲氧基-9-金鸡宁]硫脲维喹地尔 D-(-)-泛酰内酯奎宁酮盐酸奎宁 6'-甲氧基脱氧辛可宁-9-酮 O-(4-氯苯甲酰)氢奎并啶 pyridine-2,3,4-tricarboxylic acid