化合物简介
L-741,626 is a drug which acts as a potent and selective antagonist for the dopamine receptor D2. It has good selectivity over the related D3 and D4 subtypes and other receptors. L-741,626 is used for laboratory research into brain function and has proved particularly useful for distinguishing D2 mediated responses from those produced by the closely related D3 subtype, and for studying the roles of these subtypes in the action of cocaine and amphetamines in the brain.
基本信息
中文名称
(±)-3-[4-(4-Chlorophenyl)-4-hydroxypiperidinyl]methylindole
英文名称
4-(4-chlorophenyl)-1-(1H-indol-3-ylmethyl)piperidin-4-ol
中文别名
英文别名
4-(4-Chlorophenyl)-1-(1H-indol-3-ylmethyl)-4-piperidinol、L 741,626、1-(indol-3-ylmethyl)-4-hydroxy-4-(p-chlorophenyl)piperidine、4-Piperidinol,4-(4-chlorophenyl)-1-(1H-indol-3-ylmethyl)、3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole
CAS号
81226-60-0
分子式
C20H21ClN2O
分子量
340.847
精确质量
340.134
PSA
39.26
LOGP
4.2428
物化性质
密度
1.311g/cm3
沸点
548.8ºC at 760 mmHg
闪点
285.7ºC
折射率
1.686
合成路线