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孕烯醇酮

孕烯醇酮

CAS号：145-13-1

英文名：pregnenolone

分子式

C21H32O2

熔点

188-190°C

密度

1.09 g/cm3

分子量

316.478

沸点

443.3ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

Pregnenolone is a steroid hormone involved in the steroidogenesis of progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. As such it is a prohormone. Pregnenolone is a GABAA antagonist and increases neurogenesis in the hippocampus. It is a modulator of cytochrome P 450-3A .

基本信息

中文名称

孕烯醇酮

英文名称

pregnenolone

中文别名

孕甾烯醇酮、3β-羟基孕甾-5-烯-20-酮、5-孕甾烯-3β-醇-20-酮、5-Pregnen-3β-ol-20-one、妊娠烯醇酮

英文别名

3β-Hydroxy-5-pregnen-20-one、prenolon、ZK-5553、Pregn-5-en-20-one, 3-hydroxy-, (3β)-、pregnolon、prenenolone、Pregnelone、Pregnenlolone、Pregnenolone、Progeserone

CAS号

145-13-1

分子式

C21H32O2

分子量

316.478

精确质量

316.24

PSA

37.3

LOGP

4.5153

编号系统

RTECS号

TU5560700

PubChem号

24899008

EINECS号

205-647-4

MDL号

MFCD00003628

物化性质

外观与性状

白色至灰白色粉末

密度

1.09 g/cm3

沸点

443.3ºC at 760 mmHg

熔点

188-190°C

闪点

188.9ºC

折射率

1.549

蒸汽压

1.02E-09mmHg at 25°C

安全信息

RTECS号

TU5560700

安全说明

S22-S24/25

WGK Germany

3

海关编码

2937290090

生产方法及用途

生产方法

将乙酸妊娠双烯醇酮、乙醇、雷氏镍一起加热,50℃左右使全部溶解,然后抽真空通入氢气,反复3次后,在搅拌下通氢,在34-36℃反应3.5h。静置,通氮气排出氢气,滤出催化剂。将滤液浓缩回收大部分乙醇,析出结晶。将结晶投入水解锅内减压蒸尽乙醇,冷却后加入甲醇,加热回流使全部溶解,加入50%碳酸钾水溶液,回流1.5h,减压浓缩回收甲醇,出料后冷却至5℃以下,滤取结晶,用温水洗至中性,烘干。再用10倍量乙醇溶解,加活性炭脱色,重结晶1次,得妊烯醇酮。

用途

孕烯醇酮是合成黄体酮、非那甾胺等的重要中间体。

合成路线

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胆固醇

黄体酮

孕烯醇酮

20β-羟基黄体酮

20β-羟基黄体酮

(20R)-20-Hydroxy-5-pregnen-3-on

(20R)-20-Hydroxy-5-pregnen-3-on

11β,20β-Dihydroxy-3-keto-Δ4-pregnen

11β,20β-Dihydroxy-3-keto-Δ4-pregnen

海关数据

共找到1个国家海关数据 >

国家/地区名称	海关编码	更新时间	操作
中国	2937290090	2019-03	查看

上游原料

共找到58个上游原料 >

furosta-5,20(22)-dien-3,26-diyl diacetate

furosta-5,20(22)-dien-3,26-diyl diacetate

乙醇钠

(8S,9S,10R,13S,14S)-10,13-dimethyl-17-(2-methyl-1,3-dithiolan-2-yl)-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol

(8S,9S,10R,13S,14S)-10,13-dimethyl-17-(2-methyl-1,3-dithiolan-2-yl)-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol

环孕甾醇

3β-hydroxy-androstene-(5)-carboxylic acid-(17β)-nitrile

3β-hydroxy-androstene-(5)-carboxylic acid-(17β)-nitrile

下游产品

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雄烯二醇

18,20-环-20,21-二羟基-4-孕烯-3-酮

18,20-环-20,21-二羟基-4-孕烯-3-酮

1-[(8S,9S,10R,13S,14S,17S)-10,13-dimethyl-2,7,8,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone

1-[(8S,9S,10R,13S,14S,17S)-10,13-dimethyl-2,7,8,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone

5,6alpha-环氧-3beta-羟基-5alpha-孕甾烷-20-酮

5,6alpha-环氧-3beta-羟基-5alpha-孕甾烷-20-酮

21-乙酰氧基孕烯醇酮

21-乙酰氧基孕烯醇酮

上游原料

furosta-5,20(22)-dien-3,26-diyl diacetate 溴乙醇钠 (8S,9S,10R,13S,14S)-10,13-dimethyl-17-(2-methyl-1,3-dithiolan-2-yl)-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol 环孕甾醇 3β-hydroxy-androstene-(5)-carboxylic acid-(17β)-nitrile 17-氰基-5,16-雄甾二烯-3 beta-醇-3-乙酸酯皂素 6β-Acetoxy-3α,5α-cyclopregnan-20-on 21-diazo-3β-hydroxy-pregn-5-en-20-one pregnadiene-(5,17(20)c)-diyl-(3β,20)-diacetate 孕烯诺龙乙酸酯乙醇 [(3S,8R,9S,10R,13S,14S,17E)-17-(1-acetyloxyethylidene)-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-yl] acetate 3β-acetoxy-24,24-diphenyl-chola-5,20(22)ξ,23-triene 3-O-(3'-phenyl-2'-isoxazoline-5'-carbonyl)pregnenolone (1aR,3aR,3bS,5aS,6R,8aS,8bS,10R,10aR)-6-((R,Z)-4-ethyl-6-methylhept-2-en-2-yl)-10-methoxy-3a,5a-dimethylhexadecahydrocyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalene (23R)-23-ethylcholesta-5,20(22)-dien-3β-ol 3β-acetoxy-20-methyl-21.21-diphenyl-pregnadiene-(5.20) 3β-acetoxy-5-chloro-5α-pregnan-20-one (20R)-3β,20,26-trihydroxy-27-norcholest-5-en-22-one 黄体酮 16-脱氢孕烯醇酮乙酸酯重氮丙酸二乙酯 16-妊娠双烯醇酮 3β-acetoxy-24,24-diphenyl-chola-5,23-diene 重氮甲烷 Toluene-4-sulfonic acid (3S,8S,9S,10R,13S,14S,17R)-17-((Z)-(R)-3-ethyl-1,5-dimethyl-hex-1-enyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester 乙酸乙酯 3β-formyloxypregn-5-en-20-one 3β-acetoxy-Δ5-etiocholenic acid chloride 盐酸 3alpha,5alpha-环胆甾烷-6beta-醇 Androst-5-ene-17-carboxylic acid, 3-hydroxy-, methyl ester, (3β,17α)- (Z)-3β,20-diacetoxy-pregna-5,17(20)-diene 5-chloro-3β-acetoxy-24.24-diphenyl-5α-cholene-(23) 丙二酸二乙酯钠盐 5alpha,6beta-二溴豆甾烷-3beta-基3-乙酸酯胆固醇 (20S)-3β-acetoxy-5-pregnen-20-amine (1aR,3aR,3bS,5aR,6R,8aS,8bS,10R,10aR)-3a,5a-dimethyl-6-((R)-6-methylheptan-2-yl)hexadecahydrocyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-10-yl 2-(4'-iodo-[1,1'-biphenyl]-3-yl)acetate 乙醚 3β-hydroxypregn-5-ene-16,20-dione 甲醇去氢表雄酮孕甾-5-烯-3,20-二酮溴甲基甲基醚猪去氧胆酸 magnesium,carbanide,iodide

下游产品

雄烯二醇 18,20-环-20,21-二羟基-4-孕烯-3-酮睾酮 1-[(8S,9S,10R,13S,14S,17S)-10,13-dimethyl-2,7,8,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone 5,6alpha-环氧-3beta-羟基-5alpha-孕甾烷-20-酮 21-乙酰氧基孕烯醇酮 11-去氢皮质甾酮 5-孕烯-3-beta,16-alpha-二醇-20-酮 3beta-羟基孕甾-5-烯-20-酮肟 3-乙酸酯 17Alpha-羟基黄体酮 20β-羟基黄体酮 15alpha-羟基黄体酮 (20R)-20-Hydroxy-5-pregnen-3-on 睾内酯 17beta-乙酰基-5,6alpha-环氧-5alpha-雄甾烷-3beta-醇乙酸酯孕烯诺龙乙酸酯 17Alpha-羟基妊娠烯醇酮雄烯二酮 1-(6-fluoro-3,5-dihydroxy-10,13-dimethyl-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl)ethanone (3S,8S,9S,10R,13R,14S)-10,13-二甲基-2,3,4,7,8,9,11,12,14,15-十氢-1H-环戊并[a]菲-3-醇 1-[3-(methoxymethoxy)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone 黄体酮雄甾-5-烯-3-beta,17-alpha-二醇 11β,20β-Dihydroxy-3-keto-Δ4-pregnen 7α,15β-dihydroxypregn-4-en-3,20-dione 醛固酮氢化可的松 5-孕烯-3beta,20Beta-二醇脱氧可的松 5beta-孕甾烷-3,20-二酮 5α-二氢睾酮 11α,15β-dihydroxypregn-4-ene-3,20-dione 氢化黄体酮 4-孕烯-20-alpha-醇-3-酮 17-acetyl-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl 2-(4-(bis(2-chloroethyl)amino)phenyl)acetate 14,15β-Dihydroxy-14α-pregnen-(4)-dion-(3,20) 11Alpha-孕酮 17α-Hydroperoxy-5-pregnen-3β-ol-20-on 别孕烯醇酮 3-氧代-雄甾-4-烯-17beta-羧酸去氢表雄酮孕甾-5-烯-3,20-二酮 3,20-别孕甾烷二酮 6-去氢黄体酮 20β-hydroxy-pregna-3,5-diene 去氧皮质酮 [(8S,9S,10R,13S,14S,17R)-5,6,17-tribromo-17-(2-bromoacetyl)-10,13-dimethyl-2,3,4,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate