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黄体酮

黄体酮

CAS号：57-83-0

英文名：Progesterone

分子式

C21H30O2

熔点

128-132°C(lit.)

密度

1.08g/cm3

分子量

314.462

沸点

447.2ºC at 760mmHg

溶解度

信号词

Warning

危险品标志

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化合物简介

Steroid hormone produced by the corpus luteum. Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer.

基本信息

中文名称

黄体酮

英文名称

Progesterone

中文别名

孕烯二酮、孕酮、孕甾-4-烯-3,20-二酮、助孕素、黄体甾酮、助孕激素、黄体素、助孕酮

英文别名

Luteol、lutren、Luteum、Lutein、CIDR、pregn-4-en-3,20-dione、Gestron、U 3672、D4-pregnene-3,20-dione、Lutin、Pregn-4-ene-3,20-dione、Crinone、4-Pregnene-3,20-dione、Lutex、Progesterone、P4

CAS号

57-83-0

分子式

C21H30O2

分子量

314.462

精确质量

314.225

PSA

34.14

LOGP

4.7235

编号系统

UNII

4G7DS2Q64Y

物化性质

外观与性状

结晶粉末

密度

1.08g/cm3

沸点

447.2ºC at 760mmHg

熔点

128-132°C(lit.)

闪点

166.7ºC

折射率

182 ° (C=2, Dioxane)

稳定性

Stable. Incompatible with strong oxidizing agents.

储存条件

Store in a cool, dry place. Store in a tightly closed container. Hormones and antibiotics room.

安全信息

RTECS号

TW0175000

安全说明

S36/37-S45

WGK Germany

3

危险类别码

R40

危险品标志

Xn

信号词

Warning

危险性防范说明

P280

危险性描述

H351; H361

危险标志

GHS08

生产方法及用途

生产方法

由妊烯醇酮氧化得到。将干燥的甲苯加入干燥的反应锅内,加入环已酮及妊烯醇酮,搅拌溶解,蒸甲苯脱水至尽,迅速加入异丙醇铝,于115℃氧化反应2h,冷却至80℃左右,在搅拌下加入5%稀硫酸,静置分层,分去水层,甲苯层用水洗至中性后进行水蒸气蒸馏,蒸出甲苯及环已酮。冷却,过滤,滤渣用石油醚搅成浆状,过滤,以石油醚洗涤,干燥得黄体酮粗品。粗品溶于乙醇,用活性炭脱色,重结晶成品,收率80%。

用途

孕激素类药物。

合成路线

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孕烯醇酮

黄体酮

5α-二氢睾酮

5α-二氢睾酮

去氢表雄酮

去氢表雄酮

雄烯二酮

上游原料

共找到134个上游原料 >

3-巯基丙酸

furosta-5,20(22)-dien-3,26-diyl diacetate

furosta-5,20(22)-dien-3,26-diyl diacetate

21-Ethoxypregn-4-ene-3,20-dione

21-Ethoxypregn-4-ene-3,20-dione

5α,6β-dibromocholestan-3β-ol

5α,6β-dibromocholestan-3β-ol

下游产品

共找到98个下游商品 >

15β,17α-dihydroxy-4-pregnen-3,20-dione

15β,17α-dihydroxy-4-pregnen-3,20-dione

18,20-环-20,21-二羟基-4-孕烯-3-酮

18,20-环-20,21-二羟基-4-孕烯-3-酮

17β-hydroxyandrostan-3-one

17β-hydroxyandrostan-3-one

孕烷醇酮

17Alpha-羟基黄体酮

17Alpha-羟基黄体酮

上游原料

3-巯基丙酸溴 furosta-5,20(22)-dien-3,26-diyl diacetate 氯仿 21-Ethoxypregn-4-ene-3,20-dione 5α,6β-dibromocholestan-3β-ol pregn-4-ene-3,20-diol 28-acetyl-22R,25R-spirosolan-4-en-3-one (22R,25R)-螺旋甾碱-4-烯-3-酮 21-tert-Butyldimethylsilyloxy-3,3:20,20-bis(ethylenedioxy)-pregn-5-en-11-one 孕烯醇酮 17α-methoxy-21-hydroxy-4-pregnene-3,20-dione Desoxy-corticosteron-triphenylmethylether 20ξ-(Diethylphosphono)-20ξ-isocyano-3-methoxypregna-3,5-diene 硫酸黄体酮环20-(乙烯缩醛) 麦角固醇 16-去氢黄体酮 21-methoxyprogesterone 四氯化碳 1-((8S,9S,10R,13S,14S,17S)-10,13-dimethyl-1,2,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolan]-17-yl)ethanone 16-妊娠双烯醇酮 11-deoxy-21-iodocorticosterone 3-甲氧基雄甾-3,5-二烯-17-酮 4-胆甾烯-3-酮 6β-bromo-4-pregnene-3,20-dione 5-孕烯-3beta,20Beta-二醇 2-acetoxy-5,5,20,20-bis(ethylenedioxy)-4,5-secopregnan-3-one 脱氧可的松 5beta-孕甾烷-3,20-二酮 3β-hydroxy-pregn-5-en-20-one semicarbazone 苯 3α,6α-diacetoxy-5β-pregnanone-(20) 21-Propoxypregn-4-ene-3,20-dione (8S,9S,10R,13S,14S,16S,17R)-17-acetyl-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-16-yl (R)-5-acetamido-4-methylpentanoate (E)-17-<(Diethylphosphono)formamidomethylene>-3-methoxyandrosta-3,5-diene (8S,9S,10R,13R,14S,17S)-10,13-dimethyl-17-(2-methyl-1,3-dioxolan-2-yl)-1,2,4,7,8,9,10,13,14,15,16,17-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolan]-11-yl diethyl phosphate 3,3,20,20-bis-ethanediyldioxy-pregn-5-en-11-one (E)-17-((Diethylphosphono)isocyanomethylene)-3-methoxyandrosta-3,5-diene (8S,9S,10R,13S,14S,17S)-10,13-dimethyl-17-(2-methyl-1,3-dioxolan-2-yl)-1,2,4,7,8,9,10,13,14,15,16,17-dodecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxolane] 3,3-ethanediyldimercaptopregn-4-en-20-one 二去甲胆烯醛 (20ξ)-17β-<(Diethylphosphono)isocyanomethyl>-3-methoxyandrosta-3,5-diene N-((R)-2-methyl-4-((6aR,6bS,8aS,8bS,11aS,12aS,12bS)-6a,8a,9-trimethyl-4-oxo-2,4,5,6,6a,6b,7,8,8a,8b,11a,12,12a,12b-tetradecahydro-1H-naphtho[2',1':4,5]indeno[2,1-b]furan-10-yl)butyl)acetamide 1,4-孕甾二烯-3,20-二酮 Progesterone dibromide 去氧皮质酮

下游产品

15β,17α-dihydroxy-4-pregnen-3,20-dione 18,20-环-20,21-二羟基-4-孕烯-3-酮 17β-hydroxyandrostan-3-one 睾酮孕烷醇酮 17Alpha-羟基黄体酮 11α,17β-Dihydroxy-5α-androstan-3-on 15alpha-羟基黄体酮 20β-羟基黄体酮睾内酯雄烯二酮雄甾-1,4-二烯-3,17-二酮 7α,15β-dihydroxypregn-4-en-3,20-dione 3-beta,17-alpha-二羟基-5-alpha-孕甾烷-20-酮氢化可的松还原胆烷醇酮 4-孕烯-7beta-醇-3,20-二酮 5alpha-孕甾-3alpha-醇-20-酮 11beta,18-环氧-18,21-二羟基孕甾-4-烯-3,20-二酮 17-acetyl-6,11-dihydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one 5-孕烯-3beta,20Beta-二醇 N-[(Z)-[17-[(E)-N-(2,4-dinitroanilino)-C-methylcarbonimidoyl]-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-ylidene]amino]-2,4-dinitroaniline 睾内酯脱氧可的松 3Beta-羟基-5-beta-妊娠-20-酮 11β,18,21-trihydroxy-4-pregnen-3,20-dione 5beta-孕甾烷-3,20-二酮 11α,15β-dihydroxypregn-4-ene-3,20-dione 氢化黄体酮 (8S,9S,10R,13S,14S)-11,17-dihydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one 4-孕烯-20-alpha-醇-3-酮 5a-雄甾烷二酮醋酸睾酮宝丹酮孕甾二醇 14,15β-Dihydroxy-14α-pregnen-(4)-dion-(3,20) 5β-雄烷-3,17-二酮 11Alpha-孕酮 5-Alpha-妊娠-3-alpha-17-二醇-20-酮别孕烯醇酮 1,4-孕甾二烯-3,20-二酮 3-氧代-雄甾-4-烯-17beta-羧酸孕甾烷醇酮3-beta-D-葡糖苷酸去氧皮质酮 1-acetyl-6,9a,11a-trimethyl-2,3,3a,3b,4,8,9,9b,10,11-decahydro-1H-indeno[5,4-f]quinolin-7-one 5-Alpha-孕烷-3-beta, 20-alpha-二醇