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7-乙基-10-羟基喜树碱

7-乙基-10-羟基喜树碱

CAS号：86639-52-3

英文名：7-Ethyl-10-hydroxycamptothecin

分子式

C22H20N2O5

熔点

217 °C

密度

1.51 g/cm3

分子量

392.405

沸点

810.3ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

SN-38 is an antineoplastic drug. It is the active metabolite of irinotecan (an analog of camptothecin - a topoisomerase I inhibitor) but has 1000 times more activity than irinotecan itself. In vitro cytotoxicity assays show that the potency of SN-38 relative to irinotecan varies from 2- to 2000-fold.

基本信息

中文名称

7-乙基-10-羟基喜树碱

英文名称

7-Ethyl-10-hydroxycamptothecin

中文别名

7-乙基-10羟基喜树碱、7-乙基-10-羟基喜树、伊立替康杂质B、盐酸苄唑啉.盐酸妥拉唑林

英文别名

7-Ethyl-10-Hydroxycamptothecin(SN-38)

CAS号

86639-52-3

分子式

C22H20N2O5

分子量

392.405

精确质量

392.137

PSA

101.65

LOGP

2.3476

编号系统

UNII

0H43101T0J

物化性质

外观与性状

淡黄色固体

密度

1.51 g/cm3

沸点

810.3ºC at 760 mmHg

熔点

217 °C

闪点

443.8ºC

折射率

21.5 ° (C=0.2, THF)

储存条件

-20ºC

安全信息

RTECS号

UQ0491000

海关编码

2942000000

生产方法及用途

用途

抗肿瘤药盐酸伊立替（CPT－
11）的关键中间体。

合成路线

共找到8条合成路线 >

伊立替康

4-哌啶基哌啶

4-哌啶基哌啶

7-乙基-10-羟基喜树碱

7-乙基-10-羟基喜树碱

海关数据

共找到1个国家海关数据 >

国家/地区名称	海关编码	更新时间	操作
中国	2942000000	2019-03	查看

上游原料

共找到73个上游原料 >

4-iodo-2-methoxy-6-trimethylsilanyl-3-pyridinecarboxaldehyde

4-iodo-2-methoxy-6-trimethylsilanyl-3-pyridinecarboxaldehyde

1-溴-2-戊炔

3-((benzyloxy)methyl)-6-chloro-4-(2-ethyl-1,3-dioxolan-2-yl)-2-methoxypyridine

3-((benzyloxy)methyl)-6-chloro-4-(2-ethyl-1,3-dioxolan-2-yl)-2-methoxypyridine

(S)-4-ethyl-4-hydroxy-6-iodo-8-methoxy-1,4-dihydro-pyrano[3,4-c]pyridin-3-one

(S)-4-ethyl-4-hydroxy-6-iodo-8-methoxy-1,4-dihydro-pyrano[3,4-c]pyridin-3-one

6-Chloro-4-(2-ethyl-[1,3]dioxolan-2-yl)-2-methoxy-pyridine-3-carbaldehyde

6-Chloro-4-(2-ethyl-[1,3]dioxolan-2-yl)-2-methoxy-pyridine-3-carbaldehyde

伊立替康

下游产品

共找到4个下游商品 >

(4S)-4,11-二乙基-3,4,12,14-四氢-4-羟基-3,14-二氧代-1H-吡喃并[3',4':6,7]吲哚嗪并[1,2-b]喹啉-9-基-beta-D-吡喃葡糖苷酸

(4S)-4,11-二乙基-3,4,12,14-四氢-4-羟基-3,14-二氧代-1H-吡喃并[3',4':6,7]吲哚嗪并[1,2-b]喹啉-9-基-beta-D-吡喃葡糖苷酸

伊立替康

盐酸伊立替康

盐酸伊立替康

SN-38三-O-乙酰基-beta-D-葡萄糖醛酸甲酯

SN-38三-O-乙酰基-beta-D-葡萄糖醛酸甲酯

上游原料

4-iodo-2-methoxy-6-trimethylsilanyl-3-pyridinecarboxaldehyde 1-溴-2-戊炔 3-((benzyloxy)methyl)-6-chloro-4-(2-ethyl-1,3-dioxolan-2-yl)-2-methoxypyridine (S)-4-ethyl-4-hydroxy-6-iodo-8-methoxy-1,4-dihydro-pyrano[3,4-c]pyridin-3-one 6-Chloro-4-(2-ethyl-[1,3]dioxolan-2-yl)-2-methoxy-pyridine-3-carbaldehyde 伊立替康 4-ethyl-8-methoxy-6-(trimethylsilyl)-1H-pyrano[3,4-c]pyridine 4-乙基-7,8-二氢-4-羟基-1H-吡喃并[3,4-f]吲嗪-3,6,10(4H)-三酮 1-(2-amino-5-methoxyphenyl)propan-1-one 喜树碱 2-methoxy-6-(trimethylsilyl)nicotinaldehyde 盐酸伊立替康丙醛 (+/-)-4-ethyl-4-hydroxy-8-methoxy-6-(trimethylsilyl)-1,4-dihydro-3H-pyrano[3,4-c]pyridin-3-one 7-乙基喜树碱 tert-butyl (4S)-4-ethyl-4,6-dihydroxy-3,10-dioxo-1,8-dihydropyrano[3,4-f]indolizine-7-carboxylate propyl (S)-4-ethyl-3,4-dihydro-4-hydroxy-8-methoxy-3-oxo-1H-pyrano[3,4-c]pyridine-6-carboxylate propyl (S)-4-ethyl-3,4,7,8-tetrahydro-4-hydroxy-3,8-dioxo-1H-pyrano[3,4-c] pyridine-6-carboxylate (3-(aminomethyl)-4-ethyl-6-methoxyquinolin-2-yl)methanol 2-((benzyloxy)methyl)-4-ethyl-6-methoxyquinoline-3-carbaldehyde 5-Benzyloxymethyl-4-((S)-1-formyl-1-hydroxy-propyl)-6-methoxy-pyridine-2-carboxylic acid propyl ester 7-ethyl-1,2,6,7-tetrahydro-20-(S)-camptothecin 6-chloro-4-(2-ethyl-1,3-dioxolan-2-yl)-2-methoxypyridine propyl 5-((benzyloxy)methyl)-4-(2-ethyl-1,3-dioxolan-2-yl)-6-methoxypicolinate 1-(2,6-Dichloro-pyridin-4-yl)-propan-1-one 10-acetoxy-20-acetyl-7-(2-trimethylsilylethynyl)camptothecin (S)-4-ethyl-4-hydroxy-6-iodo-3-oxo-1H-pyrano[3,4-c]-8-pyridone [6-chloro-4-(2-ethyl-1,3-dioxolan-2-yl)-2-methoxypyridin-3-yl]methanol 2'-amino-5'-hydroxypropiophenone 2-甲氧基-6-(三甲基硅烷基)吡啶柠嗪酸 (S)-(+)-4-ethyl-4-hydroxy-8-methoxy-6-(trimethylsilyl)-1,4-dihydro-3H-pyrano[3,4-c]pyridin-3-one propyl (4S)-4-ethyl-3,4-dihydroxy-8-methoxy-1,3-dihydropyrano[3,4-c]pyridine-6-carboxylate 7-ethyl-10-hydroxy-18,19-dehydrocamptothecin 4,11-diethyl-9-methoxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-14(12H)-one 2,6-二氯异烟酸 4-hydroxyphenyl isocyanide 羟基喜树碱 (S)-4,11-diethyl-4-hydroxy-9-methoxy-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinoline-3,14(4H,12H)-dione propyl 5-((benzyloxy)methyl)-4-(but-1-en-2-yl)-6-methoxypicolinate 7-Ethylcamptothecin 1-Oxide (S)-4-Ethyl-4-hydroxy-6-iodo-3-oxo-7-(2-pentynyl)-1H-pyrano[3,4-c]-8-pyridone propyl 4-(1,2-dihydroxybutan-2-yl)-6-methoxy-5-(phenylmethoxymethyl)pyridine-2-carboxylate (E)-3-ethoxy-1-(9-ethyl-3-hydroxy-7-methoxy-1H-pyrrolo[3,4-b]quinolin-2(3H)-yl)prop-2-en-1-one 7-乙基-10-羟基喜树碱中间体

下游产品

(4S)-4,11-二乙基-3,4,12,14-四氢-4-羟基-3,14-二氧代-1H-吡喃并[3',4':6,7]吲哚嗪并[1,2-b]喹啉-9-基-beta-D-吡喃葡糖苷酸伊立替康盐酸伊立替康 SN-38三-O-乙酰基-beta-D-葡萄糖醛酸甲酯