化合物简介
7,8-Dihydroxyflavone (7,8-DHF) is a naturally-occurring flavone found in Godmania aesculifolia, Tridax procumbens, and primula tree leaves. It has been found to act as a potent and selective small-molecule agonist of the TrkB receptor (Kd ≈ 320 nM), the main signaling receptor of brain-derived neurotrophic factor (BDNF). 7,8-DHF is both orally-bioavailable and able to penetrate the blood-brain-barrier.
基本信息
中文名称
7,8-二羟基黄酮
英文名称
7,8-DIHYDROXYFLAVONE
中文别名
英文别名
7,8-dihydroxy-2-phenylchromen-4-one、7,8-Dihydroxy-2-phenyl-4H-chromen-4-one、7,8-Dihydroxyflavone、7,8-Dihydroxyflavone Hydrate
CAS号
38183-03-8
分子式
C15H10O4
分子量
254.237
精确质量
254.058
PSA
70.67
LOGP
2.8712
编号系统
MDL号
MFCD00006836
物化性质
密度
1.443g/cm3
沸点
494.4ºC at 760 mmHg
熔点
243-246°C
闪点
193.5ºC
折射率
1.698
安全信息
RTECS号
DJ3004000
安全说明
S24/25
海关编码
2914400090
信号词
Warning
危险性描述
H302
危险标志
GHS07
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