马来酰亚胺

马来酰亚胺

CAS号:541-59-3
英文名:maleimide
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化合物简介
Maleimide is a chemical compound with the formula H2C2(CO)2NH (see diagram). This unsaturated imide is an important building block in organic synthesis. The name is a contraction of maleic acid and imide, the -C(O)NHC(O)- functional group. Maleimides also describes a class of derivatives of the parent maleimide where the NH group is replaced with alkyl or aryl groups such as a methyl or phenyl, respectively. The substituent can also be a polymer such as polyethylene glycol. Human hemoglobin chemically modified with maleimide-polyethylene glycol is a blood substitute called MP4.
基本信息
编号系统
物化性质
安全信息
生产方法及用途
生产方法
1.由吡咯与重铬酸钾反应而得。将1177g重铬酸钾溶于1200ml水及712ml浓硫酸中,加热至35℃,将54g吡咯在搅拌下慢慢加入,反反温度不超过50℃。加毕,在40-50℃保温反应至无吡咯气味时为止。冷却,用玻璃棉去反应生成的少量焦油,滤渣用热水洗涤。过滤、洗液用乙醚提取,提取液经无水硫酸钠干燥后,蒸发回收乙醚,得粗品结晶。用真空升华可得7g纯白结晶成品。
2. 烟草:FC,18, FC,40。
用途
用于有机合成、制药、化学分析等。
下游产品
3-phenylpyrrolidine-2,5-dione 1-乙烯基-1H-吡咯-2,5-二酮 1-but-3-enylpyrrole-2,5-dione 1-壬基-2,5-吡咯二酮 富马酸 3-(2,5-dioxopyrrolidin-3-yl)pyrrolidine-2,5-dione N-甲氧基羰基顺丁烯二酰亚胺 3-phenylpyrrole-2,5-dione 4-phenylbenzo[f]isoindole-1,3-dione 2,5-二氧代吡咯-1-甲酸乙酯 叔丁基 (2-(2,5-二氧代-2,5-二氢-1H-吡咯-1-基)乙基)氨基甲酸酯 2-吡咯烷酮 1-(羟甲基)-1H-吡咯-2,5-二酮 N-(2-氨基乙基)马来酰亚胺 N-环己基马来酰亚胺 3-(1H-indol-3-yl)pyrrolidine-2,5-dione N-苄基马来酰亚胺 顺式-5-苄基四氢吡咯并[3,4-c]吡咯-1,3(2H,3aH)-二酮 1-苯乙基吡咯-2,5-二酮 2,3-二溴马来酰亚胺 3-草氨酸钠 米丁度胺 3-[4-(trifluoromethyl)phenyl]pyrrole-2,5-dione 3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione 吡哆醇盐酸盐 二甲胺 3-benzylpyrrolidine-2,5-dione 2,3-萘二甲酰亚胺 1-(3-苯基丙基)-1H-吡咯-2,5-二酮 2,5-dimethyl-tetrahydro-cyclobuta[1,2-c,3,4-c']dipyrrole-1,3,4,6-tetraone 3-(4-methylphenyl)furan-2,5-dione 马来酰胺酸 2,5-二氢-2,5-二氧代-1H-吡咯-1-乙酸甲酯 丁二酰亚胺 1-triethylstannylpyrrole-2,5-dione 1-((4-甲氧基苯基)甲基)-1H-吡咯-2,5-二酮 3-methylazetidine-2,4-dione 5-(4-羟基苯基)海因 3-anilino-1-triethylstannylpyrrolidine-2,5-dione N-异丙基马来酰亚胺 N-甲基丁二酰胺 N-烯丙基马来酰亚胺 N-苯基马来酰亚胺 3-phenylselanylpyrrolidine-2,5-dione 4,7-dimethylisoindole-1,3-dione 3,4-di(4-methylphenyl)furan-2,5-dione 4-氧代-4-(环己基氨基)-2-丁烯酸